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Adverse childhood experiences and postpartum depression in bipolar disorder

Perry, Amy, Gordon-Smith, Katherine, Di Florio, Arianna, Fraser, Christine, Craddock, Nick, Jones, Lisa and Jones, Ian 2020. Adverse childhood experiences and postpartum depression in bipolar disorder. Journal of Affective Disorders 263 , pp. 661-666. 10.1016/j.jad.2019.11.042

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Background Women are particularly vulnerable to recurrence of bipolar disorder (BD) following childbirth. Risk of postpartum psychosis (PP) is especially high, but postpartum depression (PPD) is also common. Adverse childhood experiences (ACEs) have not been associated with PP, but have been associated with PPD in non-bipolar samples. The relationship between ACEs and PPD within BD remains to be investigated. Here, we examined this association in a large, well-defined sample of women with BD. Methods Participants were 575 parous women with DSM-IV BD. Lifetime psychopathology, including perinatal, was assessed via semi-structured interview and case-notes. ACEs, assessed via self-report and case-notes, were compared between women with lifetime PPD (n=368) and those without a lifetime history of perinatal mood episodes (n=207). Results In univariate analysis exposure to 3 or more ACEs, and to childhood abuse specifically, was significantly associated with PPD (p=0.026 and 0.041 respectively), but this did not remain significant after adjusting for lifetime number of episodes of depression and parity. Post-hoc analysis revealed more frequent episodes of depression to be associated with both a history of 3 or more ACEs and of childhood abuse.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Elsevier
ISSN: 0165-0327
Date of First Compliant Deposit: 14 November 2019
Date of Acceptance: 9 November 2019
Last Modified: 07 Apr 2021 01:34

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