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Precious, Sophie V., Smith, Gaynor A., Heuer, Andreas, Jaeger, Ines, Lane, Emma L., Dunnett, Stephen B., Li, Meng, Kelly, Claire M. and Rosser, Anne E.
2020.
Dopaminergic progenitors derived from epiblast stem cells function similarly to primary VM-derived progenitors when transplanted into a Parkinson’s disease model.
Frontiers in Neuroscience
14
, 312.
10.3389/fnins.2020.00312
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Malik, Bilal R., Maddison, Daniel C., Smith, Gaynor A. and Peters, Owen M.
2019.
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
Molecular Brain
12
(1)
, 100.
10.1186/s13041-019-0504-x
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Smith, Gaynor A., Lin, Tzu-Huai, Sheehan, Amy E., Van Der Goes Van Naters, Wynand, Neukomm, Lukas J., Graves, Hillary K., Bis-Brewer, Dana M., Zuchner, Stephan and Freeman, Marc R.
2019.
Glutathione-S-transferase regulates mitochondrial populations in axons through increased glutathione oxidation.
Neuron
103
(1)
, 52-65.e6.
10.1016/j.neuron.2019.04.017
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Breger, Ludivine S., Kienle, Korbinian, Smith, Gaynor A., Dunnett, Stephen B. and Lane, Emma L.
2017.
Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease.
Brain, Behavior, and Immunity
61
, pp. 155-164.
10.1016/j.bbi.2016.11.014
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Smith, G. A., Jansson, J., Rocha, E. M., Osborn, T., Hallett, P. J. and Isacson, O. 2016. Fibroblast biomarkers of sporadic Parkinson's Disease and LRRK2 kinase inhibition. Molecular Neurobiology 53 (8) , pp. 5161-5177. 10.1007/s12035-015-9435-4 |
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Lewis, Elizabeth A. and Smith, Gaynor A. 2016. Using Drosophila models of Huntington's disease as a translatable tool. Journal of Neuroscience Methods 265 , pp. 89-98. 10.1016/j.jneumeth.2015.07.026 |
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Rocha, Emily M., Smith, Gaynor A., Park, Eric, Cao, Hongmei, Brown, Eilish, Hayes, Melissa A., Beagan, Jonathan, McLean, Jesse R., Izen, Sarah C., Perez-Torres, Eduardo, Hallett, Penelope J. and Isacson, Ole 2015. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease 82 , pp. 495-503. 10.1016/j.nbd.2015.09.009 |
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Rocha, Emily M., Smith, Gaynor A., Park, Eric, Cao, Hongmei, Graham, Anne-Renee, Brown, Eilish, McLean, Jesse R., Hayes, Melissa A., Beagan, Jonathan, Izen, Sarah C., Perez-Torres, Eduardo, Hallett, Penelope J. and Isacson, Ole
2015.
Sustained systemic glucocerebrosidase inhibition induces brain α-Synuclein aggregation, microglia and complement C1q activation in mice.
Antioxidants and Redox Signaling
23
(6)
, pp. 550-564.
10.1089/ars.2015.6307
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Rocha, Emily M., Smith, Gaynor A., Park, Eric, Cao, Hongmei, Brown, Eilish, Hallett, Penelope and Isacson, Ole 2015. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Annals of Clinical and Translational Neurology 2 (4) , pp. 433-438. 10.1002/acn3.177 |
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Smith, Gaynor A., Rocha, Emily M., Rooney, Thomas, Barneoud, Pascal, McLean, Jesse R., Beagan, Jonathan, Osborn, Teresia, Coimbra, Madeleine, Luo, Yongyi, Hallett, Penelope J. and Isacson, Ole 2015. A nurr1 agonist causes neuroprotection in a Parkinson's Disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). PLoS ONE 10 (3) , e0121072. 10.1371/journal.pone.0121072 |
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Hallett, Penelope J., Deleidi, Michela, Astradsson, Arnar, Smith, Gaynor A., Cooper, Oliver, Osborn, Teresia M., Sundberg, Maria, Moore, Michele A., Perez-Torres, Eduardo, Brownell, Anna-Liisa, Schumacher, James M., Spealman, Roger D. and Isacson, Ole 2015. Successful function of Autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell 16 (3) , pp. 269-274. 10.1016/j.stem.2015.01.018 |
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McLean, Jesse R., Smith, Gaynor A., Rocha, Emily M., Osborn, Teresia M., Dib, Samar, Hayes, Melissa A., Beagan, Jonathan A., Brown, Tana B., Lawson, Tristan F.S., Hallett, Penelope J., Robertson, Janice and Isacson, Ole 2014. ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Experimental Neurology 261 , pp. 217-229. 10.1016/j.expneurol.2014.05.024 |
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Smith, G. A., Rocha, E. M., McLean, J. R., Hayes, M. A., Izen, S. C., Isacson, O. and Hallett, P. J. 2014. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human Molecular Genetics 23 (17) , pp. 4510-4527. 10.1093/hmg/ddu166 |
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McLean, Jesse R., Smith, Gaynor A., Rocha, Emily M., Hayes, Melissa A., Beagan, Jonathan A., Hallett, Penelope J. and Isacson, Ole 2014. Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience Letters. 576 , pp. 73-78. 10.1016/j.neulet.2014.05.044 |
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Davies, Sian E., Hallett, Penelope J., Moens, Thomas, Smith, Gaynor, Mangano, Emily, Kim, Hyoung Tae, Goldberg, Alfred L., Liu, Ji-Long, Isacson, Ole and Tofaris, George K.
