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Number of items: 34.

Young, Mark T. 2020. Journal club. Purinergic Signalling 10.1007/s11302-020-09720-3
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Grimes, Leanne, Griffiths, Julia, Pasqualetto, Gaia, Brancale, Andrea, Kemp, Paul J., Young, Mark T. and van der Goes van Naters, Wynand 2020. Drosophila taste neurons as an agonist-screening platform for P2X receptors. Scientific Reports 10 (1) , 8292. 10.1038/s41598-020-65169-9

Young, Mark T. 2020. Studying purinoceptor cell-surface expression by protein biotinylation. In: Pelegrin, P. ed. Purinergic Signaling: Methods and Protocols, Vol. 2041. Methods in Molecular Biology, Springer, pp. 137-146. (10.1007/978-1-4939-9717-6_9)

Giancotti, Gilda, Rigo, Ilaria, Pasqualetto, Gaia, Young, Mark T., Neyts, Johan, Rocha-Pereira, Joana, Brancale, Andrea, Ferla, Salvatore and Bassetto, Marcella 2019. A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase. Scientific Reports 9 (1) , 18413. 10.1038/s41598-019-54903-7

Pasqualetto, Gaia, Brancale, Andrea and Young, Mark T. 2018. The molecular determinants of small-molecule ligand binding at P2X receptors. Frontiers in Pharmacology 9 , 58. 10.3389/fphar.2018.00058

Palma, L., Scott, D. J., Harris, G., Din, Salah-Ud, Williams, Thomas, Roberts, Oliver, Young, Mark, Caballero, P. and Berry, Colin 2017. The Vip3Ag4 insecticidal protoxin from Bacillus thuringiensis adopts a tetrameric configuration that is maintained on proteolysis. Toxins 9 (5) , p. 165. 10.3390/toxins9050165

Grimes, Leanne and Young, Mark 2015. Purinergic P2X receptors: Structural and functional features depicted by X-ray and molecular modelling studies. Current Medicinal Chemistry 22 (7) , pp. 783-798. 10.2174/0929867321999141212131457

Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous A., Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles and Ambati, Jayakrishna 2014. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science 346 (6212) , pp. 1000-1003. 10.1126/science.1261754

Roberts, J. A., Allsopp, R. C., El Ajouz, S., Vial, C., Schmid, R., Young, Mark Thomas and Evans, R. J. 2012. Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel. Proceedings of the National Academy of Sciences 109 (12) , pp. 4663-4667. 10.1073/pnas.1201872109

Valente, Maria, Watterson, Summer J., Parker, Mark D., Ford, Robert C. and Young, Mark Thomas 2011. Expression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA. Biochimica et Biophysica Acta (BBA) - Biomembranes 1808 (12) , pp. 2859-2866. 10.1016/j.bbamem.2011.08.025

Fujii, Kotaro, Young, Mark Thomas and Harris, Kenneth David Maclean 2011. Exploiting powder X-ray diffraction for direct structure determination in structural biology: the P2X4 receptor trafficking motif YEQGL. Journal of Structural Biology 174 (3) , pp. 461-467. 10.1016/j.jsb.2011.03.001

Wu, Fiona, Saleem, Moin A., Kampik, Nicola B., Satchwell, Timothy J., Williamson, Rosalind C., Blattner, Simone M., Ni, Lan, Toth, Tibor, White, Graham, Young, Mark Thomas, Parker, Mark D., Alper, Seth L., Wagner, Carsten A. and Toye, Ashley M. 2010. Anion exchanger 1 interacts with nephrin in podocytes. Journal of the American Society of Nephrology 21 (9) , pp. 1456-1467. 10.1681/ASN.2009090921

Young, Mark Thomas 2010. P2X receptors: dawn of the post-structure era. Trends in Biochemical Sciences 35 (2) , pp. 83-90. 10.1016/j.tibs.2009.09.006

Cao, Lishuang, Broomhead, Helen, Young, Mark Thomas and North, R. Alan 2009. Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification. Journal of Neuroscience 29 (45) , pp. 14257-14264. 10.1523/JNEUROSCI.4403-09.2009

Young, Mark Thomas, Fisher, J., Fountain, S. J., Ford, R. C., North, R. and Khakh, B. S. 2008. Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy. Journal of Biological Chemistry 283 (38) , pp. 26241-26251. 10.1074/jbc.M804458200

Fountain, S. J., Cao, L., Young, Mark Thomas and North, R. 2008. Permeation properties of a P2X receptor in the green algae Ostreococcus tauri. Journal of Biological Chemistry 283 (22) , pp. 15122-15126. 10.1074/jbc.M801512200

Young, Mark Thomas, Zhang, Yi-Hong, Cao, Lishuang, Broomhead, Helen and Jiang, Lin-Hua 2008. Role of the domain encompassing Arg304–Ile328 in rat P2X2 receptor conformation revealed by alterations in complex glycosylation at Asn298. Biochemical Journal 416 (1) , pp. 137-143. 10.1042/BJ20081182

Cao, Lishuang, Young, Mark Thomas, Broomhead, Helen E., Fountain, Samuel J. and North, R. Alan 2007. Thr(339)-to-serine substitution in rat P2X(2) receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys(308). Journal of Neuroscience 27 (47) , pp. 12916-12923. 10.1523/JNEUROSCI.4036-07.2007

