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Genome wide association scan of co-morbid anxiety in major depressive disorder (MDD) [Abstract]

Schosser, A., Ng, M. Y., Butler, A. W., Uher, R., Cohen-Woods, S., Craddock, Nicholas John, Owen, Michael John, Aitchison, K. J., Breen, G., Craig, I., Farmer, A. E., Lewis, C. M. and McGuffin, P. 2010. Genome wide association scan of co-morbid anxiety in major depressive disorder (MDD) [Abstract]. International Journal of Psychiatry in Clinical Practice 14 (S1) , p. 37.

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Co-morbidity between depression and anxiety disorders is common. We investigated a broad phenotype of co-morbid anxiety in cases of major depressive disorder (MDD), and performed a genome-wide association (GWA) study in 1,621 subjects with DSM-IV and/or ICD-10 diagnosis of MDD, derived from three studies: DeCC (Depression Case Control, N � 648), GENDEP (Genome-based Therapeutic Drugs for Depression, N � 413), DeNt (Depression Network, N � 306), and a sample from Bonn and Lausanne (N � 254). Depression and anxiety were assessed using the SCAN interview, and a new variable was created named SU mmary An X iety (SUX) score, defi ned as the sum of scores for the following items: SCAN items 4.001 (general rating of anxiety), 4.002 (general rating of phobia), 4.023 (free-fl oating anxiety) and 4.024 (anxious foreboding with autonomic symptoms). All subjects therefore had a score between 0 and 8 for the worst and 2 nd worst episode, or current episode in GENDEP. SCAN item 1.002 (an anxiety screening item) was used to confi rm subjects with no anxiety. We performed genome-wide analysis of the quantitative SUX phenotype and a discrete trait (SUX � 0 vs SUX � 1), correcting for the Europe-wide ascertainment of cases. Five SNPs attained p-values of � 5 10^–6, suggesting evidence of association with anxiety: rs17221829 in the UBTFL2 gene with the quantitative SUX phenotype, rs9980603 and rs1040315 in DSCAM , rs10238623 in CREB5 and rs7867155 in NCRNA0092 with the discrete SUX phenotype. In conclusion, we found no SNP conferring a major contribution to co-morbid anxiety in MDD, analysed either as a continuous or discrete trait. Although this study highlighted several genes which may play a role in co-morbid anxiety, each will require replication in further studies to confi rm or refute their role.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Informa Healthcare
ISSN: 1365-1501
Related URLs:
Last Modified: 04 Jun 2017 03:15

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