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Number of items: 47.

Forbester, Jessica L., Clement, Mathew, Wellington, Dannielle, Yeung, Amy, Dimonte, Sandra, Marsden, Morgan, Chapman, Lucy, Coomber, Eve L., Tolley, Charlotte, Lees, Emily, Hale, Christine, Clare, Simon, Udalova, Irina, Dong, Tao, Dougan, Gordon and Humphreys, Ian R. 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94 (9) , e00121-20. 10.1128/JVI.00121-20

O'Donnell, Valerie B, Thomas, David, Stanton, Richard, Maillard, Jean-Yves, Murphy, Robert C, Jones, Simon A, Humphreys, Ian, Wakelam, Michael J O, Fegan, Christopher, Wise, Matt P, Bosch, Albert and Sattar, Syed A. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 10.1093/function/zqaa002

Lucchesi, Davide, Coleby, Rachel, Pontarini, Elena, Prediletto, Edoardo, Rivellese, Felice, Hill, David G., Derrac Soria, Alicia, Jones, Simon, Humphreys, Ian, Sutcliffe, Nurhan, Tappuni, Anwar R., Pitzalis, Costantino, Jones, Gareth W. and Bombardieri, Michele 2020. Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome. Arthritis and Rheumatology 10.1002/art.41289
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Shelkovnikova, Tatyana, An, Haiyan, Skelt, Lucy, Tregoning, John S, Humphreys, Ian R and Buchman, Vladimir L 2019. Antiviral immune response as a trigger of FUS proteinopathy in amyotrophic lateral sclerosis. Cell Reports 29 (13) , 4496-4508.e4. 10.1016/j.celrep.2019.11.094

Singhania, Akul, Graham, Christine M., Gabryšová, Leona, Moreira-Teixeira, Lúcia, Stavropoulos, Evangelos, Pitt, Jonathan M., Chakravarty, Probir, Warnatsch, Annika, Branchett, William J., Conejero, Laura, Lin, Jing-Wen, Davidson, Sophia, Wilson, Mark S., Bancroft, Gregory, Langhorne, Jean, Frickel, Eva, Sesay, Abdul K., Priestnall, Simon L., Herbert, Eleanor, Ioannou, Marianna, Wang, Qian, Humphreys, Ian R., Dodd, Jonathan, Openshaw, Peter J. M., Mayer-Barber, Katrin D., Jankovic, Dragana, Sher, Alan, Lloyd, Clare M., Baldwin, Nicole, Chaussabel, Damien, Papayannopoulos, Venizelos, Wack, Andreas, Banchereau, Jacques F., Pascual, Virginia M. and O'Garra, Anne 2019. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications 10 , 2887. 10.1038/s41467-019-10601-6

Thompson, Aiysha, Davies, Luke C., Liao, Chia-Te, da Fonseca, Diogo M., Griffiths, James S., Andrews, Robert, Jones, Adam V., Clement, Mathew, Brown, Gordon D., Humphreys, Ian R., Taylor, Philip R. and Orr, Selinda J. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15 (6) , e1007850. 10.1371/journal.ppat.1007850

Smith, S. E., Busse, D. C., Binter, S., Weston, S., Diaz Soria, C., Laksono, B. M., Clare, S., Van Nieuwkoop, S., Van den Hoogen, B. G., Clement, M., Marsden, M., Humphreys, I. R., Marsh, M., de Swart, R. L., Wash, R. S., Tregoning, J. S. and Kellam, P. 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane. Journal of Virology 93 (6) , e02003-18. 10.1128/JVI.02003-18

McLaren, James, Clement, Mathew, Marsden, Morgan, Miners, Kelly L., Llewellyn-Lacey, Sian, Grant, Emma J., Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A., Orr, Selinda J., Stanton, Richard J., Ladell, Kristin, Price, David A. and Humphreys, Ian R. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3) , pp. 943-955. 10.4049/jimmunol.1701757

Clement, Mathew and Humphreys, Ian R. 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10 , 78. 10.3389/fimmu.2019.00078

