The role of IL-6 and its soluble receptor in chronic lung disease of prematurity

Powell, Wendy ORCID: https://orcid.org/0000-0002-4670-1406 2011. The role of IL-6 and its soluble receptor in chronic lung disease of prematurity. PhD Thesis, Cardiff University.

PDF - Accepted Post-Print Version Download (21MB)

Abstract

IL-6 trans-signalling was investigated in transformed airway epithelial cells (A549 and BEAS2B cells) and primary small airway epithelial cells (SAEC) in vitro. The cells expressed gp130 but not IL-6R. MCP-1 in response to IL-6 trans-signalling was variable and generally weak. Furthermore, IL-8 release was not downregulated by IL-6 trans-signalling. Instead, an increase in MCP-1 and IL-8 release was observed in response to a combined stimulation of IL-6 trans-signalling and IL-1[Special characters omitted]. This suggests that the pro-resolution paradigm of IL-6 trans-signalling may not be the case in airway epithelial cells.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Date of First Compliant Deposit:	30 March 2016
Last Modified:	25 Oct 2022 08:50
URI:	https://orca.cardiff.ac.uk/id/eprint/55501

Actions (repository staff only)

Edit Item