ORCA
Online Research @ Cardiff

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Browse by Current Cardiff authors

Number of items: 22.

McCann, Henry, Johnson, Charlotte, Errington, Rachel, Davies, D. Mark, Dunlop, Elaine and Tee, Andrew 2018. Energy stress-mediated cytotoxicity in tuberous sclerosis complex 2-deficient cells with nelfinavir and mefloquine treatment. Cancers 10 (10) , -. 10.3390/cancers10100375

Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, David Mark and Tee, Andrew R. 2018. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene 37 , pp. 5913-5925. 10.1038/s41388-018-0381-2

Yeung, V., Webber, J. P., Dunlop, E. A., Morgan, H., Hutton, J., Gurney, M., Jones, E., Falcon-Perez, J., Tabi, Z., Errington, R. and Clayton, A. 2018. Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma. Nanoscale 10 (18) , pp. 8547-8559. 10.1039/C8NR02417K

Carroll, Bernadette and Dunlop, Elaine A. 2017. The lysosome: a crucial hub for AMPK and mTORC1 signalling. Biochemical Journal 474 (9) , pp. 1453-1466. 10.1042/BCJ20160780

Dunlop, Elaine A, Johnson, Charlotte, Wiltshire, Marie, Errington, Rachel Jane and Tee, Andrew 2017. Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively. Oncotarget 10.18632/oncotarget.16232

Dodd, Kayleigh M. and Dunlop, Elaine A. 2016. Tuberous sclerosis—A model for tumour growth. Seminars in Cell and Developmental Biology 52 , pp. 3-11. 10.1016/j.semcdb.2016.01.025

Carroll, Bernadette, Maetzel, Dorothea, Maddocks, Oliver D. K., Otten, Gisela, Ratcliff, Matthew, Smith, Graham R., Dunlop, Elaine A., Passos, João F., Davies, Owen R., Jaenisch, Rudolf, Tee, Andrew, Sarkar, Sovan and Korolchuk, Viktor I. 2016. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. eLife 5 , e11058. 10.7554/eLife.11058

Dunlop, Elaine and Tee, Andrew 2014. mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Seminars in Cell and Developmental Biology 36 , pp. 121-129. 10.1016/j.semcdb.2014.08.006

Yan, Ming, Gingras, Marie-Claude, Dunlop, Elaine, Nouët, Yann, Dupuy, Fanny, Jalali, Zahra, Possik, Elite, Coull, Barry J., Kharitidi, Dmitri, Dydensborg, Anders Bondo, Faubert, Brandon, Kamps, Miriam, Sabourin, Sylvie, Preston, Rachael S., Davies, David, Roughead, Taren, Chotard, Laëtitia, van Steensel, Maurice A.M., Jones, Russell, Tee, Andrew and Pause, Arnim 2014. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. The Journal of Clinical Investigation 124 (6) , pp. 2640-2650. 10.1172/JCI71749

Dunlop, Elaine, Seifan, Sara, Claessens, Tijs, Behrends, Christian, Kamps, Miriam A.F., Rozycka, Ewelina, Kemp, Alain J., Nookala, Ravi K., Blenis, John, Coull, Barry J., Murray, James T., van Steensel, Maurice A.M., Wilkinson, Simon and Tee, Andrew 2014. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 10 (10) , pp. 1749-1760. 10.4161/auto.29640

Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew, Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A., Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa and Walker, Cheryl Lyn 2013. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature Cell Biology 15 (10) , pp. 1186-1195. 10.1038/ncb2822

Thomas, Laura, Richards, Mark, Mort, Matthew Edwin, Dunlop, Elaine A., Cooper, David Neil and Upadhyaya, Meena 2012. Assessment of the potential pathogenicity of missense mutations identified in the GTPase-activating protein (GAP)-related domain of the neurofibromatosis type-1 (NF1) gene. Human Mutation 33 (12) , pp. 1687-1696. 10.1002/humu.22162

Dunlop, Elaine A., Hunt, David K., Acosta-Jaquez, Hugo A., Fingar, Diane C. and Tee, Andrew 2011. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 7 (7) , pp. 737-747. 10.4161/auto.7.7.15491

Dunlop, Elaine A., Dodd, Kayleigh M., Land, Stephen C, Davies, Peter A., Martins, Nicole, Stuart, Helen, McKee, Shane, Kingswood, Chris, Saggar, Anand, Corderio, Isabel, Medeira, Ana Maria Duarte, Kingston, Helen, Sampson, Julian Roy, Davies, David Mark and Tee, Andrew 2011. Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence. European Journal of Human Genetics 19 (7) , pp. 789-795. 10.1038/ejhg.2011.38

Preston, Rachael S., Philp, A., Claessens, T., Gijezen, L., Dydensborg, A. B., Dunlop, Elaine A., Harper, Katy T., Brinkhuizen, T., Menko, F. H., Davies, David Mark, Land, S. C., Pause, A., Baar, K., van Steensel, M. A. M. and Tee, Andrew 2011. Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene 30 (10) , pp. 1159-1173. 10.1038/onc.2010.497

Soliman, G. A., Acosta-Jaquez, H. A., Dunlop, Elaine A., Ekim, B., Maj, N. E., Tee, Andrew and Fingar, D. C. 2010. mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action. Journal of Biological Chemistry 285 (11) , pp. 7866-7879. 10.1074/jbc.M109.096222

Shi, Zhanzhong., Hodges, Vivien M., Dunlop, Elaine A., Percy, Melanie J., Maxwell, Alexander P., El-Tanani, Mohamed. and Lappin, Terry R. J. 2010. Erythropoietin-induced activation of the JAK2/STAT5, PI3K/Akt, and Ras/ERK pathways promotes malignant cell behavior in a modified breast cancer cell line. Molecular Cancer Research 8 (4) , pp. 615-626. 10.1158/1541-7786.MCR-09-0264

Dunlop, Elaine A., Dodd, Kayleigh M., Seymour, Lyndsey A. and Tee, Andrew 2009. Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Cellular Signalling 21 (7) , pp. 1073-1084. 10.1016/j.cellsig.2009.02.024

Dunlop, Elaine A. and Tee, Andrew 2009. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cellular Signalling 21 (6) , pp. 827-835. 10.1016/j.cellsig.2009.01.012

Dunlop, Elaine A., Maxwell, Alexander P. and Lappin, Terence R. J. 2007. Impaired downregulation following erythropoietin receptor activation in non-small cell lung carcinoma. Stem Cells 25 (2) , pp. 380-384. 10.1634/stemcells.2006-0452

Brown, W. Mark, Maxwell, Perry, Graham, Alastair N. j., Yakkundi, Anita, Dunlop, Elaine A., Shi, Zhanzhong, Johnston, Patrick G. and Lappin, Terence R. J. 2006. Erythropoietin receptor expression in non-Small cell lung carcinoma: a question of antibody specificity. Stem Cells 25 (3) , pp. 718-722. 10.1634/stemcells.2006-0687

Dunlop, Elaine A., Percy, M. J., Boland, M. P., Maxwell, A. P. and Lappin, T. R. 2006. Induction of signalling in non-erythroid cells by pharmacological levels of erythropoietin. Neurodegenerative Diseases 3 (1-2) , pp. 94-100. 10.1159/000092099

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