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Number of items: 102.

Dolton, Garry, Rius, Cristina, Wall, Aaron, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Bianchi, Valentina, Galloway, Sarah A.E., Hasan, MD Samiul, Morin, Theo, Caillaud, Marine, Thomas, Hannah L., Theaker, Sarah, Tan, Li Rong, Fuller, Anna, Topley, Katie, Legut, Mateusz, Attaf, Merriem, Hopkins, Jade R., Behiry, Enas, Zabkiewicz, Joanna ORCID: https://orcid.org/0000-0003-0951-3825, Alvares, Caroline ORCID: https://orcid.org/0000-0003-4391-9802, Lloyd, Angharad, Rogers, Amber, Henley, Peter, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330, Man, Stephen ORCID: https://orcid.org/0000-0001-9103-1686, Crowther, Michael D., Donia, Marco, Svane, Inge Marie, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Brown, Paul E., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186 (16) , pp. 3333-3349. 10.1016/j.cell.2023.06.020
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Bates, Emily A., Davies, James A. ORCID: https://orcid.org/0000-0003-3569-4500, Vánová, Jana, Nestic, Davor, Meniel, Valerie S., Koushyar, Sarah, Cunliffe, Tabitha G., Mundy, Rosie M., Moses, Elise, Uusi-Kerttula, Hanni K., Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Majhen, Dragomira, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Chester, John D. ORCID: https://orcid.org/0000-0002-7830-3840 and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761 2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10. Molecular Therapy - Oncolytics 25 , pp. 43-56. 10.1016/j.omto.2022.03.007
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Man, Stephen ORCID: https://orcid.org/0000-0001-9103-1686, Redman, James E. ORCID: https://orcid.org/0000-0001-5492-2869, Cross, Deborah L., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Can, Ilona, Davies, Bethan, Hashimdeen, Shaikh Shimaz, Reid, Reiss, Llewellyn-Lacey, Sian, Miners, Kelly L., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Lissina, Anya, Brown, Paul E., Wooldridge, Linda, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 2021. Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells. Journal of Immunology 207 (4) , pp. 1009-1017. 10.4049/jimmunol.2000756

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Knezevic, Lea, Dockree, Tamsin, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, van den Berg, Hugo A. and Wooldridge, Linda 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118 (29) , e2019639118. 10.1073/pnas.2019639118
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Lanz, Anna-Lisa, Masi, Giulia, Porciello, Nicla, Cohnen, André, Cipria, Deborah, Prakaash, Dheeraj, Bálint, Štefan, Raggiaschi, Roberto, Galgano, Donatella, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Lepore, Marco, Dushek, Omer, Dustin, Michael L., Sansom, Mark S.P., Kalli, Antreas C. and Acuto, Oreste 2021. Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation. Cell Reports 36 (2) , 109375. 10.1016/j.celrep.2021.109375
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Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Davies, James A. ORCID: https://orcid.org/0000-0003-3569-4500, Bates, Emily A., Moses, Elise, Mundy, Rosie M., Marlow, Gareth ORCID: https://orcid.org/0000-0002-7608-9086, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Bliss, Carly M., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761 2021. The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanism. Journal of Virology 95 (4) , e01849-20. 10.1128/JVI.01849-20
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MacLachlan, Bruce J., Mason, Georgina H., Greenshields Watson, Alexander, Triebel, Frederic, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2021. Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor. European Journal of Immunology 51 (2) , pp. 331-341. 10.1002/eji.202048753
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Hopkins, Jade R., Crean, Rory M., Catici, Dragana A. M., Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Arcus, Vickery L., Van der Kamp, Marc W., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Pudney, Christopher R. 2020. Peptide cargo tunes a network of correlated motions in human leukocyte antigens. FEBS Journal 287 (17) , pp. 3777-3793. 10.1111/febs.15278
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Bovay, Amandine, Zoete, Vincent, Rizkallah, Pierre J ORCID: https://orcid.org/0000-0002-9290-0369, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Delbreil, Philippe, Speiser, Daniel E, Cole, David K ORCID: https://orcid.org/0000-0003-0028-9396 and Fuertes Marraco, Silvia A 2020. Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b214-222 by combinatorial peptide library screening. Molecular Immunology 125 , pp. 43-50. 10.1016/j.molimm.2020.06.025
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Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L. ORCID: https://orcid.org/0000-0003-0889-964X, Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew J. ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew J. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) , 107885. 10.1016/j.celrep.2020.107885
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Saeed, Mesha, Schooten, Erik, van Brakel, Mandy, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, ten Hagen, Timo L. M. and Debets, Reno 2020. T Cells expressing a TCR-like antibody selected against the heteroclitic variant of a shared MAGE-A epitope do not recognise the cognate epitope. Cancers 12 (5) , 1255. 10.3390/cancers12051255
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Holland, Christopher J., Crean, Rory M., Pentier, Johanne M., de Wet, Ben, Lloyd, Angharad, Srikannathasan, Velupillai, Lissin, Nikolai, Lloyd, Katy A., Blicher, Thomas H., Conroy, Paul J., Hock, Miriam, Pengelly, Robert J., Spinner, Thomas E., Cameron, Brian, Potter, Elizabeth A., Jeyanthan, Anitha, Molloy, Peter E., Sami, Malkit, Aleksic, Milos, Liddy, Nathaniel, Robinson, Ross A., Harper, Stephen, Lepore, Marco, Pudney, Chris R., van der Kamp, Marc W., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Jakobsen, Bent K., Vuidepot, Annelise and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2020. Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA. Journal of Clinical Investigation 130 (5) , 2673–2688. 10.1172/JCI130562

