Browse by Current Cardiff authors

Kandil, Sahar B., Kariuki, Benson M., McGuigan, Christopher and Westwell, Andrew D. 2021. Synthesis, biological evaluation and X-ray analysis of bicalutamide sulfoxide analogues for the potential treatment of prostate cancer. Bioorganic and Medicinal Chemistry Letters 36 , 127817. 10.1016/j.bmcl.2021.127817 Item availability restricted.

Kourti, Malamati, Cai, Jun, Jiang, Wen and Westwell, Andrew D. 2021. Structural modifications on CORM-3 lead to enhanced anti-angiogenic properties against triple-negative breast cancer cells. Medicinal Chemistry 17 (1) , pp. 40-59. 10.2174/1573406415666191206102452

Kandil, Sahar B., McGuigan, Christopher and Westwell, Andrew D. 2021. Synthesis and biological evaluation of bicalutamide analogues for the potential treatment of prostate cancer. Molecules 26 (1) , 56. 10.3390/molecules26010056

Hamdy, Rania, Elseginy, Samia A., Ziedan, Noha I., El-Sadek, Mohamed, Lashin, Elsaid, Jones, Arwyn T. and Westwell, Andrew D. 2020. Design, synthesis and evaluation of new bioactive oxadiazole derivatives as anticancer agents targeting Bcl-2. International Journal of Molecular Sciences 21 (23) , 8980. 10.3390/ijms21238980

Kandil, Sahar B., Jones, Samuel R., Smith, Sonia, Hiscox, Stephen E. and Westwell, Andrew D. 2020. Structure-based virtual screening, synthesis and biological evaluation of potential FAK-FAT domain inhibitors for treatment of metastatic cancer. Molecules 25 (15) , 3488. 10.3390/molecules25153488

Cavaliere, Alessandra, Probst, Katrin C., Paisey, Stephen J., Marshall, Christopher, Dheere, Abdul K. H., Aigbirhio, Franklin, McGuigan, Christopher and Westwell, Andrew D. 2020. Radiosynthesis of [18F]-labelled pro-nucleotides (ProTides). Molecules 25 (3) , 704. 10.3390/molecules25030704

Kandil, Sahar, Pannecouque, Christophe, Chapman, Fiona M., Westwell, Andrew D. and McGuigan, Christopher 2019. Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity. Bioorganic and Medicinal Chemistry Letters 29 (24) , 126721. 10.1016/j.bmcl.2019.126721

Pertusati, Fabrizio, Ferla, Salvatore, Bassetto, Marcella, Brancale, Andrea, Kandil, Sahar, Westwell, Andrew D. and McGuigan, Christopher 2019. A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer. European Journal of Medicinal Chemistry 180 , pp. 1-14. 10.1016/j.ejmech.2019.07.001

Crusco, Alessandra, Whiteland, Helen, Baptista, Rafael, Forde-Thomas, Josephine E., Beckmann, Manfred, Mur, Luis A. J., Nash, Robert J., Westwell, Andrew D. and Hoffmann, Karl F. 2019. Antischistosomal properties of sclareol and its heck-coupled derivatives: Design, synthesis, biological evaluation, and untargeted metabolomics. ACS Infectious Diseases 5 (7) , pp. 1188-1199. 10.1021/acsinfecdis.9b00034

Crusco, Alessandra, Baptista, Rafael, Bhowmick, Sumana, Beckmann, Manfred, Mur, Luis A. J., Westwell, Andrew D. and Hoffmann, Karl F. 2019. The anti-mycobacterial activity of a diterpenoid-like molecule operates through nitrogen and amino acid starvation. Frontiers in Microbiology 10 , 1444. 10.3389/fmicb.2019.01444

Hamdy, Rania, Elseginy, Samia, Ziedan, Noha, Jones, Arwyn and Westwell, Andrew 2019. New quinoline-based heterocycles as anticancer agents targeting Bcl-2. Molecules 24 (7) , p. 1274. 10.3390/molecules24071274