Gimeno Brias, Silvia, Marsden, Morgan, Forbester, Jessica, Clement, Mathew, Brandt, Cordelia, Harcourt, Katherine, Kane, Leanne, Chapman, Lucy, Clare, Simon and Humphreys, Ian R. 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13 (5) , e0197596. 10.1371/journal.pone.0197596

Humphreys, Ian R. and Sebastian, Sarah 2018. Novel viral vectors in infectious diseases. Immunology 153 (1) , pp. 1-9. 10.1111/imm.12829

Rai, Taranjit Singh, Glass, Mandy, Cole, John J., Rather, Mohammad I., Marsden, Morgan, Neilson, Matthew, Brock, Claire, Humphreys, Ian R., Everett, Roger D. and Adams, Peter D. 2017. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research 45 (20) , pp. 11673-11683. 10.1093/nar/gkx771

Sowerby, John M., Thomas, David C., Clare, Simon, Espéli, Marion, Guerrero, Jose A., Hoenderdos, Kim, Harcourt, Katherine, Marsden, Morgan, Abdul-Karim, Juneid, Clement, Mathew, Antrobus, Robin, Umrania, Yagnesh, Barton, Philippa R., Flint, Shaun M., Juss, Jatinder K., Condliffe, Alison M., Lyons, Paul A., Humphreys, Ian R., Chilvers, Edwin R., Ouwehand, Willem H., Dougan, Gordon and Smith, Kenneth G. C. 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127 (9) , pp. 3521-3526. 10.1172/JCI91684

Stacey, Maria A., Clare, Simon, Clement, Mathew, Marsden, Morgan, Abdul-Karim, Juneid, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Fielding, Ceri A., Smith, Sarah E., Wash, Rachael S., Brias, Silvia Gimeno, Stack, Gabrielle, Notley, George, Cambridge, Emma L., Isherwood, Christopher, Speak, Anneliese O., Johnson, Zoe, Ferlin, Walter, Jones, Simon A., Kellam, Paul and Humphreys, Ian R. 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127 (4) , pp. 1463-1474. 10.1172/JCI84889

Clement, Mathew, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon, Godkin, Andrew, Ghazal, Peter, Jones, Gareth W. and Humphreys, Ian 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) , e1006050. 10.1371/journal.ppat.1006050

Perks, William V., Singh, Ravinder K., Jones, Gareth W., Twohig, Jason P., Williams, Anwen S., Humphreys, Ian R., Taylor, Philip R., Jones, Simon A. and Wang, Eddie C. Y. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186 (11) , pp. 2813-2823. 10.1016/j.ajpath.2016.07.021

Liao, Chia-Te, Rosas, Marcela, Davies, Luke C., Giles, Peter J., Tyrrell, Victoria J., O'Donnell, Valerie B., Topley, Nicholas, Humphreys, Ian R., Fraser, Donald J., Jones, Simon A. and Taylor, Philip R. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9) , pp. 2222-2232. 10.1002/eji.201646528

Patin, Emmanuel, Jones, Adam V., Thompson, Aiysha, Clement, Mathew, Liao, Chia-Te, Griffiths, James S., Wallace, Leah, Bryant, Clare E., Lang, Roland, Rosenstiel, Philip, Humphreys, Ian R., Taylor, Philip Russel, Jones, Gareth Wyn and Orr, Selinda Jane 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197 (1) , pp. 208-221. 10.4049/jimmunol.1501204

Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A., Redwood, Alec J. and Humphreys, Ian R. 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 , 00211. 10.3389/fimmu.2016.00211

Mohammed, Rebar N., Watson, H. Angharad, Vigar, Miriam, Ohme, Julia, Thomson, Amanda, Humphreys, Ian R. and Ager, Ann 2016. L-selectin is essential for delivery of activated CD8+ T cells to virus-infected organs for protective immunity. Cell Reports 14 (4) , pp. 760-771. 10.1016/j.celrep.2015.12.090

Stack, Gabrielle, Jones, Emma, Marsden, Morgan, Stacey, Maria A., Snelgrove, Robert J., Lacaze, Paul, Jacques, Laura C., Cuff, Simone, Stanton, Richard J., Gallimore, Awen M., Hussell, Tracy, Wilkinson, Gavin W. G., Ghazal, Peter, Taylor, Philip R. and Humphreys, Ian R. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11 (2) , e1004641. 10.1371/journal.ppat.1004641

