ORCA
Online Research @ Cardiff
Browse by Current Cardiff authors
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Number of items: 60.
Moshkelgosha, Sajad, Verhasselt, Hedda Luise, Masetti, Giulia, Covelli, Danila, Biscarini, Filippo, Horstmann, Mareike, Daser, Anke, Westendorf, Astrid M., Jesenek, Christoph, Philipp, Svenja, Diaz-Cano, Salvador, Banga, J. Paul, Michael, Daryn, Plummer, Sue, Marchesi, Julian R., Eckstein, Anja, Ludgate, Marian and Berchner-Pfannschmidt, Utta
2021.
Modulating gut microbiota in a mouse model of Graves' orbitopathy and its impact on induced disease.
Microbiome
9
(1)
, 45.
10.1186/s40168-020-00952-4
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Zhang, Lei, Evans, Anna, von Ruhland, Chris, Draman, Mohd Shazli, Edkins, Sarah, Vincent, Amy E., Berlinguer-Palmini, Rolando, Rees, D. Aled, Haridas, Anjana S, Morris, Dan, Tee, Andrew R., Ludgate, Marian, Turnbull, Doug M., Karpe, Fredrik and Dayan, Colin M.
2020.
Distinctive features of orbital adipose tissue (OAT) in Graves' orbitopathy.
International Journal of Molecular Sciences
21
(23)
, 9145.
10.3390/ijms21239145
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Muller, Ilaria, Taylor, Peter N., Daniel, Rhian M., Hales, Charlotte, Scholz, Anna, Candler, Toby, Pettit, Rebecca J., Evans, William D., Shillabeer, Dionne, Draman, Mohd S., Dayan, Colin M., Tang, Hiu K. C., Okosieme, Onyebuchi, Gregory, John W., Lazarus, John H., Rees, D. Aled and Ludgate, Marian E.
2020.
CATS II long-term anthropometric and metabolic effects of maternal sub-optimal thyroid function in offspring and mothers.
Journal of Clinical Endocrinology and Metabolism
105
(7)
, dgaa129.
10.1210/clinem/dgaa129
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| Ludgate, Marian 2020. Shining a light on thyroid eye disease. Nature Reviews Endocrinology 16 , pp. 259-260. 10.1038/s41574-020-0340-1 |
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| Taylor, Peter N., Zhang, Lei, Lee, Richard W. J., Muller, Ilaria, Ezra, Daniel G., Dayan, Colin M., Kahaly, George J. and Ludgate, Marian 2019. New insights into the pathogenesis and nonsurgical management of Graves orbitopathy. Nature Reviews Endocrinology 16 (2) , pp. 104-116. 10.1038/s41574-019-0305-4 |
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Wilson, Nicholas, Steadman, Robert, Muller, Ilaria, Draman, Mohd, Rees, D. Aled, Taylor, Peter, Dayan, Colin M., Ludgate, Marian and Zhang, Lei
2019.
Role of hyaluronan in human adipogenesis: Evidence from in-vitro and in-vivo studies.
International Journal of Molecular Sciences
20
(11)
, 2675.
10.3390/ijms20112675
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Muller, Ilaria, Willis, Mark, Healy, Sarah, Nasser, Taha, Loveless, Samantha, Butterworth, Sara, Zhang, Lei, Draman, Mohd S., Taylor, Peter N., Robertson, Neil, Dayan, Colin M. and Ludgate, Marian E.
2018.
Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years.
Thyroid
28
(12)
, pp. 1682-1693.
10.1089/thy.2018.0232
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Bakhsh, Ameen D., Ladas, Ioannis, Hamshere, Marian L., Bullock, Martyn, Kirov, George, Zhang, Lei, Taylor, Peter N., Gregory, John W., Scott-Coombes, David, Völzke, Henry, Teumer, Alexander, Mantripragada, Kiran, Williams, E. Dillwyn, Clifton-Bligh, Roderick J., Williams, Nigel M. and Ludgate, Marian E.
2018.
An InDel in Phospholipase-C-B-1 is linked with euthyroid multinodular goiter.