Kandil, Sahar, Lee, Kok Yung, Davies, Laurie, Rizzo, Sebastiano A., Dart, D. Alwyn and Westwell, Andrew D. 2019. Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists. European Journal of Medicinal Chemistry 167 , pp. 49-60. 10.1016/j.ejmech.2019.01.054

Anderson, Robin L., Balasas, Theo, Callaghan, Juliana, Coombes, R. Charles, Evans, Jeff, Hall, Jacqueline A., Kinrade, Sally, Jones, David, Jones, Paul S., Jones, Rob, Marshall, John F., Panico, Maria Beatrice, Shaw, Jacqui A., Steeg, Patricia S., Sullivan, Mark, Tong, Warwick, Westwell, Andrew D. and Ritchie, James W. A. 2019. A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology 16 , pp. 185-204. 10.1038/s41571-018-0134-8

James, Edward, Robertshaw, Thomas L and Westwell, Andrew D 2019. Emerging from the dark side: new therapeutic applications of scheduled psychoactive substances. Future Medicinal Chemistry 11 (3) 10.4155/fmc-2018-0447

Fosu-Mensah, Nelly A., Jiang, Wen, Brancale, Andrea, Cai, Jun and Westwell, Andrew D. 2019. The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein-protein interaction. Medicinal Chemistry Research 28 (2) , pp. 182-202. 10.1007/s00044-018-2275-9

Kourti, Malamati, Westwell, Andrew, Jiang, Wen and Cai, Jun 2019. Repurposing old carbon monoxide-releasing molecules towards the anti-angiogenic therapy of triple-negative breast cancer. Oncotarget 10 (10) , pp. 1132-1148. 10.18632/oncotarget.26638

James, Edward, Robertshaw, Thomas, Chapman, Fiona M., Westwell, Andrew D. and Smith, Andrew P. 2019. Using the pharmacy retail model to examine perceptions and biases of a UK population sample towards regulation of specific psychoactive drugs. Drug Science, Policy and Law 5 10.1177/2050324519876123

Shirinzadeh, Hanif, Suzen, Sibel, Altanlar, Nurten and Westwell, Andrew 2018. Antimicrobial activities of new indole derivatives containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide. The Turkish Journal of Pharmaceutical Sciences 15 (3) , pp. 291-297. 10.4274/tjps.55707

Dart, D. Alwyn, Kandil, Sahar, Tommasini-Ghelfi, Serena, Almeida, Gilberto Serrano de, Bevan, Charlotte L., Jiang, Wen Guo and Westwell, Andrew D. 2018. Novel trifluoromethylated enobosarm analogues with potent antiandrogenic activity in vitro and tissue selectivity in vivo. Molecular Cancer Therapeutics 17 (9) , pp. 1846-1858. 10.1158/1535-7163.MCT-18-0037

Crusco, Alessandra, Bordoni, Cinzia, Chakroborty, Anand, Whatley, Kezia C.L., Whiteland, Helen, Westwell, Andrew D. and Hoffmann, Karl F. 2018. Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues. European Journal of Medicinal Chemistry 152 , pp. 87-100. 10.1016/j.ejmech.2018.04.032

James, Edward, Robertshaw, Thomas, Westwell, Andrew and Smith, Andrew 2018. Pharmacies as potential providers of harm reduction services: A preliminary online survey. Drug Science, Policy and Law 4 , pp. 1-14. 10.1177/2050324518767441

Kandil, Sahar, Prencipe, Filippo, Jones, Samuel, Hiscox, Stephen and Westwell, Andrew D. 2018. The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer. Chemical Biology and Drug Design 91 (1) , pp. 314-321. 10.1111/cbdd.13083

Somasagara, R. R., Spencer, S. M., Tripathi, K., Clark, D. W., Mani, C., Madeira da Silva, L., Scalici, J., Kothayer, H., Westwell, A. D., Rocconi, R. P. and Palle, K. 2017. RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance. Oncogene 36 , pp. 6680-6690. 10.1038/onc.2017.279

Cavaliere, Alessandra, Probst, Katrin, Westwell, Andrew and Slusarczyk, Magdalena 2017. Fluorinated nucleosides as an important class of anticancer and antiviral agents. Future Medicinal Chemistry 9 (15)