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul Nazeer, Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela, Taylor, Philip Russel, O'Neill, Luke A., Humphreys, Ian R., Williams, Anwen Sian and Jones, Simon Arnett 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) , 419. 10.1186/s13075-014-0419-y

Stacey, Maria A., Marsden, Morgan, Pham N, Tu Anh, Clare, Simon, Dolton, Garry, Stack, Gabrielle, Jones, Emma, Klenerman, Paul, Gallimore, Awen M., Taylor, Philip R., Snelgrove, Robert J., Lawley, Trevor D., Dougan, Gordon, Benedict, Chris A., Jones, Simon A., Wilkinson, Gavin W. G. and Humphreys, Ian R. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4) , pp. 471-483. 10.1016/j.chom.2014.03.003

Fielding, Ceri A., Jones, Gareth W., McLoughlin, Rachel M., McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen S., Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal S., Hams, Emily, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John D., Williams, Geraint T., Davies, Simon J., Humphreys, Ian R., O'Donnell, Valerie B., Taylor, Philip R., Jenkins, Brendan J., Topley, Nicholas and Jones, Simon A. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40 (1) , pp. 40-50. 10.1016/j.immuni.2013.10.022

Segrott, Jeremy, Rothwell, Heather Ann, Murphy, Simon, Morgan-Trimmer, Sarah, Scourfield, Jonathan Bryn, Holliday, Joanne, Thomas, Claire, Gillespie, David, Roberts, Zoe Elizabeth Sara, Foxcroft, David, Hood, Kerenza, Reed, Hayley, Humphreys, Ian R. and Moore, Laurence Anthony Russell 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference, Glasgow, Scotland,, 19-22 November 2014.

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Harvey, Ann, Moideen, Abdul Nazeer, Collins, Fraser, Bloom, Anja Constanze, Coll, R., Rosas, Marcela, Taylor, Philip Russel, O'Neill, L. A., Humphreys, Ian R., Williams, Anwen Sian and Jones, Simon Arnett 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3) , p. 267. 10.1016/j.cyto.2013.06.105

Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin Ingrid, McLaren, James Edward, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David, Ager, Ann, Wooldridge, Linda, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

Pembroke, Thomas, Rees, Ian W., Gallagher, Kathleen, Jones, Emma, Mizen, Paul Edward, Navruzov, Timur, Freedman, Andrew Robert, Fielding, Ceri Alan, Humphreys, Ian R., Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9) , pp. 2383-2394. 10.1002/eji.201142072

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Moideen, Abdul Nazeer, Rosas, Marcela, Taylor, Philip Russel, Humphreys, Ian R., Williams, Anwen Sian and Jones, Simon Arnett 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137 , pp. 43-44.

Twohig, Jason Peter, Marsden, Morgan, Cuff, Simone, Ferdinand, John R., Gallimore, Awen Myfanwy, Perks, William Victor, Al-Shamkhani, Aymen, Humphreys, Ian R. and Wang, Edward Chung Yern 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26 (8) , pp. 3575-3586. 10.1096/fj.11-200618

Stack, Gabrielle, Stacey, Maria A. and Humphreys, Ian R. 2012. Herpesvirus exploitation of host immune inhibitory pathways. Viruses 4 (12) , pp. 1182-1201. 10.3390/v4081182

Greenhill, Claire, Williams, Anwen Sian, Jones, Gareth Wyn, Nowell, Mari Ann, Moideen, Abdul Nazeer, Rosas, Marcela, Taylor, Philip Russel, Humphreys, Ian R. and Jones, Simon Arnett 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51 , p. 48. 10.1093/rheumatology/kes117

Greenhill, Claire J., Williams, Anwen Sian, Jones, Gareth Wyn, Nowell, Mari Ann, Rosas, Marcela, Taylor, Philip Russel, Humphreys, Ian R. and Jones, Simon Arnett 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135 (s1) , p. 158. 10.1111/j.1365-2567.2011.03534.x

