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Number of items: 25.

Flanagan, Dustin, Barker, Nick, Di Costanzo, Natasha S., Mason, Elizabeth A, Gurney, Austin, Meniel, Valerie S, Koushyar, Sarah, Austin, Chloe R, Pearson, Helen B, Boussioutas, Alex, Clevers, Hans, Phesse, Toby J and Vincan, Elizabeth 2019. Frizzled-7 is required for Wnt signaling in gastric tumours with and without Apc mutations. Cancer Research 79 (5) , pp. 970-981. 10.1158/0008-5472.CAN-18-2095
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Pearson, Helen, Li, Jason, Meniel, Valerie, Fennell, Christina, Waring, Paul, Montgomery, Karen, Rebello, Richard, Macpherson, Arthi, Koushyar, Sarah, Furic, Luc, Cullinane, Carleen, Clarkson, Richard, Smalley, Matthew, Simpson, Kaylene, Phesse, Toby, Shepherd, Peter, Humbert, Patrick, Sansom, Owen and Phillips, Wayne 2018. Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery 8 (6) , pp. 764-779. 10.1158/2159-8290.CD-17-0867
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Martin, Ana Carolina B.M., Fuzer, Angelina M., Becceneri, Amanda B., da Silva, James Almada, Tomasin, Rebeka, Denoyer, Delphine, Kim, Soo-Hyun, McIntyre, Katherine A., Pearson, Helen B., Yeo, Belinda, Nagpal, Aadya, Ling, Xiawei, Selistre-de-Araújo, Heloisa S., Vieira, Paulo Cézar, Cominetti, Marcia R. and Pouliot, Normand 2017. [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo. Oncotarget 8 (42) , pp. 72260-72271. 10.18632/oncotarget.20139
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Liu, David S., Duong, Cuong P., Haupt, Sue, Montgomery, Karen G., House, Colin M., Azar, Walid J., Pearson, Helen B., Fisher, Oliver M., Read, Matthew, Guerra, Glen R., Haupt, Ygal, Cullinane, Carleen, Wiman, Klas G., Abrahmsen, Lars, Phillips, Wayne A. and Clemons, Nicholas J. 2017. Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation. Nature Communications 8 , 14844. 10.1038/ncomms14844
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Rebello, Richard J, Kusnadi, Eric, Cameron, Donald P, Pearson, Helen, Lesmana, Analia, Devlin, Jennifer R., Drygin, Denis, Clark, Ashlee K., Porter, Laura, Pedersen, John, Sandhu, Shahneen, Risbridger, Gail P., Pearson, Richard B., Hannan, Ross D. and Furic, Luc 2016. The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer. Clinical Cancer Research 22 (22) , pp. 5539-5552. 10.1158/1078-0432.CCR-16-0124
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Denoyer, Delphine, Pearson, Helen B., Clatworthy, Sharnel A.S., Smith, Zoe M., Francis, Paul S., Llanos, Roxana M., Volitakis, Irene, Phillips, Wayne A., Meggyesy, Peter M., Masaldan, Shashank and Cater, Michael A. 2016. Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution. Oncotarget 7 (24) , pp. 37064-37080. 10.18632/oncotarget.9245
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Wölwer, Christina B., Pase, Luke B., Pearson, Helen B., Gödde, Nathan J., Lackovic, Kurt, Huang, David C. S., Russell, Sarah M. and Humbert, Patrick O. 2015. A chemical screening approach to identify novel key mediators of erythroid enucleation. PLoS ONE 10 (11) , e0142655. 10.1371/journal.pone.0142655
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Pearson, Helen B., McGlinn, Edwina, Phesse, Toby, Schlüter, Holger, Srikumar, Anuratha, Gödde, Nathan J., Woelwer, Christina B., Ryan, Andrew, Phillips, Wayne A., Ernst, Matthias, Kaur, Pritinder and Humbert, Patrick 2015. The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis. Molecular Cancer 14 (1) , 169. 10.1186/s12943-015-0440-z
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Sampurno, Shienny, Cross, Ryan, Pearson, Helen, Kaur, Pritinder, Malaterre, Jordane and Ramsay, Robert G. 2015. Myb via TGFβ is required for collagen type 1 production and skin integrity. Growth Factors 33 (2) , pp. 102-112. 10.3109/08977194.2015.1016222