Hendriks, Hans R, Govaerts, Anne-Sophie, Fichtner, Iduna, Burtles, Sally, Westwell, Andrew and Peters, Godefridus J 2017. Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative. British Journal of Cancer 117 , pp. 195-202. 10.1038/bjc.2017.167

Bassetto, Marcella, Ferla, Salvatore, Giancotti, Gilda, Pertusati, Fabrizio, Westwell, Andrew D., Brancale, Andrea and McGuigan, Christopher 2017. Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents. MedChemComm 8 (7) , pp. 1414-1420. 10.1039/C7MD00164A

Hamdy, Rania, Ziedan, Noha, Ali, Samina, Bordoni, Cinzia, El-Sadek, Mohamed, Lashin, Elsaid, Brancale, Andrea, Jones, Arwyn Tomos and Westwell, Andrew D 2017. Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. Bioorganic & Medicinal Chemistry Letters 27 (4) , pp. 1037-1040. 10.1016/j.bmcl.2016.12.061

Ziedan, Noha I, Hamdy, Rania, Cavaliere, Alessandra, Kourti, Malamati, Prencipe, Filippo, Brancale, Andrea, Jones, Arwyn T and Westwell, Andrew 2017. Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor. Chemical Biology and Drug Design 10.1111/cbdd.12936

Wymant, Jennifer, Hiscox, Stephen, Westwell, Andrew, Urbe, Sylvie, Clague, Michael and Jones, Arwyn Tomos 2016. The Role of BCA2 in the endocytic trafficking of EGFR and significance as a prognostic biomarker in cancer. Journal of Cancer 7 (15) , pp. 2388-2407. 10.7150/jca.15055

Kandil, Sahar, Balzarini, Jan, Rat, Stephanie, Brancale, Andrea, Westwell, Andrew D. and McGuigan, Christopher 2016. ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites. Biorganic and Medicinal Chemistry Letters 26 (23) , pp. 5618-5623. 10.1016/j.bmcl.2016.10.077

Bassetto, Marcella, Ferla, Salvatore, Pertusati, Fabrizio, Kandil, Sahar, Westwell, Andrew, Brancale, Andrea and McGuigan, Christopher 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118 , pp. 230-243. 10.1016/j.ejmech.2016.04.052

Ferla, Salvatore, Bassetto, Marcella, Pertusati, Fabrizio, Kandil, Sahar, Westwell, Andrew D., Brancale, Andrea and McGuigan, Christopher 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic and Medicinal Chemistry Letters 26 (15) , pp. 3636-3640. 10.1016/j.bmcl.2016.06.001

Haynes, Brittany, Zhang, Yanhua, Liu, Fangchao, Li, Jing, Petit, Sarah, Kothayer, Hend, Bao, Xun, Westwell, Andrew D., Mao, Guangzhao and Shekhar, Malathy P.V. 2016. Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization. Nanomedicine: Nanotechnology, Biology and Medicine 12 (3) , pp. 745-757. 10.1016/j.nano.2015.10.010

Kothayer, Hend, Spencer, Sebastian M., Tripathi, Kaushlendra, Westwell, Andrew D. and Palle, Komaraiah 2016. Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors. Biorganic and Medicinal Chemistry Letters 26 (8) , pp. 2030-2034. 10.1016/j.bmcl.2016.02.085

Kandil, Sahar, Wymant, Jennifer, Kariuki, Benson, Jones, Arwyn Tomos, McGuigan, Christopher and Westwell, Andrew David 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110 , pp. 311-325. 10.1016/j.ejmech.2015.12.037

Kandil, Sahar, Westwell, Andrew D. and McGuigan, Christopher 2016. 7-Substituted umbelliferone derivatives as androgen receptor antagonists for the potential treatment of prostate and breast cancer. Biorganic and Medicinal Chemistry Letters 26 (8) , pp. 2000-2004. 10.1016/j.bmcl.2016.02.088

