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Number of items: 42.

McEneaney, Lauren J. and Tee, Andrew R. 2019. Finding a cure for tuberous sclerosis complex: from genetics through to targeted drug therapies. Advances in Genetics 103 , pp. 91-118. 10.1016/bs.adgen.2018.11.003
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Bruning, Ulrike, Morales-Rodriguez, Francisco, Kalucka, Joanna, Goveia, Jermaine, Taverna, Federico, Queiroz, Karla C.S., Dubois, Charlotte, Cantelmo, Anna Rita, Chen, Rongyuan, Loroch, Stefan, Timmerman, Evy, Caixeta, Vanessa, Bloch, Katarzyna, Conradi, Lena-Christin, Treps, Lucas, Staes, An, Gevaert, Kris, Tee, Andrew, Dewerchin, Mieke, Semenkovich, Clay F., Impens, Francis, Schilling, Birgit, Verdin, Eric, Swinnen, Johannes V., Meier, Jordan L., Kulkarni, Rhushikesh A., Sickmann, Albert, Ghesquière, Bart, Schoonjans, Luc, Li, Xuri, Mazzone, Massimiliano and Carmeliet, Peter 2018. Impairment of angiogenesis by fatty acid synthase inhibition Involves mTOR malonylation. Cell Metabolism 28 (6) , pp. 866-880. 10.1016/j.cmet.2018.07.019

McCann, Henry, Johnson, Charlotte, Errington, Rachel, Davies, D. Mark, Dunlop, Elaine and Tee, Andrew 2018. Energy stress-mediated cytotoxicity in tuberous sclerosis complex 2-deficient cells with nelfinavir and mefloquine treatment. Cancers 10 (10) , -. 10.3390/cancers10100375

Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, David Mark and Tee, Andrew R. 2018. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene 37 , pp. 5913-5925. 10.1038/s41388-018-0381-2

Murray, James and Tee, Andrew 2018. Mechanistic Target of Rapamycin (mTOR) in the cancer setting. Cancers 10 (6) , p. 168. 10.3390/cancers10060168

Tee, Andrew 2018. The target of rapamycin and mechanisms of cell growth. International Journal of Molecular Sciences 19 (3) , pp. 880-892. 10.3390/ijms19030880

Rad, Ellie, Murray, James and Tee, Andrew 2018. Oncogenic signalling through mechanistic Target Of Rapamycin (mTOR): a driver of metabolic transformation and cancer progression. Cancers 10 (1) 10.3390/cancers10010005

Johnson, Charlotte E. and Tee, Andrew R. 2017. Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance. Essays in Biochemistry 61 (6) , pp. 699-710. 10.1042/EBC20170056

Dunlop, Elaine A, Johnson, Charlotte, Wiltshire, Marie, Errington, Rachel Jane and Tee, Andrew 2017. Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively. Oncotarget 10.18632/oncotarget.16232

Tee, Andrew 2016. The benefits of exploiting rare genetic disorders to better understand human health and disease. Seminars in Cell & Developmental Biology 52 , pp. 1-2. 10.1016/j.semcdb.2016.03.007

Carroll, Bernadette, Maetzel, Dorothea, Maddocks, Oliver D. K., Otten, Gisela, Ratcliff, Matthew, Smith, Graham R., Dunlop, Elaine A., Passos, João F., Davies, Owen R., Jaenisch, Rudolf, Tee, Andrew, Sarkar, Sovan and Korolchuk, Viktor I. 2016. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. eLife 5 , e11058. 10.7554/eLife.11058

Rad, Ellie and Tee, Andrew 2016. Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer. Seminars in Cell & Developmental Biology 52 , pp. 39-46. 10.1016/j.semcdb.2016.02.007

Tee, Andrew, Sampson, Julian Roy, Pal, Deb K. and Bateman, Joseph M. 2016. The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex. Seminars in Cell and Developmental Biology 52 , pp. 12-20. 10.1016/j.semcdb.2016.01.040

Upadhyaya, Meena, Winston, Jincy, Radcliffe, E., Mort, Matthew, Dodd, Kayleigh, Tee, Andrew, McDyer, F., Moore, S., Cooper, David Neil and Thomas, L. 2015. Correlation of copy number changes and gene expression in neurofibromatosis1-associated malignant peripheral nerve sheath tumours [Abstract]. Pediatric Blood and Cancer 62 (S4) , S152-S152. 10.1002/pbc.25715