Johnstone, C. N., Smith, Y. E., Cao, Y., Burrows, A. D., Cross, R. S. N., Ling, X., Redvers, R. P., Doherty, J. P., Eckhardt, B. L., Natoli, A. L., Restall, C. M., Lucas, E., Pearson, H. B., Deb, S., Britt, K. L., Rizzitelli, A., Li, J., Harmey, J. H., Pouliot, N. and Anderson, R. L. 2015. Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer. Disease Models and Mechanisms 8 (3) , pp. 237-251. 10.1242/dmm.017830
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Takizawa, Itsuhiro, Lawrence, Mitchell G., Balanathan, Preetika, Rebello, Richard, Pearson, Helen B., Garg, Elika, Pedersen, John, Pouliot, Normand, Nadon, Robert, Watt, Matthew J., Taylor, Renea A., Humbert, Patrick, Topisirovic, Ivan, Larsson, Ola, Risbridger, Gail P. and Furic, Luc 2015. Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity. Oncotarget 6 (2) , pp. 604-616. 10.18632/oncotarget.2820
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Elsum, I. A., Yates, L. L., Pearson, Helen B., Phesse, Toby, Long, F., O'Donoghue, R., Ernst, M., Cullinane, C. and Humbert, P. O. 2014. Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo. Oncogene 33 (48) , pp. 5523-5533. 10.1038/onc.2013.498

Gödde, Nathan J, Pearson, Helen B, Smith, Lorey K and Humbert, Patrick O 2014. Dissecting the role of polarity regulators in cancer through the use of mouse models. Experimental Cell Research 328 (2) , pp. 249-257. 10.1016/j.yexcr.2014.08.036

DiTommaso, Tia, Cottle, Denny L., Pearson, Helen B., Schlüter, Holger, Kaur, Pritinder, Humbert, Patrick O. and Smyth, Ian M. 2014. Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genetics 10 (10) , e1004706. 10.1371/journal.pgen.1004706
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Phesse, Toby, Buchert, M., Stuart, E., Flanagan, D. J., Faux, M., Afshar-Sterle, S., Walker, F., Zhang, H.-H., Nowell, C. J., Jorissen, R., Tan, C. W., Hirokawa, Y., Eissmann, M. F., Poh, A. R., Malaterre, J., Pearson, Helen B., Kirsch, D. G., Provero, P., Poli, V., Ramsay, R. G., Sieber, O., Burgess, A. W., Huszar, D., Vincan, E. and Ernst, M. 2014. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt- -catenin-mediated intestinal tumor growth and regeneration. Science Signaling 7 (345) , ra92. 10.1126/scisignal.2005411

Godde, Nathan J., Sheridan, Julie M., Smith, Lorey K., Pearson, Helen B., Britt, Kara L., Galea, Ryan C., Yates, Laura L., Visvader, Jane E. and Humbert, Patrick O. 2014. Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genetics 10 (5) , e1004323. 10.1371/journal.pgen.1004323
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Phesse, Toby, Myant, K. B., Cole, A. M., Ridgway, R. A., Pearson, Helen B., Muncan, V., van den Brink, G. R., Vousden, K. H., Sears, R., Vassilev, L . T ., Clarke, Alan Richard and Sansom, Owen J. 2014. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell Death and Differentiation 21 , pp. 956-966. 10.1038/cdd.2014.15
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Cater, Michael A., Pearson, Helen B., Wolyniec, Kamil, Klaver, Paul, Bilandzic, Maree, Paterson, Brett M., Bush, Ashley I., Humbert, Patrick O., La Fontaine, Sharon, Donnelly, Paul S. and Haupt, Ygal 2013. Increasing intracellular bioavailable copper selectively targets prostate cancer cells. ACS Chemical Biology 8 (7) , pp. 1621-1631. 10.1021/cb400198p

Pearson, Helen B. 2013. Modelling metastasis in vivo. Madame Curie Bioscience Database, Georgetown TX: Landes Bioscience,

Pouliot, Normand, Pearson, Helen and Burrows, Allan 2013. Investigating metastasis using in vitro platforms. Madame Curie Bioscience Database, Georgetown TX: Landes Bioscience,

Pearson, Helen B., Perez-Mancera, Pedro A., Dow, Lukas E., Ryan, Andrew, Tennstedt, Pierre, Bogani, Debora, Elsum, Imogen, Greenfield, Andy, Tuveson, David A., Simon, Ronald and Humbert, Patrick O. 2011. SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. The Journal of Clinical Investigation 121 (11) , pp. 4257-4267. 10.1172/JCI58509
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Shorning, Boris, Zabkiewicz, Joanna, McCarthy, Afshan, Pearson, Helen B., Winton, Douglas J., Sansom, Owen J., Ashworth, Alam and Clarke, Alan Richard 2009. Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE 4 (1) , e4264. 10.1371/journal.pone.0004264
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Pearson, Helen B., Phesse, Toby and Clarke, Alan Richard 2009. K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Research 69 (1) , pp. 94-101. 10.1158/0008-5472.CAN-08-2895

Pearson, Helen B., McCarthy, A., Collins, C. M., Ashworth, A. and Clarke, Alan Richard 2008. Lkb1 defiency causes prostate neoplasia in the mouse. Cancer Research 68 (7) , pp. 2223-2232. 10.1158/0008-5472.CAN-07-5169

Pearson, Helen B. 2008. Development and characterisation of novel mouse models of human prostate cancer. PhD Thesis, Cardiff University.
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This list was generated on Fri Feb 28 04:00:36 2020 GMT.


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