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Number of items: 32.

Precious, Sophie V., Smith, Gaynor A., Heuer, Andreas, Jaeger, Ines, Lane, Emma L., Dunnett, Stephen B., Li, Meng, Kelly, Claire M. and Rosser, Anne E. 2020. Dopaminergic progenitors derived from epiblast stem cells function similarly to primary VM-derived progenitors when transplanted into a Parkinson’s disease model. Frontiers in Neuroscience 14 , 312. 10.3389/fnins.2020.00312

Malik, Bilal R., Maddison, Daniel C., Smith, Gaynor A. and Peters, Owen M. 2019. Autophagic and endo-lysosomal dysfunction in neurodegenerative disease. Molecular Brain 12 (1) , 100. 10.1186/s13041-019-0504-x

Smith, Gaynor A., Lin, Tzu-Huai, Sheehan, Amy E., Van Der Goes Van Naters, Wynand, Neukomm, Lukas J., Graves, Hillary K., Bis-Brewer, Dana M., Zuchner, Stephan and Freeman, Marc R. 2019. Glutathione-S-transferase regulates mitochondrial populations in axons through increased glutathione oxidation. Neuron 103 (1) , 52-65.e6. 10.1016/j.neuron.2019.04.017

Breger, Ludivine S., Kienle, Korbinian, Smith, Gaynor A., Dunnett, Stephen B. and Lane, Emma L. 2017. Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease. Brain, Behavior, and Immunity 61 , pp. 155-164. 10.1016/j.bbi.2016.11.014

Smith, G. A., Jansson, J., Rocha, E. M., Osborn, T., Hallett, P. J. and Isacson, O. 2016. Fibroblast biomarkers of sporadic Parkinson's Disease and LRRK2 kinase inhibition. Molecular Neurobiology 53 (8) , pp. 5161-5177. 10.1007/s12035-015-9435-4

Lewis, Elizabeth A. and Smith, Gaynor A. 2016. Using Drosophila models of Huntington's disease as a translatable tool. Journal of Neuroscience Methods 265 , pp. 89-98. 10.1016/j.jneumeth.2015.07.026

Rocha, Emily M., Smith, Gaynor A., Park, Eric, Cao, Hongmei, Brown, Eilish, Hayes, Melissa A., Beagan, Jonathan, McLean, Jesse R., Izen, Sarah C., Perez-Torres, Eduardo, Hallett, Penelope J. and Isacson, Ole 2015. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease 82 , pp. 495-503. 10.1016/j.nbd.2015.09.009

Rocha, Emily M., Smith, Gaynor A., Park, Eric, Cao, Hongmei, Graham, Anne-Renee, Brown, Eilish, McLean, Jesse R., Hayes, Melissa A., Beagan, Jonathan, Izen, Sarah C., Perez-Torres, Eduardo, Hallett, Penelope J. and Isacson, Ole 2015. Sustained systemic glucocerebrosidase inhibition induces brain α-Synuclein aggregation, microglia and complement C1q activation in mice. Antioxidants and Redox Signaling 23 (6) , pp. 550-564. 10.1089/ars.2015.6307

Rocha, Emily M., Smith, Gaynor A., Park, Eric, Cao, Hongmei, Brown, Eilish, Hallett, Penelope and Isacson, Ole 2015. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Annals of Clinical and Translational Neurology 2 (4) , pp. 433-438. 10.1002/acn3.177

Smith, Gaynor A., Rocha, Emily M., Rooney, Thomas, Barneoud, Pascal, McLean, Jesse R., Beagan, Jonathan, Osborn, Teresia, Coimbra, Madeleine, Luo, Yongyi, Hallett, Penelope J. and Isacson, Ole 2015. A nurr1 agonist causes neuroprotection in a Parkinson's Disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). PLoS ONE 10 (3) , e0121072. 10.1371/journal.pone.0121072

Hallett, Penelope J., Deleidi, Michela, Astradsson, Arnar, Smith, Gaynor A., Cooper, Oliver, Osborn, Teresia M., Sundberg, Maria, Moore, Michele A., Perez-Torres, Eduardo, Brownell, Anna-Liisa, Schumacher, James M., Spealman, Roger D. and Isacson, Ole 2015. Successful function of Autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell 16 (3) , pp. 269-274. 10.1016/j.stem.2015.01.018

McLean, Jesse R., Smith, Gaynor A., Rocha, Emily M., Osborn, Teresia M., Dib, Samar, Hayes, Melissa A., Beagan, Jonathan A., Brown, Tana B., Lawson, Tristan F.S., Hallett, Penelope J., Robertson, Janice and Isacson, Ole 2014. ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Experimental Neurology 261 , pp. 217-229. 10.1016/j.expneurol.2014.05.024

Smith, G. A., Rocha, E. M., McLean, J. R., Hayes, M. A., Izen, S. C., Isacson, O. and Hallett, P. J. 2014. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human Molecular Genetics 23 (17) , pp. 4510-4527. 10.1093/hmg/ddu166

McLean, Jesse R., Smith, Gaynor A., Rocha, Emily M., Hayes, Melissa A., Beagan, Jonathan A., Hallett, Penelope J. and Isacson, Ole 2014. Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience Letters. 576 , pp. 73-78. 10.1016/j.neulet.2014.05.044

