Edmans, Matthew, McNee, Adam, Porter, Emily, Vatzia, Eleni, Paudyal, Basu, Martini, Veronica, Gubbins, Simon, Francis, Ore, Harley, Ross, Thomas, Amy, Burt, Rachel, Morgan, Sophie, Fuller, Anna, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Charleston, Bryan, Bailey, Mick and Tchilian, Elma 2021. Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in inbred Babraham pigs and outbred pigs. Frontiers in Immunology 11 , 604913. 10.3389/fimmu.2020.604913 |
Crowther, Michael D., Dolton, Garry, Legut, Mateusz, Caillaud, Marine E., Lloyd, Angharad, Attaf, Meriem, Galloway, Sarah A. E., Rius, Cristina, Farrell, Colin P., Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761, Fuller, Anna, Donia, Marco, McCluskey, James, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Svane, Inge Marie, Phillips, John D. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21 , 178 - 185. 10.1038/s41590-019-0578-8 |
Whalley, Thomas, Dolton, Garry, Brown, Paul E., Wall, Aaron, Wooldridge, Linda, van den Berg, Hugo, Fuller, Anna, Hopkins, Jade R., Crowther, Michael D., Attaf, Meriem, Knight, Robin R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11 , 296. 10.3389/fimmu.2020.00296 |
Madura, Florian, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49 (7) , pp. 1052-1066. 10.1002/eji.201948085 |
Galloway, Sarah A. E., Dolton, Garry, Attaf, Meriem, Wall, Aaron, Fuller, Anna, Rius, Cristina, Bianchi, Valentina, Theaker, Sarah, Lloyd, Angharad, Caillaud, Marine E., Svane, Inge Marie, Donia, Marco, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10 , 319. 10.3389/fimmu.2019.00319 |
Dolton, Garry, Zervoudi, Efthalia, Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Wall, Aaron, Thomas, Hannah L., Fuller, Anna, Yeo, Lorraine, Legut, Mateusz, Wheeler, Sophie, Attaf, Meriem, Chudakov, Dmitriy M., Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Peakman, Mark and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9 , 1378. 10.3389/fimmu.2018.01378 |
Tungatt, Katie, Dolton, Garry, Morgan, Sophie B., Attaf, Meriem, Fuller, Anna, Whalley, Thomas, Hemmink, Johanneke D., Porter, Emily, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Montoya, Maria, Hammond, John A., Miles, John J., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Townsend, Alain, Bailey, Mick, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Charleston, Bryan, Tchilian, Elma and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14 (5) , e1007017. 10.1371/journal.ppat.1007017 |
Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wells, Stephen and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9 , 674. 10.3389/fimmu.2018.00674 |
Bovay, Amandine, Zoete, Vincent, Dolton, Garry, Bulek, Anna M., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Fuller, Anna, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Michielin, Olivier, Speiser, Daniel E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Fuertes Marraco, Silvia A. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48 (2) , pp. 258-272. 10.1002/eji.201747082 |
Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J., Bulek, Anna M., Bridgeman, John S., Miles, John J., Schauenburg, Andrea J. A., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Evavold, Brian D., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8 , 1503. 10.3389/fimmu.2017.01503 |
Trueman, Rebecca C., Diaz, Claris, Farr, Tracy D., Harrison, David J., Fuller, Anna, Tokarczuk, Pawel F., Stewart, Andrew J., Paisey, Stephen J. ORCID: https://orcid.org/0000-0002-2274-3708 and Dunnett, Stephen B. ORCID: https://orcid.org/0000-0003-1826-1578 2017. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: tests for long-term assessment. Journal of Cerebral Blood Flow and Metabolism 37 (4) , pp. 1349-1361. 10.1177/0271678X16654921 |
MacLachlan, Bruce J., Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea J., Bianchi, Valentina, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Fuller, Anna and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments (120) , e54991. 10.3791/54991 |
Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, van den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna M., Dolton, Garry, Schauenburg, Andrea J., Wall, Aaron, Fuller, Anna, Clement, Mathew, Laugel, Bruno, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292 (3) , pp. 802-813. 10.1074/jbc.M116.741603 |
Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Bulek, Anna M., Dolton, Garry, Schauenberg, Andrea J., Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Zhu, Cheng, Miles, John J., Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126 (6) , pp. 2191-2204. 10.1172/JCI85679 |
Bianchi, Valentina, Bulek, Anna, Fuller, Anna, Lloyd, Angharad, Attaf, Meriem, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Dolton, Garry, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291 (17) , pp. 8951-8959. 10.1074/jbc.M115.707414 |
Theaker, Sarah M., Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew R., Fuller, Anna, Miles, John James, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Dolton, Garry Michael 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430 , pp. 43-50. 10.1016/j.jim.2016.01.014 |
Madura, Florian, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Holland, Christopher J., Fuller, Anna, Bulek, Anna Marta, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Schauenburg, Andrea J., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45 (2) , pp. 584-591. 10.1002/eji.201445114 |
Kløverpris, Henrik N., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Fuller, Anna, Carlson, Jonathan, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Schauenburg, Andrea J. A., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Buus, Søren, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Goulder, Philip 2015. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12 (1) , 20. 10.1186/s12977-015-0149-5 |
Motozono, Chihiro, Kuse, N, Sun, X., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Fuller, Anna, Oka, S., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Takiguchi, M. 2014. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. The Journal of Immunology 192 (7) , pp. 3428-3434. 10.4049/jimmunol.1302667 |
Madura, Florian, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Miles, Kim Michelle, Holland, Christopher J., Bulek, Anna Marta, Fuller, Anna, Schauenburg, Andrea J. A., Miles, John James, Liddy, Nathaniel, Sami, M., Li, Y., Hossain, M., Baker, B. M., Jakobsen, B. K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2013. T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry 288 (26) , pp. 18766-18775. 10.1074/jbc.M113.464560 |
Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Miles, Kim Michelle, Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Bulek, Anna Marta, Fuller, Anna, Akpovwa, Hephzibah, Pymm, Phillip G., Liddy, N., Sami, M., Li, Y., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Jakobsen, B. K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289 (2) , pp. 628-638. 10.1074/jbc.M113.522110 |
Ekeruche, Julia, Clement, Mathew, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John James, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry Michael, Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409 |
Ekeruche-Makinde, Julia, Clement, Mathew, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409 |
Holland, Christopher J., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Stern, Lawrence J., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2 , 629. 10.1038/srep00629 |
Bulek, Anna Marta, Madura, Florian, Fuller, Anna, Holland, Christopher J., Schauenburg, Andrea J. A., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2012. TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods 382 (1-2) , pp. 203-210. 10.1016/j.jim.2012.06.007 |
Bulek, Anna Marta, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Skowera, Ania, Dolton, Garry Michael, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John James, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206 |