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Zhang, Lei, Evans, Anna, von Ruhland, Chris, Draman, Mohd Shazli, Edkins, Sarah, Vincent, Amy E., Berlinguer-Palmini, Rolando, Rees, D. Aled, Haridas, Anjana S, Morris, Dan, Tee, Andrew R., Ludgate, Marian, Turnbull, Doug M., Karpe, Fredrik and Dayan, Colin M.
2020.
Distinctive features of orbital adipose tissue (OAT) in Graves' orbitopathy.
International Journal of Molecular Sciences
21
(23)
, 9145.
10.3390/ijms21239145
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McEneaney, Lauren J. and Tee, Andrew R. 2019. Finding a cure for tuberous sclerosis complex: from genetics through to targeted drug therapies. Advances in Genetics 103 , pp. 91-118. 10.1016/bs.adgen.2018.11.003 |
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Bruning, Ulrike, Morales-Rodriguez, Francisco, Kalucka, Joanna, Goveia, Jermaine, Taverna, Federico, Queiroz, Karla C.S., Dubois, Charlotte, Cantelmo, Anna Rita, Chen, Rongyuan, Loroch, Stefan, Timmerman, Evy, Caixeta, Vanessa, Bloch, Katarzyna, Conradi, Lena-Christin, Treps, Lucas, Staes, An, Gevaert, Kris, Tee, Andrew, Dewerchin, Mieke, Semenkovich, Clay F., Impens, Francis, Schilling, Birgit, Verdin, Eric, Swinnen, Johannes V., Meier, Jordan L., Kulkarni, Rhushikesh A., Sickmann, Albert, Ghesquière, Bart, Schoonjans, Luc, Li, Xuri, Mazzone, Massimiliano and Carmeliet, Peter 2018. Impairment of angiogenesis by fatty acid synthase inhibition Involves mTOR malonylation. Cell Metabolism 28 (6) , pp. 866-880. 10.1016/j.cmet.2018.07.019 |
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Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, D. Mark and Tee, Andrew R. 2018. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene 37 , pp. 5913-5925. 10.1038/s41388-018-0381-2 |
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McCann, Henry, Johnson, Charlotte, Errington, Rachel, Davies, D. Mark, Dunlop, Elaine and Tee, Andrew 2018. Energy stress-mediated cytotoxicity in tuberous sclerosis complex 2-deficient cells with nelfinavir and mefloquine treatment. Cancers 10 (10) , -. 10.3390/cancers10100375 |
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Murray, James and Tee, Andrew 2018. Mechanistic Target of Rapamycin (mTOR) in the cancer setting. Cancers 10 (6) , p. 168. 10.3390/cancers10060168 |
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Tee, Andrew 2018. The target of rapamycin and mechanisms of cell growth. International Journal of Molecular Sciences 19 (3) , pp. 880-892. 10.3390/ijms19030880 |
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Johnson, Charlotte E. and Tee, Andrew R. 2017. Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance. Essays in Biochemistry 61 (6) , pp. 699-710. 10.1042/EBC20170056 |
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Tee, Andrew 2016. The benefits of exploiting rare genetic disorders to better understand human health and disease. Seminars in Cell & Developmental Biology 52 , pp. 1-2. 10.1016/j.semcdb.2016.03.007 |
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Carroll, Bernadette, Maetzel, Dorothea, Maddocks, Oliver D. K., Otten, Gisela, Ratcliff, Matthew, Smith, Graham R., Dunlop, Elaine A., Passos, João F., Davies, Owen R., Jaenisch, Rudolf, Tee, Andrew, Sarkar, Sovan and Korolchuk, Viktor I. 2016. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. eLife 5 , -. 10.7554/eLife.11058 |
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Rad, Ellie and Tee, Andrew 2016. Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer. Seminars in Cell & Developmental Biology 52 , pp. 39-46. 10.1016/j.semcdb.2016.02.007 |
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Tee, Andrew, Sampson, Julian Roy, Pal, Deb K. and Bateman, Joseph M. 2016. The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex. Seminars in Cell and Developmental Biology 52 , pp. 12-20. 10.1016/j.semcdb.2016.01.040 |
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Upadhyaya, Meena, Winston, Jincy, Radcliffe, E., Mort, Matthew, Dodd, Kayleigh, Tee, Andrew, McDyer, F., Moore, S., Cooper, David Neil and Thomas, L. 2015. Correlation of copy number changes and gene expression in neurofibromatosis1-associated malignant peripheral nerve sheath tumours [Abstract]. Pediatric Blood and Cancer 62 (S4) , S152-S152. 10.1002/pbc.25715 |
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Zhang, Lei, Ji, Q. H. J., Ruge, Fiona, Lane, C., Morris, D., Tee, Andrew, Dayan, Colin Mark and Ludgate, Marian Elizabeth 2015. Reversal of pathological features of Graves' orbitopathy by activation of forkhead transcription factors, FOXOs. Journal of Clinical Endocrinology & Metabolism 101 (1) , pp. 114-122. 10.1210/jc.2015-2932 |
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Rad, Ellie, Dodd, Kayleigh M., Thomas, Laura E., Upadhyaya, Meena and Tee, Andrew 2015. STAT3 and HIF1 signaling drives oncogenic cellular phenotypes in malignant peripheral nerve sheath tumors. Molecular Cancer Research 13 (7) , p. 1149. 10.1158/1541-7786.MCR-14-0182 |
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Dodd, K. M., Yang, J., Shen, M. H., Sampson, J. R. and Tee, A. R. 2015. mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3. Oncogene 34 (17) , pp. 2239-2250. 10.1038/onc.2014.164 |
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Thomas, Laura E., Winston, Jincy, Rad, Ellie, Mort, Matthew, Dodd, Kayleigh M., Tee, Andrew, McDyer, Fionnuala, Moore, Stephen, Cooper, David Neil and Upadhyaya, Meena
2015.
Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours.
Human Genomics
9
(1)
, 3.
10.1186/s40246-015-0025-3
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Dunlop, Elaine and Tee, Andrew 2014. mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Seminars in Cell and Developmental Biology 36 , pp. 121-129. 10.1016/j.semcdb.2014.08.006 |
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Tee, Andrew 2014. Fundamental for life: mTOR orchestrates developing biological systems. Seminars in Cell & Developmental Biology 36 , pp. 66-67. 10.1016/j.semcdb.2014.10.001 |
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Johnson, Charlotte, Hunt, David K., Wiltshire, Marie, Herbert, Terry P., Sampson, Julian Roy, Errington, Rachel J., Davies, David Mark and Tee, Andrew 2014. Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine. Molecular Oncology 9 (3) , pp. 675-688. 10.1016/j.molonc.2014.11.005 |
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Zhang, Lei, Grennan-Jones, Fiona, Draman, M.S., Lane, C., Morris, D., Dayan, Colin, Tee, Andrew and Ludgate, Marian Elizabeth 2014. Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy. Journal of Clinical Endocrinology & Metabolism 99 (7) , E1183-E1190. 10.1210/jc.2013-4182 |
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Yan, Ming, Gingras, Marie-Claude, Dunlop, Elaine A., Nouët, Yann, Dupuy, Fanny, Jalali, Zahra, Possik, Elite, Coull, Barry J., Kharitidi, Dmitri, Dydensborg, Anders Bondo, Faubert, Brandon, Kamps, Miriam, Sabourin, Sylvie, Preston, Rachael S., Davies, David Mark, Roughead, Taren, Chotard, Laëtitia, van Steensel, Maurice A.M., Jones, Russell, Tee, Andrew R. and Pause, Arnim 2014. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. Journal of Clinical Investigation 124 (6) , pp. 2640-2650. 10.1172/JCI71749 |
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Dunlop, Elaine, Seifan, Sara, Claessens, Tijs, Behrends, Christian, Kamps, Miriam A.F., Rozycka, Ewelina, Kemp, Alain J., Nookala, Ravi K., Blenis, John, Coull, Barry J., Murray, James T., van Steensel, Maurice A.M., Wilkinson, Simon and Tee, Andrew 2014. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 10 (10) , pp. 1749-1760. 10.4161/auto.29640 |
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Luijten, Monique N. H., Basten, Sander G., Claessens, Tijs, Vernooij, Marigje, Scott, Claire L., Janssen, Renske, Easton, Jennifer A., Kamps, Miriam A. F., Vreeburg, Maaike, Broers, Jos L. V., van Geel, Michel, Menko, Fred H., Harbottle, Richard P., Nookala, Ravi K., Tee, Andrew, Land, Stephen C., Giles, Rachel H., Coull, Barry J. and van Steensel, Maurice A. M. 2013. Birt–Hogg–Dubé syndrome is a novel ciliopathy. Human Molecular Genetics 22 (21) , pp. 4383-4397. 10.1093/hmg/ddt288 |
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Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew, Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A., Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa and Walker, Cheryl Lyn 2013. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature Cell Biology 15 (10) , pp. 1186-1195. 10.1038/ncb2822 |
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Dhingra, R, Gang, H, Wang, Y, Biala, A, Aviv, Y, Margulets, V, Tee, Andrew and Kirshenbaum, L 2013. Bidirectional regulation of nuclear factor- B and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular myocytes. Circulation: Heart Failure 6 (2) , pp. 335-343. 10.1161/CIRCHEARTFAILURE.112.000061 |
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Tripathi, Durga N., Chowdhury, Rajdeep, Trudel, Laura J., Tee, Andrew, Slack, Rebecca S., Walker, Cheryl Lyn and Wogan, Gerald N. 2013. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proceedings of the National Academy of Sciences of the United States of America 110 (32) , E2950-E2957. 10.1073/pnas.1307736110 |
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Tee, Andrew and Pause, Arnim 2012. Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin. Familial Cancer 12 (3) , pp. 367-372. 10.1007/s10689-012-9576-9 |