Westwell, Andrew David, ed. 2016. Fluorinated pharmaceuticals: advances in medicinal chemistry. Future Medicine. 10.4155/9781909453968

Shirinzadeh, Hanif, Ince, Elif, Westwell, Andrew David, Gurer-Orhan, Hande and Suzen, Sibel 2016. Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities. Journal of Enzyme Inhibition and Medicinal Chemistry 31 (6) , pp. 1312-1321. 10.3109/14756366.2015.1132209

Edwards, Richard, de Vries, Wilke, Westwell, Andrew D., Daniels, Stephen and Wirth, Thomas 2015. Solid-supported iodonium salts for fluorinations. European Journal of Organic Chemistry 2015 (31) , pp. 6909-6916. 10.1002/ejoc.201500992

Cilibrasi, Vincenzo, Tsang, Kwok Ying Ingrid, Morelli, Matteo, Solfa, Francesca, Wiggins, Helen, Jones, Arwyn Tomos and Westwell, Andrew David 2015. Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. Tetrahedron Letters 56 (20) , pp. 2583-2585. 10.1016/j.tetlet.2015.03.132

Wiggins, Helen L., Wymant, Jennifer M., Solfa, Francesca, Hiscox, Stephen E., Taylor, Kathryn M., Westwell, Andrew D. and Jones, Arwyn T. 2015. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology 93 (3) , pp. 332-342. 10.1016/j.bcp.2014.12.014

Edwards, Richard, Westwell, Andrew D., Daniels, Stephen and Wirth, Thomas 2015. Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA. European Journal of Organic Chemistry 2015 (3) , pp. 625-630. 10.1002/ejoc.201403378

Fosu-Mensah, Nelly, Peris, María Sánchez, Weeks, Hoi Ping, Cai, Jun and Westwell, Andrew David 2015. Advances in small-molecule drug discovery for triple-negative breast cancer. Future Medicinal Chemistry 7 (15) , pp. 2019-2039. 10.4155/fmc.15.129

Meyer, Jan-Philip, Probst, Katrin C., Trist, Iuni Margaret, McGuigan, Christopher and Westwell, Andrew David 2014. A novel radiochemical approach to 1-(2 '-deoxy-2 '-[F-18] fluoro-beta-D-arabinofuranosyl)cytosine (F-18-FAC). Journal of Labelled Compounds and Radiopharmaceuticals 57 (11) , pp. 637-644. 10.1002/jlcr.3233

Meyer, Jan-Philip, Probst, Katrin C. and Westwell, Andrew D. 2014. Radiochemical synthesis of 2′-[18F]-labelled and 3′-[18F]-labelled nucleosides for positron emission tomography imaging. Journal of Labelled Compounds and Radiopharmaceuticals 57 (5) , pp. 333-337. 10.1002/jlcr.3197

Velanguparackel, Winnie, Hamon, Nadege, Balzarini, Jan, McGuigan, Christopher and Westwell, Andrew D. 2014. Synthesis, anti-HIV and cytostatic evaluation of 3′-deoxy-3′-fluorothymidine (FLT) pro-nucleotides. Bioorganic and Medicinal Chemistry Letters 24 (10) , pp. 2240-2243. 10.1016/j.bmcl.2014.03.092

Kothayer, Hend, Elshanawani, Abdalla A., Abu Kull, Mansour E., El-Sabbagh, Osama I., Shekhar, Malathy P. V., Brancale, Andrea, Jones, Arwyn Tomos and Westwell, Andrew D. 2013. Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. Biorganic and Medicinal Chemistry Letters 23 (24) , pp. 6886-6889. 10.1016/j.bmcl.2013.09.087

Hamdy, Rania, Ziedan, Noha, Ali, Samia, El-Sadek, Mohamed, Lashin, Elsaid, Brancale, Andrea, Jones, Arwyn Tomos and Westwell, Andrew D. 2013. Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. Biorganic and Medicinal Chemistry Letters 23 (8) , pp. 2391-2394. 10.1016/j.bmcl.2013.02.029

