ORCA
Online Research @ Cardiff
Browse by Current Cardiff authors
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Number of items: 25.
Mohamed, Noha-Ehssan, Hay, Trevor, Reed, Karen R., Smalley, Matthew J. and Clarke, Alan R.
2019.
APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.
BMC Cancer
19
, 677.
10.1186/s12885-019-5867-y
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| Young, Madeleine, Daly, Carl, Taylor, Elaine, James, Rhiannon, Clarke, Alan and Reed, Karen 2018. Subtle deregulation of the Wnt-signalling pathway through loss of Apc2 reduces the fitness of intestinal stem cells. Stem Cells 36 (1) , pp. 114-122. 10.1002/stem.2712 |
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| Burke, Zoë D., Reed, Karen R., Yeh, Sheng-Wen, Meniel, Valerie, Sansom, Owen J., Clarke, Alan R. and Tosh, David 2018. Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway. Scientific Reports 8 (1) 10.1038/s41598-018-20888-y |
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| Burke, Zoe D., Reed, Karen Ruth, Yeh, Sheng-Wen, Meniel, Valerie S., Sansom, Owen J., Clarke, Alan R. and Tosh, David 2018. Spatiotemporal regulation of liver development by the Wnt/β- catenin pathway. Scientific Reports 8 , 2735. 10.1038/s41598-018-20888-y |
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| Daly, C. S., Shaw, Paul, Ordonez, L D, Williams, G T, Quist, J, Grigoriadis, A, Van Es, J H, Clevers, H, Clarke, Alan Richard and Reed, Karen Ruth 2017. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium. Oncogene 36 (13) 10.1038/onc.2016.342 |
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Young, Madeleine and Reed, Karen Ruth
2016.
Organoids as a model for colorectal cancer.
Current Colorectal Cancer Reports
12
(5)
, pp. 281-287.
10.1007/s11888-016-0335-4
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| Reed, Karen Ruth, Song, Fei, Young, Madeleine, Hassan, N., Antoine, A. J., Gemici, Nesibe-Princess B, Clarke, Alan Richard and Jenkins, J. R. 2016. Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype. Oncotarget 7 (32) , pp. 51665-51673. 10.18632/oncotarget.10076 |
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| Huels, D. J., Ridgway, R. A., Radulescu, S., Leushacke, M., Campbell, A. D., Biswas, S., Leedham, S., Serra, S., Chetty, R., Moreaux, G., Parry, Lee, Matthews, James, Song, F., Hedley, A., Kalna, G., Ceteci, F., Reed, Karen Ruth, Meniel, Valerie, Maguire, A., Doyle, B., Soderberg, O., Barker, N., Watson, A., Larue, L., Clarke, Alan Richard and Sansom, O. J. 2015. E-cadherin can limit the transforming properties of activating β‐catenin mutations. EMBO Journal 34 (16) 10.15252/embj.201591739 |
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| Reed, Karen Ruth, Athineos, Dimitris, Meniel, Valerie, Wilkins, Julie A., Ridgway, Rachel A., Burke, Zoe D., Muncan, Vanessa, Clarke, Alan Richard and Sansom, Owen J. 2015. Correction for Reed et al., B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 112 (10) , E1168. 10.1073/pnas.1502294112 |
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| Reed, Karen Ruth, Korobko, Igor, Ninkina, Natalia, Korobko, Elena V., Hopkins, Ben R., Platt, James L., Buchman, Vladimir and Clarke, Alan Richard 2015. Hunk/Mak-v is a negative regulator of intestinal cell proliferation. BMC Cancer 15 , 110. 10.1186/s12885-015-1087-2 |
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| Hammoudi, Abeer, Song, Fei, Reed, Karen Ruth, Jenkins, Rosalind E., Meniel, Valerie, Watson, Alastair J. M., Pritchard, D. Mark, Clarke, Alan Richard and Jenkins, John R. 2013. Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). Biochemical and Biophysical Research Communications 440 (3) , pp. 364-370. 10.1016/j.bbrc.2013.08.076 |
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| Feng, Gui Jie, Cotta, Welwyn, Wei, Xiao-Qing, Poetz, Oliver, Evans, Rebecca Jane, Jardé, Thierry, Reed, Karen Ruth, Meniel, Valerie, Williams, Geraint Trefor, Clarke, Alan Richard and Dale, Trevor Clive 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143 (6) , pp. 1650-1659. 10.1053/j.gastro.2012.08.047 |