Zhang, Lei, Ji, Q. H. J., Ruge, Fiona, Lane, C., Morris, D., Tee, Andrew, Dayan, Colin Mark and Ludgate, Marian Elizabeth 2015. Reversal of pathological features of Graves' orbitopathy by activation of forkhead transcription factors, FOXOs. Journal of Clinical Endocrinology & Metabolism 101 (1) , pp. 114-122. 10.1210/jc.2015-2932

Rad, Ellie, Dodd, Kayleigh M., Thomas, Laura E., Upadhyaya, Meena and Tee, Andrew 2015. STAT3 and HIF1 signaling drives oncogenic cellular phenotypes in malignant peripheral nerve sheath tumors. Molecular Cancer Research 13 (7) , p. 1149. 10.1158/1541-7786.MCR-14-0182

Dodd, Kayleigh, Yang, Jian, Shen, Ming, Sampson, Julian Roy and Tee, Andrew 2015. mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3. Oncogene 34 (17) , pp. 2239-2250. 10.1038/onc.2014.164

Thomas, Laura E., Winston, Jincy, Rad, Ellie, Mort, Matthew, Dodd, Kayleigh M., Tee, Andrew, McDyer, Fionnuala, Moore, Stephen, Cooper, David Neil and Upadhyaya, Meena 2015. Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours. Human Genomics 9 (1) , 3. 10.1186/s40246-015-0025-3

Dunlop, Elaine and Tee, Andrew 2014. mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Seminars in Cell and Developmental Biology 36 , pp. 121-129. 10.1016/j.semcdb.2014.08.006

Tee, Andrew 2014. Fundamental for life: mTOR orchestrates developing biological systems. Seminars in Cell & Developmental Biology 36 , pp. 66-67. 10.1016/j.semcdb.2014.10.001

Johnson, Charlotte, Hunt, David K., Wiltshire, Marie, Herbert, Terry P., Sampson, Julian Roy, Errington, Rachel J., Davies, David Mark and Tee, Andrew 2014. Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine. Molecular Oncology 9 (3) , pp. 675-688. 10.1016/j.molonc.2014.11.005

Zhang, Lei, Grennan-Jones, Fiona, Draman, M.S., Lane, C., Morris, D., Dayan, Colin, Tee, Andrew and Ludgate, Marian Elizabeth 2014. Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy. Journal of Clinical Endocrinology & Metabolism 99 (7) , E1183-E1190. 10.1210/jc.2013-4182

Yan, Ming, Gingras, Marie-Claude, Dunlop, Elaine, Nouët, Yann, Dupuy, Fanny, Jalali, Zahra, Possik, Elite, Coull, Barry J., Kharitidi, Dmitri, Dydensborg, Anders Bondo, Faubert, Brandon, Kamps, Miriam, Sabourin, Sylvie, Preston, Rachael S., Davies, David, Roughead, Taren, Chotard, Laëtitia, van Steensel, Maurice A.M., Jones, Russell, Tee, Andrew and Pause, Arnim 2014. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. The Journal of Clinical Investigation 124 (6) , pp. 2640-2650. 10.1172/JCI71749

Dunlop, Elaine, Seifan, Sara, Claessens, Tijs, Behrends, Christian, Kamps, Miriam A.F., Rozycka, Ewelina, Kemp, Alain J., Nookala, Ravi K., Blenis, John, Coull, Barry J., Murray, James T., van Steensel, Maurice A.M., Wilkinson, Simon and Tee, Andrew 2014. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 10 (10) , pp. 1749-1760. 10.4161/auto.29640

Luijten, Monique N. H., Basten, Sander G., Claessens, Tijs, Vernooij, Marigje, Scott, Claire L., Janssen, Renske, Easton, Jennifer A., Kamps, Miriam A. F., Vreeburg, Maaike, Broers, Jos L. V., van Geel, Michel, Menko, Fred H., Harbottle, Richard P., Nookala, Ravi K., Tee, Andrew, Land, Stephen C., Giles, Rachel H., Coull, Barry J. and van Steensel, Maurice A. M. 2013. Birt–Hogg–Dubé syndrome is a novel ciliopathy. Human Molecular Genetics 22 (21) , pp. 4383-4397. 10.1093/hmg/ddt288

Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew, Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A., Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa and Walker, Cheryl Lyn 2013. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature Cell Biology 15 (10) , pp. 1186-1195. 10.1038/ncb2822

