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Clinical differences between bipolar and unipolar depression

Forty, Elizabeth, Smith, D., Jones, L., Jones, Ian Richard, Caesar, S., Cooper, C., Fraser, Christine, Gordon-Smith, K., Hyde, S., Farmer, A., McGuffin, P. and Craddock, Nicholas John 2008. Clinical differences between bipolar and unipolar depression. The British Journal of Psychiatry 192 (5) , pp. 388-389. 10.1192/bjp.bp.107.045294

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It is commonly – but wrongly – assumed that there are no important differences between the clinical presentations of major depressive disorder and bipolar depression. Here we compare clinical course variables and depressive symptom profiles in a large sample of individuals with major depressive disorder (n=593) and bipolar disorder (n=443). Clinical characteristics associated with a bipolar course included the presence of psychosis, diurnal mood variation and hypersomnia during depressive episodes, and a greater number of shorter depressive episodes. Such features should alert a clinician to a possible bipolar course. This is important because optimal management is not the same for bipolar and unipolar depression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Last Modified: 04 Jun 2017 03:53

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