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Insulin-like growth factors and physical performance in old age: The Boyd Orr and Caerphilly studies [Abstract]

Birnie, K., Ben-Shlomo, Y., Ebrahim, Shehla, Gallacher, John Edward, Bayer, Antony James, Gunnell, D., Holly, J. M. and Martin, R. M. 2010. Insulin-like growth factors and physical performance in old age: The Boyd Orr and Caerphilly studies [Abstract]. Gerontologist 50 (S1) , p. 500. 10.1093/geront/gnq115

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Aims: The insulin-like growth factor (IGF) system regulates growth and IGF-I increases muscle mass, strength and body composition. Height and leg-length are markers for circulating IGF-I in pre-pubertal children; trunk length may be a marker for factors influencing pubertal growth. We assessed associations of the IGF system and height with physical performance in old age. Methods: Physical performance was measured with the get-up and go timed walk and flamingo balance test at 63-86 years. We examined cross-sectional associations in the UK Boyd Orr cohort (n=405) and prospective associations in the Caerphilly prospective study (CaPS) (n=730) from stored samples (average 17 years earlier). Results: In CaPs, a standard deviation (SD) increase in IGF-I was associated with a 2% faster walking time (95% confidence interval -4% to -1%; P=0.009) and 11% lower odds of poor balance (odds ratio 0.89; 0.78 to 1.02; P=0.10). There were no associations with IGFII or IGFBP-3. Cross-sectional effects of IGF-I on walking time were weaker in Boyd Orr (1% faster; -4% to 1%; P=0.39). Cross-sectional trunk-length was a better predictor of walking time than leg length (Boyd Orr 5% faster per SD increase; -8% to -2%: CaPS 2% faster per SD increase; -3% to 0%), but this was not seen for childhood trunk length or in the prospective CaPS data. Conclusion: These results are consistent with IGF-I in young to middle adulthood being more important in establishing peak physical performance, and reductions in

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Additional Information: Conference item - presented at The Gerontological Society of America 63rd Annual Scientific Meeting; November 19–23, 2010; New Orleans, LA
Publisher: Gerontological Society of America
ISSN: 0016-9013
Last Modified: 04 Jun 2017 04:00

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