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| Reed, Karen Ruth, Tunster, Simon James, Young, Madeleine, Carrico, Adam Stephen, John, Rosalind Margaret and Clarke, Alan Richard 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61 (10) , pp. 1435-1438. 10.1136/gutjnl-2011-300842 |
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| Kant, P., Sainsbury, A., Reed, Karen Ruth, Pollard, S. G., Scott, N., Clarke, Alan Richard, Coletta, P. L. and Hull, M. A. 2011. Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB. Gut 60 (7) , pp. 893-901. 10.1136/gut.2010.230755 |
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| Cole, Alicia M., Myant, Kevin, Reed, Karen Ruth, Ridgway, Rachel A., Athineos, Dimitris, Van den Brink, Gijs, Muncan, Vanesa, Clevers, Hans, Clarke, Alan Richard, Sicinski, Peter and Sansom, Owen J. 2010. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Research 70 (20) , pp. 8149-8158. 10.1158/0008-5472.CAN-10-0315 |
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| Burke, Zoé D., Reed, Karen Ruth, Phesse, Toby, Sansom, Owen J., Clarke, Alan Richard and Tosh, David 2009. Liver zonation occurs through a β-catenin–dependent, c-Myc–independent mechanism. Gastroenterology 136 (7) , pp. 2316-2324. 10.1053/j.gastro.2009.02.063 |
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| Reed, Karen Ruth, Athineos, Dimitris, Meniel, Valerie, Wilkins, Julie Ann, Ridgeway, Rachel A., Burke, Zoe D., Muncan, Vanesa, Clarke, Alan Richard and Sansom, Owen J. 2008. B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 105 (48) , pp. 18919-18923. 10.1073/pnas.0805778105 |
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| Reed, Karen Ruth, Meniel, Valerie, Marsh Durban, Victoria, Cole, Alicia, Sansom, Owen J. and Clarke, Alan Richard 2008. A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 8 , 162. 10.1186/1471-2407-8-162 |
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| Phesse, Toby, Parry, Lee, Reed, Karen Ruth, Ewan, Kenneth Burnside Ramsay, Dale, Trevor Clive, Sansom, Owen J. and Clarke, Alan Richard 2008. Deficiency of Mbd2 attenuates Wnt induced tumourigenesis via deregulation of a novel Wnt inhibitor, Lect.2. Molecular and Cellular Biology 28 (19) , pp. 6094-6103. 10.1128/MCB.00539-08 |
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| Sansom, Owen J., Meniel, Valerie, Muncan, Vanesa, Phesse, Toby, Wilkins, Julie Ann, Reed, Karen Ruth, Vass, Keith, Athineos, Dimitris, Clevers, Hans and Clarke, Alan Richard 2007. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 (7136) , pp. 676-679. 10.1038/nature05674 |
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| Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Peters, Jefferey M. and Clarke, Alan Richard 2006. PPARδ status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer 6 (113) 10.1186/1471-2407-6-113 |
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| Sansom, Owen J., Griffiths, David Francis Rees, Reed, Karen Ruth, Winton, Douglas J. and Clarke, Alan Richard 2005. Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene 24 , pp. 8205-8210. 10.1038/sj.onc.1208956 |
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| Sansom, Owen J., Reed, Karen Ruth, van de Wetering, M., Muncan, V., Winton, D. J., Clevers, H. and Clarke, Alan Richard 2005. Cyclin D1 is not an immediate target of β-Catenin following Apc loss in the intestine. Journal of Biological Chemistry 280 (31) , pp. 28463-28467. 10.1074/jbc.M500191200 |
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| Sansom, Owen J., Reed, Karen, Hayes, Anthony Joseph, Ireland, Heather, Brinkmann, Hannah, Newton, Ian P., Batlle, Edouard, Simon-Assmann, Patricia, Clevers, Hans, Nathke, Inke S, Clarke, Alan Richard and Winton, Douglas J. 2004. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes and Development 18 (12) , pp. 1385-1390. 10.1101/gad.287404 |
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| Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Winton, Douglas J., Peters, Jeffrey M. and Clarke, Alan Richard 2004. PPARδ status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene 23 (55) , pp. 8992-8996. 10.1038/sj.onc.1208143 |
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