Thyroid
28
(7)
, pp. 891-901.
10.1089/thy.2017.0312
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Zhang, Lei, Masetti, Giulia, Colucci, Giuseppe, Salvi, Mario, Covelli, Danila, Eckstein, Anja, Kaiser, Ulrike, Draman, Mohd Shazli, Muller, Ilaria, Ludgate, Marian, Lucini, Luigi and Biscarini, Filippo
2018.
Combining micro-RNA and protein sequencing to detect robust biomarkers for Graves' disease and orbitopathy.
Scientific Reports
8
(1)
, 8386.
10.1038/s41598-018-26700-1
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Masetti, Giulia, Moshkelgosha, Sajad, Kohling, Hedda-Luise, Covelli, Danila, Banga, Jasvinder Paul, Berchner-Pfannschmidt, Utta, Horstmann, Mareike, Diaz-Cano, Salvador, Goertz, Gina-Eva, Plummer, Sue, Eckstein, Anja, Ludgate, Marian, Biscarini, Filippo and Marchesi, Julian Roberto
2018.
Gut microbiota in experimental murine model of Graves' orbitopathy established in different environments may modulate clinical presentation of disease.
Microbiome
6
, 97.
10.1186/s40168-018-0478-4
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Hales, Charlotte, Taylor, Peter N., Channon, Sue, Paradice, Ruth, McEwan, Kirsten, Zhang, Lei, Gyedu, Michael, Bakhsh, Ameen, Okosieme, Onyebuchi, Muller, Ilaria, Draman, Mohd S., Gregory, John W., Dayan, Colin, Lazarus, John H., Rees, D. Aled and Ludgate, Marian
2018.
Controlled antenatal thyroid screening II: effect of treating maternal sub-optimal thyroid function on child cognition.
Journal of Clinical Endocrinology and Metabolism
103
(4)
, pp. 1583-1591.
10.1210/jc.2017-02378
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| Köhling, Hedda L., Plummer, Sue F., Marchesi, Julian R., Davidge, Kelly S. and Ludgate, Marian 2017. The microbiota and autoimmunity: their role in thyroid autoimmune diseases. Clinical Immunology 183 , pp. 63-74. 10.1016/j.clim.2017.07.001 |
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| Muller, I., Kilburn, L. S., Taylor, P. N., Barrett-Lee, P. J., Bliss, J. M., Ellis, P., Ludgate, M. E. and Dayan, C. M. 2017. TPOAb and thyroid function are not associated with breast cancer outcome: evidence from a large-scale study using data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). European Thyroid Journal 6 (4) , pp. 197-207. 10.1159/000460246 |
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| Covelli, D. and Ludgate, Marian Elizabeth 2017. The thyroid, the eyes and the gut: a possible connection. Journal of Endocrinological Investigation 40 (6) , pp. 567-576. 10.1007/s40618-016-0594-6 |
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| Covelli, Danila, Colucci, Giuseppe, Salvi, Mario, Kaiser, Ulrike, Eckstein, Anja, Burlacu, Maria Cristina, Daumerie, Chantal, Richell, Gez, Perros, Petros, Draman, Mohd, Ludgate, Marian Elizabeth, Masetti, Giulia and Biscarini, Filippo 2017. Immune reaction to food antigens in Graves' disease (GD) patients: role of gliadin and other food antigens. Presented at: 19th European Congress of Endocrinology 2017, Lisbon, Portugal, 20-23 May 2017. Endocrine Abstracts. Lisbon: EP1342. 10.1530/endoabs.49.EP1342 |
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Draman, Mohd Shazli, Stechman, Michael, Scott-Coombes, David, Dayan, Colin M., Rees, Dafydd Aled, Ludgate, Marian and Zhang, Lei
2017.
The role of thyrotropin receptor activation in adipogenesis and modulation of fat phenotype.
Frontiers in Endocrinology
8
, 83.