Whalley, Thomas, Dolton, Garry, Brown, Paul E., Wall, Aaron, Wooldridge, Linda, van den Berg, Hugo, Fuller, Anna, Hopkins, Jade R., Crowther, Michael D., Attaf, Meriem, Knight, Robin R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11 , 296. 10.3389/fimmu.2020.00296
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Bagaev, Dmitry V, Vroomans, Renske M A, Samir, Jerome, Stervbo, Ulrik, Rius, Cristina, Dolton, Garry, Greenshields Watson, Alexander, Attaf, Meriem, Egorov, Evgeny S, Zvyagin, Ivan V, Babel, Nina, Cole, David K ORCID: https://orcid.org/0000-0003-0028-9396, Godkin, Andrew J ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Kesmir, Can, Chudakov, Dmitriy M, Luciani, Fabio and Shugay, Mikhail 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48 (D1) , D1057-D1062. 10.1093/nar/gkz874
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MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Elliott, Tim, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294 (52) , pp. 20246-20258. 10.1074/jbc.RA119.009437
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Madura, Florian, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49 (7) , pp. 1052-1066. 10.1002/eji.201948085
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Galloway, Sarah A. E., Dolton, Garry, Attaf, Meriem, Wall, Aaron, Fuller, Anna, Rius, Cristina, Bianchi, Valentina, Theaker, Sarah, Lloyd, Angharad, Caillaud, Marine E., Svane, Inge Marie, Donia, Marco, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10 , 319. 10.3389/fimmu.2019.00319
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Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Greenshields-Watson, Alexander, Coughlan, Lynda, Davies, James A. ORCID: https://orcid.org/0000-0003-3569-4500, Uusi-Kerttula, Hanni, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761 2019. Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions. Nature Communications 10 , 741. 10.1038/s41467-019-08599-y
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Alraies, Amr ORCID: https://orcid.org/0000-0003-1977-3487, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Rees, Jeremy, Glasse, Carl, Young, Nigel, Waddington, Rachel ORCID: https://orcid.org/0000-0001-5878-1434 and Sloan, Alastair ORCID: https://orcid.org/0000-0002-1791-0903 2019. Real-time binding kinetic analyses of the interaction of the dietary stain Orange II with dentin matrix. Journal of Dentistry 80 , pp. 80-88. 10.1016/j.jdent.2018.06.001
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Tungatt, Katie, Dolton, Garry, Morgan, Sophie B., Attaf, Meriem, Fuller, Anna, Whalley, Thomas, Hemmink, Johanneke D., Porter, Emily, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Montoya, Maria, Hammond, John A., Miles, John J., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Townsend, Alain, Bailey, Mick, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Charleston, Bryan, Tchilian, Elma and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14 (5) , e1007017. 10.1371/journal.ppat.1007017
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Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wells, Stephen and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9 , 674. 10.3389/fimmu.2018.00674
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Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Makinde, Julia, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gras, Stephanie, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Burrows, Scott R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512
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Bovay, Amandine, Zoete, Vincent, Dolton, Garry, Bulek, Anna M., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Fuller, Anna, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Michielin, Olivier, Speiser, Daniel E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Fuertes Marraco, Silvia A. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48 (2) , pp. 258-272. 10.1002/eji.201747082
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Maciocia, Paul M., Wawrzyniecka, Patrycja A., Philip, Brian, Ricciardelli, Ida, Akarca, Ayse U., Onuoha, Shimobi C., Legut, Mateusz, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gritti, Giuseppe, Somja, Joan, Piris, Miguel A., Peggs, Karl S., Linch, David C., Marafioti, Teresa and Pule, Martin A. 2017. Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies. Nature Medicine 23 , pp. 1416-1423. 10.1038/nm.4444
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J., Bulek, Anna M., Bridgeman, John S., Miles, John J., Schauenburg, Andrea J. A., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Evavold, Brian D., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8 , 1503. 10.3389/fimmu.2017.01503