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Dunlop, Elaine A., Hunt, David K., Acosta-Jaquez, Hugo A., Fingar, Diane C. and Tee, Andrew 2011. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 7 (7) , pp. 737-747. 10.4161/auto.7.7.15491 |
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Dunlop, Elaine A., Dodd, Kayleigh M., Land, Stephen C, Davies, Peter A., Martins, Nicole, Stuart, Helen, McKee, Shane, Kingswood, Chris, Saggar, Anand, Corderio, Isabel, Medeira, Ana Maria Duarte, Kingston, Helen, Sampson, Julian Roy, Davies, David Mark and Tee, Andrew 2011. Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence. European Journal of Human Genetics 19 (7) , pp. 789-795. 10.1038/ejhg.2011.38 |
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Preston, Rachael S., Philp, A., Claessens, T., Gijezen, L., Dydensborg, A. B., Dunlop, Elaine A., Harper, Katy T., Brinkhuizen, T., Menko, F. H., Davies, David Mark, Land, S. C., Pause, A., Baar, K., van Steensel, M. A. M. and Tee, Andrew 2011. Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene 30 (10) , pp. 1159-1173. 10.1038/onc.2010.497 |
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Scott, C. L., Walker, D. J., Cwiklinski, E., Tait, C., Tee, Andrew and Land, S. C. 2010. Control of HIF-1α and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock. AJP: Lung Cellular and Molecular Physiology 299 (4) , L455-L471. 10.1152/ajplung.00348.2009 |
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Soliman, G. A., Acosta-Jaquez, H. A., Dunlop, Elaine A., Ekim, B., Maj, N. E., Tee, Andrew and Fingar, D. C. 2010. mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action. Journal of Biological Chemistry 285 (11) , pp. 7866-7879. 10.1074/jbc.M109.096222 |
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Dunlop, Elaine A., Dodd, Kayleigh M., Seymour, Lyndsey A. and Tee, Andrew 2009. Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Cellular Signalling 21 (7) , pp. 1073-1084. 10.1016/j.cellsig.2009.02.024 |
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Dunlop, Elaine A. and Tee, Andrew 2009. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cellular Signalling 21 (6) , pp. 827-835. 10.1016/j.cellsig.2009.01.012 |
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Tee, Andrew, Sampson, Julian Roy and Cheadle, Jeremy Peter 2009. Tuberous sclerosis complex. In: Schwab, Manfred ed. Encyclopedia of Cancer. 2nd ed, Springer, |
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Baird, Fiona E., Bett, Kevin J., MacLean, Catherine, Tee, Andrew, Hundal, Harinder. S. and Taylor, Peter M. 2009. Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes. American Journal of Physiology. Endocrinology and Metabolism 297 (3) , E822-E829. 10.1152/ajpendo.00330.2009 |
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Tee, Andrew, Manning, Brendan D., Roux, Philippe P., Cantley, Lewis C. and Blenis, John 2003. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current Biology 13 (15) , pp. 1259-1268. 10.1016/S0960-9822(03)00506-2 |
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Tee, Andrew, Fingar, Diane C., Manning, Brendan D., Kwiatkowski, David J., Cantley, Lewis C. and Blenis, John 2002. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences 99 (21) , pp. 13571-13576. 10.1073/pnas.202476899 |
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Manning, Brendan D., Tee, Andrew, Logsdon, M. Nicole, Blenis, John and Cantley, Lewis C. 2002. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Molecular Cell 10 (1) , pp. 151-162. 10.1016/S1097-2765(02)00568-3 |
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Tee, Andrew and Proud, C. G. 2002. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Molecular and Cellular Biology 22 (6) , pp. 1674-1683. 10.1128/MCB.22.6.1674-1683.2002 |
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