Dhingra, R, Gang, H, Wang, Y, Biala, A, Aviv, Y, Margulets, V, Tee, Andrew and Kirshenbaum, L 2013. Bidirectional regulation of nuclear factor- B and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular myocytes. Circulation: Heart Failure 6 (2) , pp. 335-343. 10.1161/CIRCHEARTFAILURE.112.000061

Tripathi, Durga N., Chowdhury, Rajdeep, Trudel, Laura J., Tee, Andrew, Slack, Rebecca S., Walker, Cheryl Lyn and Wogan, Gerald N. 2013. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proceedings of the National Academy of Sciences of the United States of America 110 (32) , E2950-E2957. 10.1073/pnas.1307736110

Tee, Andrew and Pause, Arnim 2012. Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin. Familial Cancer 12 (3) , pp. 367-372. 10.1007/s10689-012-9576-9

Dunlop, Elaine A., Hunt, David K., Acosta-Jaquez, Hugo A., Fingar, Diane C. and Tee, Andrew 2011. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 7 (7) , pp. 737-747. 10.4161/auto.7.7.15491

Dunlop, Elaine A., Dodd, Kayleigh M., Land, Stephen C, Davies, Peter A., Martins, Nicole, Stuart, Helen, McKee, Shane, Kingswood, Chris, Saggar, Anand, Corderio, Isabel, Medeira, Ana Maria Duarte, Kingston, Helen, Sampson, Julian Roy, Davies, David Mark and Tee, Andrew 2011. Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence. European Journal of Human Genetics 19 (7) , pp. 789-795. 10.1038/ejhg.2011.38

Preston, Rachael S., Philp, A., Claessens, T., Gijezen, L., Dydensborg, A. B., Dunlop, Elaine A., Harper, Katy T., Brinkhuizen, T., Menko, F. H., Davies, David Mark, Land, S. C., Pause, A., Baar, K., van Steensel, M. A. M. and Tee, Andrew 2011. Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene 30 (10) , pp. 1159-1173. 10.1038/onc.2010.497

Scott, C. L., Walker, D. J., Cwiklinski, E., Tait, C., Tee, Andrew and Land, S. C. 2010. Control of HIF-1α and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock. AJP: Lung Cellular and Molecular Physiology 299 (4) , L455-L471. 10.1152/ajplung.00348.2009

Soliman, G. A., Acosta-Jaquez, H. A., Dunlop, Elaine A., Ekim, B., Maj, N. E., Tee, Andrew and Fingar, D. C. 2010. mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action. Journal of Biological Chemistry 285 (11) , pp. 7866-7879. 10.1074/jbc.M109.096222

Dunlop, Elaine A., Dodd, Kayleigh M., Seymour, Lyndsey A. and Tee, Andrew 2009. Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Cellular Signalling 21 (7) , pp. 1073-1084. 10.1016/j.cellsig.2009.02.024

Dunlop, Elaine A. and Tee, Andrew 2009. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cellular Signalling 21 (6) , pp. 827-835. 10.1016/j.cellsig.2009.01.012

Tee, Andrew, Sampson, Julian Roy and Cheadle, Jeremy Peter 2009. Tuberous sclerosis complex. In: Schwab, Manfred ed. Encyclopedia of Cancer. 2nd ed, Springer,

Baird, Fiona E., Bett, Kevin J., MacLean, Catherine, Tee, Andrew, Hundal, Harinder. S. and Taylor, Peter M. 2009. Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes. American Journal of Physiology. Endocrinology and Metabolism 297 (3) , E822-E829. 10.1152/ajpendo.00330.2009

Tee, Andrew, Manning, Brendan D., Roux, Philippe P., Cantley, Lewis C. and Blenis, John 2003. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current Biology 13 (15) , pp. 1259-1268. 10.1016/S0960-9822(03)00506-2

Tee, Andrew, Fingar, Diane C., Manning, Brendan D., Kwiatkowski, David J., Cantley, Lewis C. and Blenis, John 2002. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences 99 (21) , pp. 13571-13576. 10.1073/pnas.202476899

Manning, Brendan D., Tee, Andrew, Logsdon, M. Nicole, Blenis, John and Cantley, Lewis C. 2002. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Molecular Cell 10 (1) , pp. 151-162. 10.1016/S1097-2765(02)00568-3

Tee, Andrew and Proud, C. G. 2002. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Molecular and Cellular Biology 22 (6) , pp. 1674-1683. 10.1128/MCB.22.6.1674-1683.2002

This list was generated on Thu Oct 17 05:13:01 2019 BST.

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