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Jones, Nicholas, Cronin, James G., Dolton, Garry, Panetti, Silvia, Schauenburg, Andrea, Galloway, Sarah A. E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Thornton, Catherine A. and Francis, Nigel J. ORCID: https://orcid.org/0000-0002-4706-4795 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8 , 1516. 10.3389/fimmu.2017.01516
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Fuller, Anna, Wall, Aaron, Crowther, Michael D., Lloyd, Angharad, Zhurov, Alexei ORCID: https://orcid.org/0000-0002-5594-0740, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484 2017. Thermal stability of heterotrimeric pMHC proteins as determined by circular dichroism spectroscopy. Bio-protocol 7 (13) , -. 10.21769/BioProtoc.2366
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MacLachlan, Bruce J., Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea J., Bianchi, Valentina, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Fuller, Anna and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments (120) , e54991. 10.3791/54991
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, van den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna M., Dolton, Garry, Schauenburg, Andrea J., Wall, Aaron, Fuller, Anna, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Laugel, Bruno, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292 (3) , pp. 802-813. 10.1074/jbc.M116.741603
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Bulek, Anna M., Dolton, Garry, Schauenberg, Andrea J., Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Zhu, Cheng, Miles, John J., Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126 (6) , pp. 2191-2204. 10.1172/JCI85679
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Bianchi, Valentina, Bulek, Anna, Fuller, Anna, Lloyd, Angharad, Attaf, Meriem, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Dolton, Garry, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291 (17) , pp. 8951-8959. 10.1074/jbc.M115.707414
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Theaker, Sarah M., Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew R., Fuller, Anna, Miles, John James, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Dolton, Garry Michael 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430 , pp. 43-50. 10.1016/j.jim.2016.01.014
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Jones, Kimberley, Wockner, Leesa, Brennan, Rebekah M., Keane, Colm, Chattopadhyay, Pratip K., Roederer, Mario, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Hassan, Brekhna, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Gottlieb, David, Ritchie, David S., Seymour, John F., Vari, Frank, Crooks, Pauline, Burrows, Scott R. and Gandhi, Maher K. 2016. The impact of HLA-class I and EBV-latency-II antigen-specific CD8+T-cells on the pathogenesis of EBV+ Hodgkin Lymphoma. Clinical and Experimental Immunology 183 (2) , pp. 206-220. 10.1111/cei.12716
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Raman, Marine C. C., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Simmons, Ruth, Donnellan, Zoe, Dukes, Joseph, Bossi, Giovanna, Le Provost, Gabrielle S., Todorov, Penio, Baston, Emma, Hickman, Emma, Mahon, Tara, Hassan, Namir, Vuidepot, Annelise, Sami, Malkit, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Jakobsen, Bent K. 2016. Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. Scientific Reports 6 , 18851. 10.1038/srep18851
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Tsai, M.-H., Muenchhoff, M., Adland, E., Carlqvist, A., Roider, J., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Carlson, J., Ndung'u, T. and Goulder, P. J. R. 2016. Paediatric non-progression following grandmother-to-child HIV transmission. Retrovirology 13 (1) , p. 65. 10.1186/s12977-016-0300-y
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Holland, Christopher J., Dolton, Garry M., Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Schauenburg, Andrea J., Miners, Kelly, Madura, Florian, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew J. ORCID: https://orcid.org/0000-0002-1910-7567 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195 (12) , pp. 5827-5836. 10.4049/jimmunol.1402787
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Dolton, Garry Michael, Tungatt, Katie, Lloyd, Angharad, Bianchi, Valentina, Theaker, Sarah M., Trimby, Andrew R., Holland, Christopher J., Donia, Marco, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Straten, Per Thor, Peakman, Mark, Svane, Inge Marie and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1) , pp. 11-22. 10.1111/imm.12499