2014.
Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.
Neurobiology of Disease
64
, pp. 79-87.
10.1016/j.nbd.2013.12.011
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Smith, Gaynor A. and Snyder, Evan Y. 2013. Two cells are better than one: optimizing stem cell survival by co-grafting “helper” cells that offer regulated trophic support. Experimental Neurology 247 , pp. 751-754. 10.1016/j.expneurol.2013.07.003 |
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Peters, Owen Morgan, Shelkovnikova, Tatyana, Tarasova, Tatiana, Springe, Signe, Kukharsky, Michail S., Smith, Gaynor A., Brooks, Simon Philip, Kozin, Sergey A., Kotelevtsev, Yury, Bachurin, Sergey O., Ninkina, Natalia and Buchman, Vladimir L. 2013. Chronic administration of dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's Disease 36 (3) , pp. 589-596. 10.3233/JAD-130071 |
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Heuer, Andreas, Smith, Gaynor A. and Dunnett, Stephen Bruce 2013. Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice. European Journal of Neuroscience 37 (2) , pp. 294-302. 10.1111/ejn.12036 |
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Sundberg, Maria, Bogetofte, Helle, Lawson, Tristan, Jansson, Johan, Smith, Gaynor A., Astradsson, Arnar, Moore, Michele, Osborn, Teresia, Cooper, Oliver, Spealman, Roger, Hallett, Penelope and Isacson, Ole 2013. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells 31 (8) , pp. 1548-152. 10.1002/stem.1415 |
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Smith, Gaynor A., Isacson, Ole and Dunnett, Stephen Bruce 2012. The search for genetic mouse models of prodromal Parkinson's disease. Experimental Neurology 237 (2) , pp. 267-273. 10.1016/j.expneurol.2012.06.035 |
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Smith, Gaynor A., Breger, Ludivine S., Lane, Emma Louise and Dunnett, Stephen Bruce 2012. Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats. Neuropharmacology 63 (5) , pp. 818-828. 10.1016/j.neuropharm.2012.06.011 |
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Smith, Gaynor A., Dunnett, Stephen Bruce and Lane, Emma Louise 2012. Amphetamine-induced rotation in the transplanted hemi-parkinsonian rat - Response to pharmacological modulation. Behavioural Brain Research 232 (2) , pp. 411-415. 10.1016/j.bbr.2012.04.003 |
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Heuer, Andreas, Smith, Gaynor A., Lelos, Mariah Jillian, Lane, Emma Louise and Dunnett, Stephen Bruce 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural Brain Research 228 (1) , pp. 30-43. 10.1016/j.bbr.2011.11.027 |
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Smith, Gaynor A., Heuer, Andreas, Dunnett, Stephen Bruce and Lane, Emma Louise 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: Predicting L-DOPA-induced dyskinesia. Behavioural Brain Research 226 (1) , pp. 281-292. 10.1016/j.bbr.2011.09.025 |
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Smith, Gaynor Ann, Heuer, Andreas, Klein, Alex, Vinh, Ngoc-Nga, Dunnett, Stephen B and Lane, Emma 2012. Amphetamine-induced dyskinesia in the transplanted hemi-Parkinsonian mouse. Journal of Parkinson's Disease 2 , pp. 107-113. 10.3233/JPD-2012-12102 |
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Smith, Gaynor A., Heuer, Andreas, Precious, Sophie Victoria, Klein, Alexander, Jaeger, Ines, Kelly, Claire, Lane, Emma Louise, Li, Meng and Dunnett, Stephen Bruce 2012. L-dopa and graft-induced dyskinesia in the 6-OHDA-lesioned mouse [Abstract]. Cell Transplantation 21 (4) , p. 792. |
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Torres, Eduardo Miguel, Lane, Emma Louise, Heuer, Andreas, Smith, Gaynor A., Murphy, Ellen M. and Dunnett, Stephen Bruce 2011. Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates. Journal of Neuroscience Methods 200 (1) , pp. 29-35. 10.1016/j.jneumeth.2011.06.012 |
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Lane, Emma Louise, Daly, Carl S., Smith, Gaynor A. and Dunnett, Stephen Bruce 2011. Context-driven changes in 1-DOPA-induced behaviours in the 6-OHDA lesioned rat. Neurobiology of Disease 42 (1) , pp. 99-107. 10.1016/j.nbd.2011.01.010 |
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Smith, Gaynor A., Lane, Emma Louise and Dunnett, Stephen Bruce 2011. Graft-Induced Dyskinesia in Transplanted Hemiparkinsonian Mice and Rats: A Pharmacological Manipulation [Abstract]. Cell Transplantation 20 (4) , p. 585. |
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Smith, Gaynor A., Breger, Ludivine S., Dunnett, Stephen Bruce and Lane, Emma Louise 2011. Developments in Graft-Induced Dyskinesia [Abstract]. Cell Transplantation 20 (4) , pp. 584-585. |
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Smith, Gaynor
2011.
Optimisation and mechanistic insights of dyskinesia in rodent models of Parkinson’s disease.
PhD Thesis,
Cardiff University.
Item availability restricted. |
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Lane, Emma Louise and Smith, Gaynor A. 2010. Understanding graft-induced dyskinesia. Regenerative Medicine 5 (5) , pp. 787-797. 10.2217/rme.10.42 |
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