Stacey, Maria A., Marsden, Morgan, Wang, Edward Chung Yern, Wilkinson, Gavin William Grahame and Humphreys, Ian R. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187 (6) , pp. 2944-2952. 10.4049/jimmunol.1101021

Humphreys, Ian R., Lee, Seung-Woo, Jones, Morgan, Loewendorf, Andrea, Gostick, Emma, Price, David A., Benedict, Chris A., Ware, Carl F. and Croft, Michael 2010. Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells. European Journal of Immunology 40 (10) , pp. 2762-2768. 10.1002/eji.200940256

Jones, Morgan, Ladell, Kristin Ingrid, Wynn, Katherine, Stacey, Maria A., Quigley, Maire F., Gostick, Emma, Price, David and Humphreys, Ian R. 2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6) , pp. 3583-3592. 10.4049/jimmunol.1001535

Humphreys, Ian R., Loewendorf, Andrea, De Trez, Carl, Schneider, Kirsten, Benedict, Chris A., Munks, Michael W., Ware, Carl F. and Croft, Michael 2007. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T cells: a CD4 dependent mechanism. Journal of Immunology 179 , pp. 2195-2202.

Humphreys, Ian R., De Trez, Carl, Kinkade, April, Benedict, Chris A., Croft, Michael and Ware, Carl F. 2007. Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands. Journal of Experimental Medicine 204 (5) , pp. 1217-25. 10.1084/jem.20062424

Cheung, T. C., Humphreys, Ian R., Potter, K. G., Norris, P. S., Shumway, H. M., Tran, B. R., Patterson, G., Jean-Jacques, R., Yoon, M., Spear, P. G., Murphy, K. M., Lurain, N. S., Benedict, C. A. and Ware, C. F. 2005. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proceedings of the National Academy of Sciences 102 (47) , pp. 13218-13223. 10.1073/pnas.0506172102

Stewart, G. R, Newton, S. M, Wilkinson, K. A, Humphreys, Ian, Murphy, H. N, Robertson, B. D, Wilkinson, R. J and Young, D. B 2005. The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Molecular Microbiology 55 (4) , pp. 1127-1137. 10.1111/j.1365-2958.2004.04450.x

Hale, C, Humphreys, Ian, Hussell, T, Bowe, F, Clare, S, Pickard, D, Preston, A, Del Giudice, G and Dougan, G 2004. Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines. Vaccine 22 (27-28) , pp. 3595-3602. 10.1016/j.vaccine.2004.03.039

Hussell, T, Snelgrove, R, Humphreys, Ian and Williams, A. E 2004. Co-stimulation: novel methods for preventing viral-induced lung inflammation. Trends in Molecular Medicine 10 (8) , pp. 379-386. 10.1016/j.molmed.2004.06.006

Humphreys, Ian R., Walzl, Gerhard, Hussell, Tracy and Hill, Sue 2003. A critical role for OX40 in T cell-mediated immunopathology during lung viral infection. Journal of Experimental Medicine 198 (8) , pp. 1237-42. 10.1084/jem.20030351

Humphreys, Ian, Edwards, L CARDIFF??, Walzl, G, Rae, A. J, Dougan, G, Hill, S and Hussell, T 2003. OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. Journal of Immunology 170 (12) , pp. 6125-6132. 10.4049/jimmunol.170.12.6125

Walzl, G, Humphreys, Ian, Marshall, B. G, Edwards, L CARDIFF??, Openshaw, P. J, Shaw, R. J and Hussell, T 2003. Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner. Infection and Immunity 71 (6) , pp. 3384-3391. 10.1128/IAI.71.6.3384-3391.2003

Dearman, R.J, Filby, A, Humphreys, Ian and Kimber, I 2002. Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides. Journal of Applied Toxicology 22 (5) , pp. 317-325. 10.1002/jat.865

Dearman, R.J, Warbrick, E.V, Humphreys, Ian and Kimber, I 2000. Characterization in mice of the immunological properties of five allergenic acid anhydrides. Journal of Applied Toxicology 20 (3) , pp. 221-230. 10.1002/(SICI)1099-1263(200005/06)20:3<221::AID-JAT651>3.0.CO;2-#

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