10.3389/fendo.2017.00083
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| Ruffino, J. S., Davies, N. A., Morris, K., Ludgate, Marian, Zhang, Lei, Webb, R. and Thomas, A. W. 2016. Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ. European Journal of Applied Physiology 116 (9) , pp. 1671-1682. 10.1007/s00421-016-3414-y |
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| Draman, Mohd Shazli and Ludgate, Marian 2016. Thyroid eye disease- an update. Expert Review of Ophthalmology 11 (4) , pp. 273-284. 10.1080/17469899.2016.1202113 |
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| Muller, Ilaria, Zhang, Lei, Giani, C, Dayan, Colin Mark, Ludgate, Marian Elizabeth and Grennan-Jones, F. 2016. The sodium iodide symporter is unlikely to be a thyroid/breast shared antigen. Journal of Endocrinological Investigation 39 (3) , pp. 323-331. 10.1007/s40618-015-0368-6 |
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| Connolly, Katherine D., Guschina, Irina A., Yeung, Vincent, Clayton, Aled, Shazli Draman, Mohd, Von Ruhland, Christopher, Ludgate, Marian Elizabeth, James, Philip E. and Rees, Dafydd Aled 2015. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis. Journal of Extracellular Vesicles 4 (s1) , 29159. 10.3402/jev.v4.29159 |
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| Perros, Petros, Dayan, Colin Mark, Dickinson, A. Jane, Ezra, Daniel G., Hickey, Janis L., Hintschisch, Christoph, Kahaly, George, Lazarus, John Henry, Ludgate, Marian Elizabeth, Bartès, Beate, MacEwen, Caroline J., Mitchell, Anna L., Morris, Dan, O'Connor, Nicole, Pearce, Simon H., Rose, Geoffrey E., Salvi, Mario, Wiersinga, Wilmar M. and Williamson, Alyson 2015. Future research in Graves' Orbitopathy: from priority setting to trial design through patient and public involvement. Thyroid: official journal of the American Thyroid Association 25 (11) , pp. 1181-1184. 10.1089/thy.2015.0222 |
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| Zhang, Lei, Ji, Q. H. J., Ruge, Fiona, Lane, C., Morris, D., Tee, Andrew, Dayan, Colin Mark and Ludgate, Marian Elizabeth 2015. Reversal of pathological features of Graves' orbitopathy by activation of forkhead transcription factors, FOXOs. Journal of Clinical Endocrinology & Metabolism 101 (1) , pp. 114-122. 10.1210/jc.2015-2932 |
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| Zhang, Lei, Grennan-Jones, Fiona, Draman, M.S., Lane, C., Morris, D., Dayan, Colin, Tee, Andrew and Ludgate, Marian Elizabeth 2014. Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy. Journal of Clinical Endocrinology & Metabolism 99 (7) , E1183-E1190. 10.1210/jc.2013-4182 |
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| Muller, I., Giani, C., Zhang, Lei, Grennan-Jones, F. A, Fiore, E., Belardi, V., Rosellini, V., Funel, N., Campani, D., Giustarini, E., Lewis, M. D., Bakhsh, A. D., Roncella, M., Ghilli, M., Vitti, P., Dayan, C. M. and Ludgate, M. E. 2014. Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer? International Journal of Cancer 134 (7) , pp. 1706-1714. 10.1002/ijc.28493 |
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| Hales, Charlotte, Channon, Susan, Taylor, Peter, Draman, Mohd, Muller, Ilaria, Lazarus, John Henry, Paradice, Ruth, Rees, Dafydd Aled, Shillabeer, Dionne, Gregory, John Welbourn, Dayan, Colin Mark and Ludgate, Marian Elizabeth 2014. The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol. BMC Endocrine Disorders 14 (1) , 95. 10.1186/1472-6823-14-95 |
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| Draman, Mohd, Grennan-Jones, Fiona, Zhang, Lei, Taylor, Peter, Tun, T., McDermott, J., Moriarty, P., Morris, D., Lane, C., Sreenan, S., Dayan, Colin and Ludgate, Marian Elizabeth 2013. Effects of Prostaglandin F2a on adipocyte biology relevant to graves' orbitopathy. Thyroid: official journal of the American Thyroid Association 23 (12) , pp. 1600-1608. 10.1089/thy.2013.0194 |