Sanders, Matthew A., Brahemi, Ghali, Nangia-Makker, Pratima, Balan, Vitaly, Morelli, Matteo, Kothayer, Hend, Westwell, Andrew D. and Shekhar, Malathy P. V. 2013. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: Design, synthesis, identification, and functional characterization. Molecular Cancer Therapeutics 12 (4) , pp. 373-383. 10.1158/1535-7163.MCT-12-0793

Tekiner-Gulbas, Betul, Westwell, Andrew D. and Suzen, Sibel 2013. Oxidative stress in carcinogenesis: new synthetic compounds with dual effects upon free radicals and cancer. Current Medicinal Chemistry 20 (36) , pp. 4451-4459. 10.2174/09298673113203690142

Weekes, Ashley Ann, Frydrych, Jan and Westwell, Andrew D. 2013. Convenient synthesis of substituted 2-phenylbenzothiazoles using solid-supported triphenylphosphine. Synthetic Communications 43 (19) , pp. 2656-2662. 10.1080/00397911.2012.730648

Karaaslan, Cigdem, Kadri, Hachemi, Coban, Tulay, Suzen, Sibel and Westwell, Andrew D. 2013. Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles. Biorganic and Medicinal Chemistry Letters 23 (9) , pp. 2671-2674. 10.1016/j.bmcl.2013.02.090

Westwell, Andrew D., Hutchings, Alun and Caldicott, D. G. E. 2013. The identification and chemical characterization of a new arylcyclohexylamine, methoxetamine, using a novel Emergency Department toxicosurveillance tool. Drug Testing and Analysis 5 (3) , pp. 203-207. 10.1002/dta.1375

Soukupova, J., Brancale, Andrea, Westwell, Andrew D. and Clarkson, Richard W. E. 2012. Inhibitors of Bcl-3 as a novel therapeutic strategy for HER2+ breast cancer. European Journal of Cancer 48 (5) , S225-S225.

Md Tohid, Siti Farah, Ziedan, Noha Ibrahim, Stefanelli, Fabio, Fogli, Stefano and Westwell, Andrew D. 2012. Synthesis and evaluation of indole-containing 3,5-diarylisoxazoles as potential pro-apoptotic antitumour agents. European Journal of Medicinal Chemistry 56 , pp. 263-270. 10.1016/j.ejmech.2012.08.009

Cottens, Sylvain, Eaton, Mike, Fuhr, Joseph, Geary, Steward, Johnson, Douglas S., Li, Ge, Raveglia, Luca, Robertson, Graeme M. and Westwell, Andrew D. 2011. Ask the experts: future of the pharmaceutical industry. Future Medicinal Chemistry 3 (15) 10.4155/fmc.11.145

Altug, C., Burnett, Alan Kenneth, Caner, E., Dürüst, Y., Elliott, Mark Christopher, Glanville, Roger P. J., Guy, Carol and Westwell, Andrew D. 2011. An efficient one-pot multicomponent approach to 5-amino-7-aryl-8-nitrothiazolo[3,2-a]pyridines. Tetrahedron 67 (49) , pp. 9522-9528. 10.1016/j.tet.2011.10.005

Weekes, Ashley Ann, Bagley, Mark Christopher and Westwell, Andrew D. 2011. An efficient synthetic route to biologically relevant 2-phenylbenzothiazoles substituted on the benzothiazole ring. Tetrahedron 67 (40) , pp. 7743-7747. 10.1016/j.tet.2011.08.004

Ziedan, Noha I., Stefanelli, Fabio, Fogli, Stefano and Westwell, Andrew D. 2010. Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles. European Journal of Medicinal Chemistry 45 (10) , pp. 4523-4530. 10.1016/j.ejmech.2010.07.012

Brahemi, Ghali, Kona, Fathima R., Fiasella, Annal, Buac, Daniela, Soukupova, Jitka, Brancale, Andrea, Burger, Angelika M. and Westwell, Andrew D. 2010. Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer. Journal of Medicinal Chemistry 53 (7) , pp. 2757-2765. 10.1021/jm901757t