Davies, Sian E., Hallett, Penelope J., Moens, Thomas, Smith, Gaynor, Mangano, Emily, Kim, Hyoung Tae, Goldberg, Alfred L., Liu, Ji-Long, Isacson, Ole and Tofaris, George K. 2014. Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiology of Disease 64 , pp. 79-87. 10.1016/j.nbd.2013.12.011

Smith, Gaynor A. and Snyder, Evan Y. 2013. Two cells are better than one: optimizing stem cell survival by co-grafting “helper” cells that offer regulated trophic support. Experimental Neurology 247 , pp. 751-754. 10.1016/j.expneurol.2013.07.003

Peters, Owen Morgan, Shelkovnikova, Tatyana, Tarasova, Tatiana, Springe, Signe, Kukharsky, Michail S., Smith, Gaynor A., Brooks, Simon Philip, Kozin, Sergey A., Kotelevtsev, Yury, Bachurin, Sergey O., Ninkina, Natalia and Buchman, Vladimir L. 2013. Chronic administration of dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's Disease 36 (3) , pp. 589-596. 10.3233/JAD-130071

Heuer, Andreas, Smith, Gaynor A. and Dunnett, Stephen Bruce 2013. Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice. European Journal of Neuroscience 37 (2) , pp. 294-302. 10.1111/ejn.12036

Sundberg, Maria, Bogetofte, Helle, Lawson, Tristan, Jansson, Johan, Smith, Gaynor A., Astradsson, Arnar, Moore, Michele, Osborn, Teresia, Cooper, Oliver, Spealman, Roger, Hallett, Penelope and Isacson, Ole 2013. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells 31 (8) , pp. 1548-152. 10.1002/stem.1415

Smith, Gaynor A., Isacson, Ole and Dunnett, Stephen Bruce 2012. The search for genetic mouse models of prodromal Parkinson's disease. Experimental Neurology 237 (2) , pp. 267-273. 10.1016/j.expneurol.2012.06.035

Smith, Gaynor A., Breger, Ludivine S., Lane, Emma Louise and Dunnett, Stephen Bruce 2012. Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats. Neuropharmacology 63 (5) , pp. 818-828. 10.1016/j.neuropharm.2012.06.011

Smith, Gaynor A., Dunnett, Stephen Bruce and Lane, Emma Louise 2012. Amphetamine-induced rotation in the transplanted hemi-parkinsonian rat - Response to pharmacological modulation. Behavioural Brain Research 232 (2) , pp. 411-415. 10.1016/j.bbr.2012.04.003

Heuer, Andreas, Smith, Gaynor A., Lelos, Mariah Jillian, Lane, Emma Louise and Dunnett, Stephen Bruce 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural Brain Research 228 (1) , pp. 30-43. 10.1016/j.bbr.2011.11.027

Smith, Gaynor A., Heuer, Andreas, Dunnett, Stephen Bruce and Lane, Emma Louise 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: Predicting L-DOPA-induced dyskinesia. Behavioural Brain Research 226 (1) , pp. 281-292. 10.1016/j.bbr.2011.09.025

Smith, Gaynor Ann, Heuer, Andreas, Klein, Alex, Vinh, Ngoc-Nga, Dunnett, Stephen B and Lane, Emma 2012. Amphetamine-induced dyskinesia in the transplanted hemi-Parkinsonian mouse. Journal of Parkinson's Disease 2 , pp. 107-113. 10.3233/JPD-2012-12102

Smith, Gaynor A., Heuer, Andreas, Precious, Sophie Victoria, Klein, Alexander, Jaeger, Ines, Kelly, Claire, Lane, Emma Louise, Li, Meng and Dunnett, Stephen Bruce 2012. L-dopa and graft-induced dyskinesia in the 6-OHDA-lesioned mouse [Abstract]. Cell Transplantation 21 (4) , p. 792.

Torres, Eduardo Miguel, Lane, Emma Louise, Heuer, Andreas, Smith, Gaynor A., Murphy, Ellen M. and Dunnett, Stephen Bruce 2011. Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates. Journal of Neuroscience Methods 200 (1) , pp. 29-35. 10.1016/j.jneumeth.2011.06.012

Lane, Emma Louise, Daly, Carl S., Smith, Gaynor A. and Dunnett, Stephen Bruce 2011. Context-driven changes in 1-DOPA-induced behaviours in the 6-OHDA lesioned rat. Neurobiology of Disease 42 (1) , pp. 99-107. 10.1016/j.nbd.2011.01.010

Smith, Gaynor A., Lane, Emma Louise and Dunnett, Stephen Bruce 2011. Graft-Induced Dyskinesia in Transplanted Hemiparkinsonian Mice and Rats: A Pharmacological Manipulation [Abstract]. Cell Transplantation 20 (4) , p. 585.

Smith, Gaynor A., Breger, Ludivine S., Dunnett, Stephen Bruce and Lane, Emma Louise 2011. Developments in Graft-Induced Dyskinesia [Abstract]. Cell Transplantation 20 (4) , pp. 584-585.

Smith, Gaynor 2011. Optimisation and mechanistic insights of dyskinesia in rodent models of Parkinson’s disease. PhD Thesis, Cardiff University.
Item availability restricted.

Lane, Emma Louise and Smith, Gaynor A. 2010. Understanding graft-induced dyskinesia. Regenerative Medicine 5 (5) , pp. 787-797. 10.2217/rme.10.42

This list was generated on Mon Jan 25 04:17:29 2021 GMT.

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