Neller, Michelle A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, van Baarle, Debbie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Miles, John James 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp. 625-633. 10.1038/icb.2015.17
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Motozono, Chihiro, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, De Leenheer, Evy, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Trimby, Andrew, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290 (31) , pp. 18924-18933. 10.1074/jbc.M114.622522
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Attaf, Meriem, Legut, Mateusz, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. The T cell antigen receptor: the Swiss army knife of the immune. Clinical and Experimental Immunology 181 (1) , pp. 1-18. 10.1111/cei.12622
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2015. The ultimate mix and match: making sense of HLA alleles and peptide repertoires. Immunology and Cell Biology 93 , pp. 515-516. 10.1038/icb.2015.40

Madura, Florian, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Holland, Christopher J., Fuller, Anna, Bulek, Anna Marta, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Schauenburg, Andrea J., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45 (2) , pp. 584-591. 10.1002/eji.201445114
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Straetemans, Trudy, Berrevoets, Cor, Coccoris, Miriam, Treffers-Westerlaken, Elike, Wijers, Rebecca, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dardalhon, Valerie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Taylor, Naomi, Verweij, Jaap and Debets, Reno 2015. Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment. Molecular Therapy 23 (2) , pp. 396-406. 10.1038/mt.2014.215

Tungatt, Katie, Bianchi, Valentina, Crowther, Michael D., Powell, Wendy ORCID: https://orcid.org/0000-0002-4670-1406, Schauenburg, Andrea J. A., Trimby, Andrew R., Donia, M., Miles, John James, Holland, Christopher J., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Peakman, M., Straten, P. T., Svane, I. M., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Dolton, Garry Michael 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194 (1) , pp. 463-474. 10.4049/jimmunol.1401785
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Knight, R. R., Dolton, Garry Michael, Kronenberg-Versteeg, D., Eichmann, M., Zhao, M., Huang, G. C., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Skowera, A. and Peakman, M. 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179 (1) , pp. 100-107. 10.1111/cei.12436

Legut, Mateusz, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy. Cellular and Molecular Immunology 12 , pp. 656-668. 10.1038/cmi.2015.28
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Kløverpris, Henrik N., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Fuller, Anna, Carlson, Jonathan, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Schauenburg, Andrea J. A., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Buus, Søren, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Goulder, Philip 2015. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12 (1) , 20. 10.1186/s12977-015-0149-5
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Stepanek, Ondrej, Prabhakar, Arvind S., Osswald, Celine, King, Carolyn G., Bulek, Anna Marta, Naeher, Dieter, Beaufils-Hugot, Marina, Abanto, Michael L., Galati, Virginie, Hausmann, Barbara, Lang, Rosemarie, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Huseby, Eric S., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Chakraborty, Arup K. and Palmer, Ed 2014. Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell 159 (2) , pp. 333-345. 10.1016/j.cell.2014.08.042

Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Neller, M. A., Miles, John James, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Peakman, M. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1) , pp. 47-63. 10.1111/cei.12339
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Motozono, Chihiro, Kuse, N, Sun, X., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Fuller, Anna, Oka, S., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Takiguchi, M. 2014. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. The Journal of Immunology 192 (7) , pp. 3428-3434. 10.4049/jimmunol.1302667
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Bhati, Mugdha, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, McCluskey, James, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 2014. The versatility of the αβ T-cell antigen receptor. Protein Science 23 (3) , pp. 260-272. 10.1002/pro.2412

van den Berg, Hugo A., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly, Laugel, Bruno, Llewellyn-Lacey, Sian, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S. and Price, David ORCID: https://orcid.org/0000-0001-9416-2737 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4 , 250. 10.3389/fimmu.2013.00250
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Holland, Christopher J., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 2013. Re-directing CD4+ T cell responses with the flanking residues of MHC class II-bound peptides: The core is not enough. Frontiers in Immunology 4 , 172. 10.3389/fimmu.2013.00172
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sami, Malkit, Scott, David, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Borbulevych, Oleg Y., Todorov, Penio T., Moysey, Ruth K., Jakobsen, Bent K., Boulter, Jonathan M., Baker, Brian M. and Li, Yi 2013. Increased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking mode. Frontiers in Immunology 4 , 168. 10.3389/fimmu.2013.00168
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Madura, Florian, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Miles, Kim Michelle, Holland, Christopher J., Bulek, Anna Marta, Fuller, Anna, Schauenburg, Andrea J. A., Miles, John James, Liddy, Nathaniel, Sami, M., Li, Y., Hossain, M., Baker, B. M., Jakobsen, B. K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2013. T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry 288 (26) , pp. 18766-18775. 10.1074/jbc.M113.464560