Barth, K., Weinhold, K., Guenther, A., Young, Mark Thomas, Schnittler, H. and Kasper, M. 2007. Caveolin-1 influences P2X(7) receptor expression and localization in mouse lung alveolar epithelial cells. Febs Journal 274 (12) , pp. 3021-3033. 10.1111/j.1742-4658.2007.05830.x

Fountain, Samuel J., Parkinson, Katie, Young, Mark Thomas, Cao, Lishuang, Thompson, Christopher R. L. and North, R. Alan 2007. An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum. Nature 448 (7150) , pp. 200-203. 10.1038/nature05926

Parker, Mark D., Young, Mark Thomas, Daly, Christopher M., Meech, Robert W., Boron, Walter F. and Tanner, Michael J. A. 2007. A conductive pathway generated from fragments of the human red cell anion exchanger AE1. The Journal of Physiology 581 (1) , pp. 33-50. 10.1113/jphysiol.2007.128389

Lopez-Castejon, Gloria, Young, Mark Thomas, Meseguer, Jose, Surprenant, Annmarie and Mulero, Victoriano 2007. Characterization of ATP-gated P2X(7) receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta. Molecular Immunology 44 (6) , pp. 1286-1299. 10.1016/j.molimm.2006.05.015

Young, Mark Thomas, Pelegrin, Pablo and Surprenant, Annmarie 2007. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Molecular Pharmacology 71 (1) , pp. 92-100. 10.1124/mol.106.030163

Young, Mark Thomas, Pelegrin, P. and Surprenant, A. 2006. Identification of Thr(283) as a key determinant of P2X(7) receptor function. British Journal of Pharmacology 149 (3) , pp. 261-268. 10.1038/sj.bjp.0706880

Sim, Joan A., Chaumont, Severine, Jo, Jihoon, Ulmann, Lauriane, Young, Mark Thomas, Cho, Kwangwook, Buell, Gary, North, R. Alan and Rassendren, Francois 2006. Altered hippocampal synaptic potentiation in P2X(4) knock-out mice. Journal of Neuroscience 26 (35) , pp. 9006-9009. 10.1523/JNEUROSCI.2370-06.2006

Mackenzie, A. B., Young, Mark Thomas, Adinolfi, E. and Surprenant, A. 2005. Pseudoapoptosis induced by brief activation of ATP-gated P2X7 receptors. Journal of Biological Chemistry 280 (40) , pp. 33968-33976. 10.1074/jbc.M502705200

Toye, A. M., Ghosh, S., Young, Mark Thomas, Jones, G. K., Sessions, R. B., Ramauge, M., Leclerc, P., Basu, J., Delaunay, J and Tanner, M. J. A. 2005. Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia. Blood 105 (10) , pp. 4088-4095. 10.1182/blood-2004-05-1895

Sim, J. A., Young, Mark Thomas, Sung, H. Y., North, R. A. and Surprenant, A. 2004. Reanalysis of P2X(7) receptor expression in rodent brain. Journal of Neuroscience 24 (28) , pp. 6307-6314. 10.1523/JNEUROSCI.1469-04.2004

Adinolfi, E., Kim, M., Young, Mark Thomas, Di Virgilio, F. and Surprenant, A. 2003. Tyrosine phosphorylation of HSP90 within the P2X(7) receptor complex negatively regulates P2X(7) receptors. Journal of Biological Chemistry 278 (39) , pp. 37344-37351. 10.1074/jbc.M301508200

Young, Mark and Tanner, M. J. A. 2003. Distinct regions of human glycophorin A enhance human red cell anion exchanger (Band 3; AE1) transport function and surface trafficking. Journal of Biological Chemistry 278 (35) , pp. 32954-32961. 10.1074/jbc.M302527200

Kanki, T., Young, Mark Thomas, Sakaguchi, M., Hamasaki, N. and Tanner, M. J. A. 2003. The N-terminal region of the transmembrane domain of human erythrocyte band 3. Residues critical for membrane insertion and transport activity. Journal of Biological Chemistry 278 (8) , pp. 5564-5573. 10.1074/jbc.M211662200

Bruce, L. J., Wrong, O., Toye, A. M., Young, Mark Thomas, Ogle, G., Ismail, Z., Sinha, A. K., McMaster, P., Hwaihwanje, I., Nash, G. B., Hart, S., Lavu, E., Palmer, R., Othman, A., Unwin, R. J. and Tanner, M. J. A. 2000. Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells. Biochemical Journal 350 (1) , pp. 41-51.

Young, Mark Thomas, Beckmann, R., Toye, A. M. and Tanner, M. J. A. 2000. Red-cell glycophorin A-band 3 interactions associated with the movement of band 3 to the cell surface. Biochemical Journal 350 , pp. 53-60. 10.1042/0264-6021:3500053

Dempsey, C. E., Sessions, R. B., Halsall, A., Takei, J., Gibbs, N and Young, Mark Thomas 1998. Helical structure and dynamics in membrane polypeptides. Biochemical Society Transactions 26 (3) , pp. 444-450. 10.1042/bst0260444

This list was generated on Sun Sep 27 06:08:57 2020 BST.