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| Zhang, Lei and Ludgate, Marian E. 2012. The search for biomarkers of disease: surface-enhanced laser desorption/ionization time-of-flight mass spectrometry, tears, and thyroid-associated ophthalmopathy. Thyroid: official journal of the American Thyroid Association 22 (10) , pp. 981-983. 10.1089/thy.2012.2210.ed2 |
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| Bullock, Martyn, Duncan, Emma L., O'Neill, Christine, Tacon, Lyndal, Sywak, Mark, Sidhu, Stan, Delbridge, Leigh, Learoyd, Diana, Robinson, Bruce G., Ludgate, Marian Elizabeth and Clifton-Bligh, Roderick J. 2012. Association of FOXE1 polyalanine repeat region with papillary thyroid cancer. Journal of Clinical Endocrinology & Metabolism 97 (9) , E1814-E1819. 10.1210/jc.2012-1456 |
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| Zhang, Lei, Grennan-Jones, Fiona Antoinette, Lane, Carol, Rees, Dafydd Aled, Dayan, Colin Mark and Ludgate, Marian Elizabeth 2012. Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy. Journal of Clinical Endocrinology & Metabolism 97 (2) , pp. 653-662. 10.1210/jc.2011-1299 |
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| Krause, Kerstin, Boisnard, Alexandra, Ihling, Christian, Ludgate, Marian Elizabeth, Eszlinger, Markus, Krohn, Knut, Sinz, Andrea and Fuhrer, Dagmar 2012. Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid. International Journal of Biochemistry & Cell Biology 44 (2) , pp. 290-301. 10.1016/j.biocel.2011.10.024 |
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| Lansdown, Andrew John, Ludgate, Marian Elizabeth and Rees, Dafydd Aled 2012. Metabolic syndrome: is the preadipocyte to blame? [Commentary]. Clinical Endocrinology 76 (1) , pp. 19-20. 10.1111/j.1365-2265.2011.04176.x |
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| Ludgate, Marian Elizabeth 2011. Extrathyroidal thyroid hormone synthesis? Journal of Endocrinology 210 (1) , pp. 3-4. 10.1530/JOE-11-0159 |
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| Müller, Kathrin, Krohn, Knut, Eszlinger, Markus, Ludgate, Marian Elizabeth and Führer, Dagmar 2011. Effect of iodine on early stage thyroid autonomy. Genomics 97 (2) , pp. 94-100. 10.1016/j.ygeno.2010.10.007 |
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| Stephens, Mark William, Ludgate, Marian Elizabeth and Rees, Dafydd Aled 2011. Brown fat and obesity: the next big thing? Clinical Endocrinology 74 (6) , pp. 661-670. 10.1111/j.1365-2265.2011.04018.x |
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| Agarwal, Neera, Rice, Sam P. L., Bolusani, Hemanth, Luzio, Stephen Denis, Dunseath, Gareth John, Ludgate, Marian Elizabeth and Rees, Dafydd Aled 2010. Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: A randomized, placebo-controlled, crossover trial. Obstetrical & Gynecological Survey 65 (6) , pp. 381-382. 10.1097/OGX.0b013e3181e5a167 |
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| Rice, Samuel Peter Llewellyn, Zhang, Lei, Grennan-Jones, Fiona Antoinette, Agarwal, Neera, Lewis, Mark David, Rees, Dafydd Aled and Ludgate, Marian Elizabeth 2010. Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue. Molecular and Cellular Endocrinology 320 (1-2) , pp. 51-57. 10.1016/j.mce.2010.02.017 |
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| De Lloyd, Anna Claire, Bursell, James D. H., Gregory, John Welbourn, Rees, Dafydd Aled and Ludgate, Marian Elizabeth 2010. TSH receptor activation and body composition. Journal of Endocrinology 204 (1) , pp. 13-20. 10.1677/JOE-09-0262 |