Chew, Eng-Hui, Nagle, Amrita A., Zhang, Yaochun, Scarmagnani, Silvia, Palaniappan, Puvithira, Bradshaw, Tracey D., Holmgren, Arne and Westwell, Andrew D. 2010. Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. Free Radical Biology & Medicine 48 (1) , pp. 98-111. 10.1016/j.freeradbiomed.2009.10.028

Brahemi, Ghali, Burger, A. M., Westwell, Andrew and Brancale, Andrea 2010. Homology Modelling of Human E1 Ubiquitin Activating Enzyme. Letters in Drug Design & Discovery 7 (1) , pp. 57-62. 10.2174/157018010789869316

Bruyere, Helene, Westwell, Andrew and Jones, Arwyn Tomos 2010. Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification. Bioorganic & Medicinal Chemistry Letters 20 (7) , pp. 2200-2203. 10.1016/j.bmcl.2010.02.035

Daniels, Stephen, Md Tohid, Siti Farah, Velanguparackel, Winnie and Westwell, Andrew 2010. The role and future potential of fluorinated biomarkers in positron emission tomography. Expert Opinion on Drug Discovery 5 (3) , pp. 291-304. 10.1517/17460441003652967

Weekes, Ashley Ann, Dix, Matthew C., Bagley, Mark Christopher and Westwell, Andrew D. 2010. Rapid and convenient thermal or microwave-assisted synthesis of substituted 2-Phenylbenzothiazoles. Synthetic Communications 40 (20) , pp. 3027-3032. 10.1080/00397910903353739

Gan, F. F., Chua, Y. S., Scarmagnani, S., Palaniappan, P., Franks, M., Poobalasingam, T., Bradshaw, T. D., Westwell, Andrew and Hagen, T. 2009. Structure-activity analysis of 2 '-modified cinnamaldehyde analogues as potential anticancer agents. Biochemical and Biophysical Research Communications 387 (4) , pp. 741-747. 10.1016/j.bbrc.2009.07.104

Weekes, Ashley Ann and Westwell, Andrew 2009. 2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery. Current Medicinal Chemistry 16 (19) , pp. 2430-2440.

Kadri, Hachemi, Dale, Trevor Clive, Ewan, Kenneth Burnside Ramsay and Westwell, Andrew 2008. The design, synthesis and antitumour evaluation of novel small molecule inhibitors of the Dishevelled PDZ domain [Poster Presentation/Abstract]. EJC Supplements 6 (12) , p. 137. 10.1016/S1359-6349(08)72370-X

Huber, Kelly, Patel, Poulam, Zhang, Lei, Evans, Helen, Westwell, Andrew D., Fischer, Peter M., Chan, Stephen and Martin, Stewart 2008. 2- [(1-methylpropyl)dithio] -1H-imidazole inhibits tubulin polymerization through cysteine oxidation. Molecular Cancer Therapeutics 7 (1) , pp. 143-151. 10.1158/1535-7163.mct-07-0486

Aiello, Stefania, Wells, Geoffrey, Stone, Erica L., Kadri, Hachemi, Bazzi, Rana, Bell, David R., Stevens, Malcolm F. G., Matthews, Charles S., Bradshaw, Tracey D. and Westwell, Andrew 2008. Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). Journal of Medicinal Chemistry 51 (16) , pp. 5135-5139. 10.1021/jm800418z

Brahemi, Ghali, Fiasella, A., Brancale, Andrea, Westwell, Andrew and Burger, A. 2008. Design and synthesis of BCA2 inhibitors. EJC Supplements 6 (12) , p. 44.

Callister, M.E., Pinhu, L., Catley, M.C., Westwell, Andrew, Newton, R., Leaver, S.K., Quinlan, G.J., Evans, T.W., Griffiths, M. J. and Burke-Gaffney, A. 2008. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappa B-dependent proinflammatory activation of alveolar epithelial cells. British Journal of Pharmacology 155 (5) , pp. 661-672. 10.1038/bjp.2008.258

Kadri, Hachemi, Matthews, C. S., Bradshaw, T. D., Stevens, M. F. G. and Westwell, Andrew 2008. Synthesis and antitumour evaluation of novel 2-phenylbenzimidazoles. Journal of Enzyme Inhibition and Medicinal Chemistry 23 (5) , pp. 641-647. 10.1080/14756360802205398

Ziedan, Noha, Kadri, Hachemi and Westwell, Andrew 2008. The development of pro-apoptotic cancer therapeutics. Mini-Reviews in Medicinal Chemistry 8 (7) , pp. 711-718.