Eukeruche-Makinde, Julia, Miles, John J., Van Den Berg, Hugo A., Skowera, Ania, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Dolton, Garry Michael, Schauenburg, Andrea, Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim M., Bulek, Anna, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Dockree, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Burrows, Scott, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Ekeruche, Julia, Miles, John James, van den Berg, Hugo A., Skowera, Ania, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dolton, Garry Michael, Schauenburg, Andrea J. A., Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim Michelle, Bulek, Anna Marta, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Williams, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Burrows, Scott R., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Miles, Kim Michelle, Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Bulek, Anna Marta, Fuller, Anna, Akpovwa, Hephzibah, Pymm, Phillip G., Liddy, N., Sami, M., Li, Y., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Jakobsen, B. K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289 (2) , pp. 628-638. 10.1074/jbc.M113.522110
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Knight, Robin R., Kronenberg, Deborah, Zhao, Min, Huang, Guo Cai, Eichmann, Martin, Bulek, Anna Marta, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Peakman, Mark and Skowera, Ania 2013. Human β-cell killing by autoreactive preproinsulin-specific cd8 t cells is predominantly granule-mediated with the potency dependent upon t-cell receptor avidity. Diabetes 62 (1) , pp. 205-213. 10.2337/db12-0315

Matthews, Philippa C., Koyanagi, Madoka, Kloverpris, Henrik N., Harndahl, Mikkel, Stryhn, Anette, Akahoshi, Tomohiro, Gatanaga, Hiroyuki, Oka, Shinichi, Juarez Molina, Claudia, Valenzuela Ponce, Humberto, Avila Rios, Santiago, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Carlson, Jonathan, Payne, Rebecca P., Ogwu, Anthony, Bere, Alfred, Ndung'u, Thumbi, Gounder, Kamini, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Shapiro, Roger, Brander, Christian, Walker, Bruce, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Reyes Teran, Gustavo, Heckerman, David, Hunter, Eric, Buus, Søren, Takiguchi, Masafumi and Goulder, Philip J. R. 2012. Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single gag epitope. Journal of Virology 86 (23) , pp. 12643-12654. 10.1128/JVI.01381-12
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Ekeruche, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John James, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry Michael, Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Ekeruche-Makinde, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Laugel, Bruno Frederic, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

Holland, Christopher J., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Stern, Lawrence J., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2 , 629. 10.1038/srep00629

Bulek, Anna Marta, Madura, Florian, Fuller, Anna, Holland, Christopher J., Schauenburg, Andrea J. A., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2012. TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods 382 (1-2) , pp. 203-210. 10.1016/j.jim.2012.06.007

Bulek, Anna, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Drijfhout, Jan W, Knight, Robin R, Huang, Guo C, Lissin, Nikolai, Molloy, Peter E, Wooldridge, Linda, Jakobsen, Bent K, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206

Bulek, Anna Marta, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Skowera, Ania, Dolton, Garry Michael, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John James, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Gougeon, Marie-Lise and Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665

Bridgeman, John S., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Miles, John James, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2012. Structural and biophysical determinants of ab T-cell antigen recognition. Immunology 135 (1) , pp. 9-18. 10.1111/j.1365-2567.2011.03515.x

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Miles, John James, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Agnew, C., Borodina, E., Zaccai, N. R., Conners, R., Burton, N. M., Vicary, J. A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Antognozzi, M., Virji, M. and Brady, R. L. 2011. Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding. Proceedings of the National Academy of Sciences of the United States of America 108 (37) , pp. 15174-15178. 10.1073/pnas.1106341108

Miles, Kim Michelle, Miles, John James, Madura, Florian, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2011. Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular Immunology 48 (4) , pp. 728-732. 10.1016/j.molimm.2010.11.004

Laugel, Bruno Frederic, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90 (6) , pp. 1089-1099. 10.1189/jlb.0611316

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Wynn, Katherine, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Miles, John James, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185 (4) , pp. 2600-2610. 10.4049/jimmunol.1000629