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| Agarwal, Neera, Rice, Sam P. L., Bolusani, Hemanth, Luzio, Stephen D., Dunseath, Gareth, Ludgate, Marian and Rees, D. Aled 2010. Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled, Crossover Trial. Journal of Clinical Endocrinology & Metabolism 95 (2) , pp. 722-730. 10.1210/jc.2009-1985 |
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| Ludgate, Marian Elizabeth 2010. Animal models of Graves' disease [Abstract]. Endocrine Journal -Tokyo- 57 (S2) , p. 237. 10.1507/endocrj.57.S213 |
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| Zhang, Lei, Bowen, Timothy, Grennan-Jones, Fiona Antoinette, Paddon, Carol Ann, Giles, Peter James, Webber, Jason P., Steadman, Robert and Ludgate, Marian Elizabeth 2009. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction. Journal of Biological Chemistry 284 (39) , pp. 26447-26455. 10.1074/jbc.M109.003616 |
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| Zhang, Lei, Paddon, Carol Ann, Lewis, Mark David, Grennan-Jones, Fiona Antoinette and Ludgate, Marian Elizabeth 2009. Gsα signalling suppresses PPARγ2 generation and inhibits 3T3L1 adipogenesis. Journal of Endocrinology 202 (2) , pp. 207-215. 10.1677/JOE-09-0099 |
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| Rice, Sam P. L., Agarwal, Neera, Bolusani, Hemanth, Newcombe, Robert Gordon, Scanlon, Maurice Francis, Ludgate, Marian Elizabeth and Rees, Dafydd Aled 2009. Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: A randomized crossover trial. Journal of Clinical Endocrinology & Metabolism 94 (6) , pp. 1966-1972. 10.1210/jc.2008-2636 |
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| Premawardhana, Lakdassa D. K. E. and Ludgate, Marian Elizabeth 2009. John Lazarus. Endocrine Practice 15 (1) , pp. 48-49. |
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| Eckstein, A. K., Johnson, K. T. M., Thanos, M., Esser, J. and Ludgate, Marian Elizabeth 2009. Current insights into the pathogenesis of Graves' orbitopathy. Hormone and Metabolic Research 41 (6) , pp. 456-464. 10.1055/s-0029-1220935 |
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| Cozma, Ingrid Daniela, Cozma, L. S., Boyce, R. L., Ludgate, Marian Elizabeth, Lazarus, John Henry and Lane, C. M. 2009. Variation in thyroid status in patients with Graves' orbitopathy. Acta Endocrinologica (Bucharest) 5 (2) , pp. 191-198. 10.4183/aeb.2009.191 |
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| Fuhrer, Dagmar, Han, Song and Ludgate, Marian Elizabeth 2008. Enhancement of Glycoprotein Hormone Alpha Subunit Promoter Reporter Gene Activity in Co-transfection Studies - A Cautionary Reminder. Hormone and Metabolic Research 40 (11) , pp. 787-793. 10.1055/s-2008-1078717 |
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| Ludgate, Marian Elizabeth and Emerson, Charles H. 2008. Metamorphic thyroid autoimmunity [Editorial]. Thyroid: official journal of the American Thyroid Association 18 (10) , pp. 1035-1037. 10.1089/thy.2008.1551 |
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| Cozma, Irina, Zhang, Lei, Uddin, James, Lane, Carol, Rees, Dafydd Aled and Ludgate, Marian Elizabeth 2007. Modulation of expression of somatostatin receptor subtypes in Graves' opthalmopathy orbits : relevance to novel analogues. American Journal of Physiology. Endocrinology and Metabolism 10.1152/ajpendo.00177.2007 |
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| Zhang, Lei, Baker, Glynn, Janus, Dominika, Paddon, Carol A., Fuhrer, Dagmar and Ludgate, Marian 2006. Biological effects of thyrotropin receptor activation on human orbital dreadipocytes. Investigative Ophthalmology & Visual Science 47 (12) , pp. 5197-5203. 10.1167/iovs.06-0596 |
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| Baker, G. R. C., Morton, M., Rajapaska, R. S., Bullock, M., Gullu, S., Mazzi, B. and Ludgate, Marian Elizabeth 2006. Altered Tear Composition in Smokers and Patients With Graves Ophthalmopathy. Archives of Ophthalmology 124 (10) , pp. 1451-1456. 10.1001/archopht.124.10.1451 |