Westwell, Andrew 2008. Advances in Cancer Drug Discovery - A British Association for Cancer Research Meeting. IDrugs 11 (11) , pp. 783-786.

White, Alex William, Westwell, Andrew and Brahemi, Ghali 2008. Protein-protein interactions as targets for small-molecule therapeutics in cancer. Expert Reviews in Molecular Medicine 10 (e8) , pp. 1-14. 10.1017/S1462399408000641

Ziedan, Noha, Westwell, Andrew and Fogli, S. 2008. Design and synthesis of novel indole derivatives as selective apoptosis-inducers. EJC Supplements 6 (12) , pp. 45-46.

Athanasiou, A., Clarke, A. B., Turner, A. E., Kumaran, N. M., Vakilpour, S., Smith, P. A., Bagiokou, D., Bradshaw, T. D., Westwell, Andrew, Fang, L., Lobo, D. N., Constantinescu, C. S., Calabrese, V., Loesch, A., Alexander, S. P. H., Clothier, R. H., Kendall, D. A. and Bates, T. E. 2007. Cannabinoid receptor agonists are mitochondrial inhibitors: A unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications 364 (1) , pp. 131-137. 10.1016/j.bbrc.2007.09.107

Athanasiou, A., Smith, P. A., Vakilpour, S., Kumaran, N. M., Turner, A. E., Bagiokou, D., Layfield, R., Ray, D. E., Westwell, Andrew, Alexander, S. P. H., Kendall, D. A., Lobo, D. N., Watson, S. A., Lophatanon, A., Muir, K. A., Guo, D. A. and Bates, T. E. 2007. Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications 354 (1) , pp. 50-55. 10.1016/j.bbrc.2006.12.179

Henriksen, G., Hauser, A. I., Westwell, Andrew, Yousefi, B. H., Schwaiger, M., Drzezga, A. and Wester, H. J. 2007. Metabolically stabilized benzothiazoles for imaging of amyloid plaques. Journal of Medicinal Chemistry 50 (6) , pp. 1087-1089. 10.1021/jm061466g

Matsuura, T., Harrison, R. A., Westwell, Andrew, Nakamura, H., Martynyuk, A. E. and Sumners, C. 2007. Basal and angiotensin II-inhibited neuronal delayed-rectifier K+ current are regulated by thioredoxin. American Journal of Physiology -Cell Physiology 293 (1) , C211-C217. 10.1152/ajpcell.00615.2006

Shah, P. and Westwell, Andrew 2007. The role of fluorine in medicinal chemistry. Journal of Enzyme Inhibition and Medicinal Chemistry 22 (5) , pp. 527-540. 10.1080/14756360701425014

Westwell, Andrew D, Mortimer, CG, Wells, G and Crochard, JP 2006. Antitumor benzothiazoles. 26. 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. Journal of Medicinal Chemistry 49 (1) , pp. 179-185. 10.1021/jm050942k

Westwell, Andrew D, Berry, JM, Bradshaw, TD and Fichtner, I 2005. Quinols as novel therapeutic agents. 2. 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents. Journal of Medicinal Chemistry 48 (2) , pp. 639-644. 10.1021/jm040859h

Westwell, Andrew D, Wells, G, Berry, JM and Bradshaw, TD 2003. 4-Substituted-4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines. Journal of Medicinal Chemistry 46 (4) , pp. 532-541. 10.1021/jm020984y

Hutchinson, Ian, Chua, Mei-Sze, Browne, Helen L., Trapani, Valentina, Bradshaw, Tracey D., Westwell, Andrew D and Stevens, Malcolm F. G. 2001. Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles. Journal of Medicinal Chemistry 44 (9) , pp. 1446-1455. 10.1021/jm001104n