Wooldridge, Linda, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Lissina, Anna, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Hewitt, R. E., Laugel, Bruno Frederic, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Debets, R., Berrevoets, C., Miles, John James, Burrows, S. R., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184 (7) , pp. 3357-3366. 10.4049/jimmunol.0902398

Miles, John James, Bulek, Anna Marta, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gostick, Emma, Schauenburg, Andrea J. A., Dolton, Garry Michael, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott R., Wooldridge, Linda, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6 (11) , e1001198. 10.1371/journal.ppat.1001198
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Borbulevych, Oleg Y., Piepenbrink, Kurt H., Gloor, Brian E., Scott, Daniel R., Sommese, Ruth F., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Baker, Brian M. 2009. T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity 31 (6) , pp. 885-896. 10.1016/j.immuni.2009.11.003

Hoffman, M., Hickling, Steven, Filby, A., Wilburg, C., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Turner, A., Sims, S., McLean, Andrew, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Klenerman, P., Frater, J. and Phillips, R. E. 2009. Novel tetramer technology for the detection of high affinity CD8 T cells [Conference poster abstract]. Retrovirology 6 (S3) , P409. 10.1186/1742-4690-6-S3-P409

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Yuan, Fang, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Miles, John James, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Gao, George F., Jakobsen, Bent K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284 (40) , 27281-27289. 10.1074/jbc.M109.022509

Choudhuri, K., Parker, M., Milicic, A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Shaw, M. K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Stewart-Jones, G., Dong, T., Gould, K. G. and van der Merwe, P. A. 2009. Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation. Journal of Biological Chemistry 284 (38) , pp. 26096-26105. 10.1074/jbc.M109.039966

Horlock, Claire, Stott, Bryony, Dyson, Julian, Ogg, Graham, McPherson, Tess, Jones, Louise, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Stebbing, Justin and Savage, Philip 2009. ELISPOT and functional T cell analyses using HLA mono-specific target cells. Journal of Immunological Methods 350 (1-2) , pp. 150-160. 10.1016/j.jim.2009.08.011

Wooldridge, Linda, Lissina, Anna, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126 (2) , pp. 147-164. 10.1111/j.1365-2567.2008.02848.x

Varela-Rohena, Angel, Molloy, Peter E., Dunn, Steven M., Li, Yi, Suhoski, Megan M., Carroll, Richard G., Milicic, Anita, Mahon, Tara, Sutton, Deborah H., Laugel, Bruno, Moysey, Ruth, Cameron, Brian J., Vuidepot, Annelise, Purbhoo, Marco A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Phillips, Rodney E., June, Carl H., Jakobsen, Bent K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Riley, James L. 2008. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature Medicine 14 (12) , pp. 1390-1395. 10.1038/nm.1779

Melenhorst, J. Joseph, Scheinberg, Phillip, Chattopadhyay, Pratip K., Lissina, Anna, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Wooldridge, Linda, van den Berg, Hugo A., Bornstein, Ethan, Hensel, Nancy F., Douek, Daniel C., Roederer, Mario, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Barrett, A. John and Price, David ORCID: https://orcid.org/0000-0001-9416-2737 2008. Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of Immunological Methods 338 (1-2) , pp. 31-39. 10.1016/j.jim.2008.07.008

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dunn, Steven M., Sami, Malkit, Boulter, Jonathan M., Jakobsen, Bent K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2008. T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding. Molecular Immunology 45 (9) , pp. 2700-2709. 10.1016/j.molimm.2007.12.009

Laugel, Bruno Frederic, Berg, Hugo A. van den, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Wooldridge, Linda, Boulter, Jonathan M, Milicic, Anita, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties. The Journal of Biological Chemistry 282 (33) , pp. 23799-22810. 10.1074/jbc.M700976200
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Pumphrey, Nicholas J., Boulter, Jonathan M., Sami, Malkit, Bell, John I., Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Gao, George F., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Jakobsen, Bent K. 2007. Human TCR-binding affinity is governed by MHC class restriction. The Journal of Immunology 178 (9) , pp. 5727-5734. 10.4049/​jimmunol.178.9.5727

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Boulter, Jonathan M., Sami, Malkit, Vuidepot, Anne-lise, Glick, Meir, Gao, Feng, Bell, John I., Jakobsen, Bent K. and Gao, George F. 2007. Computational design and crystal structure of an enhanced affinity mutant human CD8 αα coreceptor. Proteins: Structure, Function and Bioinformatics 67 (1) , pp. 65-74. 10.1002/prot.21176

Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Hutchinson, Sarah L., Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno Frederic, Lissina, A., Oxenius, Annette, Boulter, Jonathan M., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology 37 (2) , pp. 479-486. 10.1002/eji.200636243

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Gao, Feng, Watson, Neil I., Boulter, Jonathan M., Bell, John I., Sami, Malkit, Gao, George F. and Jakobsen, Bent K. 2006. Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European Journal of Immunology 36 (1) , pp. 170-179. 10.1002/eji.200535424

Wang, H. W., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Jiang, W. Z., Jin, H. T., Fu, N., Chen, Z. L. and Jin, N. Y. 2005. Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120. Clinical and Experimental Immunology 141 (1) , pp. 72-80. 10.1111/j.1365-2249.2005.02826.x

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Sami, Malkit, Lissin, Nikolai M., Gao, Feng, Bell, John I., Boulter, Jonathan M., Glick, Meir, Vuidepot, Anne-Lise, Jakobsen, Bent K. and Gao, George F. 2005. Crystallization and preliminary X-ray structural studies of a high-affinity CD8αα co-receptor to pMHC. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61 (3) , pp. 285-287. 10.1107/S1744309105002988

Xu, Yanhui, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lou, Zhiyong, Liu, Yiwei, Qin, Lan, Li, Xu, Bai, Zhihong, Yuan, Fang, Rao, Zihe and Gao, George F. 2004. Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein. Protein Expression and Purification 38 (1) , pp. 116-122. 10.1016/j.pep.2004.08.005

Wang, Xiaojia, Xu, Yanhui, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lou, Zhiyong, Liu, Yiwei, Rao, Zihe, Wang, Ming and Gao, George F. 2004. Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein. Acta Crystallographica Section D: Biological Crystallography 60 (9) , pp. 1632-1635. 10.1107/S0907444904015872

Zhou, Minghai, Xu, Yanhui, Lou, Zhiyong, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Li, Xiaojuan, Liu, Yiwei, Tien, Po, Rao, Zihe and Gao, George F. 2004. Complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2Kd complexed with an HBV-core nonapeptide. Acta Crystallographica Section D: Biological Crystallography 60 (8) , pp. 1473-1475. 10.1107/S0907444904013587

Yan, Huimin, Xiao, Gengfu, Zhang, Jiamin, Hu, Yuanyang, Yuan, Fang, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Zheng, Congyi and Gao, George F. 2004. SARS coronavirus induces apoptosis in Vero E6 Cells. Journal of Medical Virology 73 (3) , pp. 323-331. 10.1002/jmv.20094

Zhu, Jieqing, Xiao, Gengfu, Xu, Yanhui, Yuan, Fang, Zheng, Congyi, Liu, Yueyong, Yan, Huimin, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Bell, John I., Rao, Zihe, Tien, Po and Gao, George F. 2004. Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors. Biochemical and Biophysical Research Communications 319 (1) , pp. 283-288. 10.1016/j.bbrc.2004.04.141

Xu, Yanhui, Lou, Zhiyong, Liu, Yiwei, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Su, Nan, Qin, Lan, Li, Xu, Bai, Zhihong, Rao, Zihe and Gao, George F. 2004. Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus. Acta Crystallographica Section D: Biological Crystallography 60 (6) , pp. 1161-1164. 10.1107/S0907444904009515

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Gao, George F. 2004. CD8: adhesion molecule, co-receptor and immuno-modulator [Review]. Cellular and Molecular Immunology 1 (2) , pp. 81-88.

Xu, Yanhui, Gao, Shan, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Zhu, Junjie, Su, Nan, Wang, Hui, Gao, George F. and Rao, Zihe 2004. Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses. Biochemical and Biophysical Research Communications 315 (3) , pp. 664-670. 10.1016/j.bbrc.2004.01.115

Xu, Yanhui, Zhu, Jieqing, Liu, Yiwei, Lou, Zhiyong, Yuan, Fang, Liu, Yueyong, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Ni, Ling, Su, Nan, Qin, Lan, Li, Xu, Bai, Zhihong, Bell, John I., Pang, Hai, Tien, Po, Gao, George F. and Rao, Zihe 2004. Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus. Biochemistry 43 (44) , pp. 14064-14071. 10.1021/bi049101q

This list was generated on Tue Mar 19 04:34:15 2024 GMT.