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Human papillomavirus infection in Barrett's oesophagus in the UK: an infrequent event

Rai, N., Jenkins, G. J. S., McAdam, E., Hibbitts, Samantha Jayne, Fiander, Alison Nina and Powell, Ned George 2008. Human papillomavirus infection in Barrett's oesophagus in the UK: an infrequent event. Journal of Clinical Virology 43 (2) , pp. 250-252. 10.1016/j.jcv.2008.07.004

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Background Human papillomavirus (HPV) infection has been reported in squamous cell carcinomas of the oesophagus and has been recently described in Barrett's oesophagus, a premalignant condition which may give rise to oesophageal adenocarcinoma. Objectives To investigate HPV infection in Barrett's oesophagus in a UK population. Study design DNA was extracted from 73 Barrett's oesophagus biopsies and examined for the presence of DNA for 14 high risk (HR) and 6 low risk (LR) HPV types. Results HPV DNA was present in only 1 of 73 samples; genotyping indicated this was a high risk type 51 infection. Conclusions HPV infection appears unlikely to be a significant factor in the aetiology of Barrett's oesophagus in the UK.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords: HPV, Barrett's oesophagus, adenocarcinoma, squamous cell carcinoma
Publisher: Elsevier
ISSN: 1386-6532
Last Modified: 06 Feb 2020 22:45

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