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| Bakhsh, Ameen, Kirov, George, Gregory, John Welbourn, Williams, E. D. and Ludgate, Marian Elizabeth 2006. A new form of familial multi-nodular goitre with progression to differentiated thyroid cancer. Endocrine-Related Cancer 13 (2) , pp. 475-483. 10.1677/erc.1.01138 |
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| Baker, Glynn Raymond, Mazziotti, Gherardo, Von Ruhland, Christopher John and Ludgate, Marian Elizabeth 2005. Reevaluating thyrotropin receptor-induced mouse models of Graves' disease and ophthalmopathy. Endocrinology 146 (2) , pp. 835-844. 10.1210/en.2004-1015 |
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| Evans, Carol, Jordan, Nicola, Owens, G., Bradley, D., Ludgate, Marian Elizabeth and John, R. 2004. Potent thyrotrophin receptor-blocking antibodies: a cause of transient congenital hypothyroidism and delayed thyroid development. European Journal of Endocrinology 150 (3) , pp. 265-268. 10.1530/eje.0.1500265 |
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| Fuhrer, D., Lewis, Mark David, Alkhafaji, F., Starkey, K., Paschke, R., Wynford-Thomas, David, Eggo, M. and Ludgate, Marian Elizabeth 2003. Biological activity of activating thyroid-stimulating hormone receptor mutants depends on the cellular context. Endocrinology 144 (9) , pp. 4018-4030. 10.1210/en.2003-0438 |
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| Jordan, Nicola, Williams, Nigel Melville, Gregory, John Welbourn, Evans, C., Owen, Michael John and Ludgate, Marian Elizabeth 2003. The W546X mutation of the thyrotropin receptor gene: potential major contributor to thyroid dysfunction in a Caucasian population. Journal of Clinical Endocrinology & Metabolism 88 (3) , pp. 1002-5. 10.1210/jc.2002-021301 |
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| Starkey, Kerry, Heufelder, Armin, Baker, Glynn Raymond, Joba, Wener, Evans, Marc, Davies, Stephen and Ludgate, Marian Elizabeth 2003. Peroxisome proliferator-activated receptor-gamma in thyroid eye disease: contraindication for thiazolidinedione use? Journal of Clinical Endocrinology & Metabolism 88 (1) , pp. 55-59. 10.1210/jc.2002-020987 |
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| Fuhrer, D., Gregory, John Welbourn and Ludgate, Marian Elizabeth 2002. Re: "An activating mutation of the thyrotropin receptor gene in hereditary non-autoimmune hyperthyroidism" by Yung-Seng Lee et al. J Pediatr Endocrinol Metab 2002; 15: 211-215. Journal of Pediatric Endocrinology & Metabolism 15 (9) , p. 1569. |
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| Jordan, Nicola, Rinderle, C., Ashfield, J., Morgenthaler, N. G., Lazarus, John Henry, Ludgate, Marian Elizabeth and Evans, C. 2001. A luminescent bioassay for thyroid blocking antibodies. Clinical Endocrinology 54 (3) , pp. 355-364. 10.1046/j.1365-2265.2001.01193.x |
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| Fuhrer, D., Warner, J., Sequeira, R., Paschke, R., Gregory, John Welbourn and Ludgate, Marian Elizabeth 2000. Novel TSHR germline mutation (Met463Val) masquerading as Graves' disease in a large Welsh kindred with hyperthyroidism. Thyroid: Official Journal of the American Thyroid Association 10 (12) , pp. 1035-1041. 10.1089/thy.2000.10.1035 |
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| Evans, C., Morgenthaler, N. G., Lee, S., Llewellyn, David H., Clifton-Bligh, R., John, Robert Anthony, Lazarus, John Henry, Chatterjee, V. K. K. and Ludgate, Marian Elizabeth 1999. Development of a Luminescent Bioassay for Thyroid Stimulating Antibodies. Journal of Clinical Endocrinology & Metabolism 84 (1) , pp. 374-377. 10.1210/jc.84.1.374 |
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