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Number of items: 48.

Hütten, Matthias C., Fehrholz, Markus, Konrad, Franziska M., Ophelders, Daan, Kleintjes, Clementine, Ottensmeier, Barbara, Spiller, Owen Brad, Glaser, Kirsten, Kramer, Boris W. and Kunzmann, Steffen 2019. Detrimental effects of an inhaled phosphodiesterase-4 inhibitor on lung inflammation in ventilated preterm lambs exposed to chorioamnionitis are dose dependent. Journal of Aerosol Medicine and Pulmonary Drug Delivery , -. 10.1089/jamp.2019.1528
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van Gorp, Charlotte, de Lange, Ilse H., Spiller, Owen B., Dewez, Frédéric, Cillero Pastor, Berta, Heeren, Ron M. A., Kessels, Lilian, Kloosterboer, Nico, van Gemert, Wim G., Beeton, Michael L., Stock, Sarah J., Jobe, Alan H., Payne, Matthew S., Kemp, Matthew W., Zimmermann, Luc J., Kramer, Boris W., Plat, Jogchum and Wolfs, Tim G. A. M. 2019. Protection of the ovine fetal gut against ureaplasma-induced chorioamnionitis: a potential role for plant sterols. Nutrients 11 (5) , -. 10.3390/nu11050968

Yang, Qiu, Li, Mei, Spiller, Owen, Andrey, Diego, Hinchliffe, Philip, Li, Hui, MacLean, Craig, Niumsup, Pannika, Powell, Lydia, Pritchard, Manon, Papkou, Andrei, Shen, Yingbo, Portal, Edward, Sands, Kirsty, Spencer, James, Tansawai, Uttapoln, Thomas, David, Wang, Shaolin, Wang, Yang, Shen, Jianzhong and Walsh, Timothy 2017. Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms. Nature Communications 8 , 2054 (2017). 10.1038/s41467-017-02149-0

Gussenhoven, R., Ophelders, D. R. M. G., Kemp, M., Payne, M. S., Spiller, Owen Bradley, Beeton, M.L., Stock, S., Cillero-Pastor, B., Barre, F. P. Y., Heeren, R. M. A., Kessels, L., Stevens, B., Rutten, B. P., Kallapur, S. G., Jobe, A. H., Kramer, B. W. and Wolfs, T. G. A. M. 2017. The paradoxical effects of chronic intra-amniotic Ureaplasma exposure on ovine fetal brain development. Developmental Neuroscience 39 (6) , pp. 472-486. 10.1159/000479021

Willems, Monique G. M., Kemp, Matthew W., Fast, Laura A., Wagemaker, Nick M. M., Janssen, Leon E. W., Newnham, John P., Payne, Matt S., Spiller, Owen Bradley, Kallapur, Suhas G., Jobe, Alan H., Delhaas, Tammo, Kramer, Boris W. and Wolfs, Tim G. A. M. 2017. Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide. PLoS ONE 12 (6) , e0180114. 10.1371/journal.pone.0180114

Spiller, Owen Bradley 2017. Emerging pathogenic respiratory mycoplasma hominis infections in lung transplant patients: time to reassesses it's role as a pathogen? EBioMedicine 19 , pp. 8-9. 10.1016/j.ebiom.2017.05.002

Hillitt, K. L., Jenkins, R. E., Spiller, Owen Bradley and Beeton, M. L. 2017. Antimicrobial activity of Manuka honey against antibiotic resistant strains of the cell wall free bacteria ureaplasma parvum and Ureaplasma urealyticum. Letters In Applied Microbiology 64 (3) , pp. 198-202. 10.1111/lam.12707

Beeton, Michael and Spiller, Owen Bradley 2017. Antibiotic resistance among Ureaplasma spp isolates: cause for concern? Journal of Antimicrobial Chemotherapy 72 (2) , pp. 330-337. 10.1093/jac/dkw425

Kemp, Matthew, Ahmed, Shatha, Beeton, Michael, Payne, Matthew, Saito, Masashi, Miura, Yuishira, Usuda, Hiro, Kallapur, Suhas, Kramer, Boris, Stock, Sarah, Jobe, Alan, Newnham, John and Spiller, Owen Bradley 2017. Fetal Ureaplasma parvum bacteraemia as a function of gestation-dependent complement insufficiency: evidence from a sheep model of pregnancy. American Journal of Reproductive Immunology 77 (1) , e12599. 10.1111/aji.12599

Stock, Sarah J., Patey, Olga, Thilaganathan, Basky, White, Scott, Furfaro, Lucy L., Payne, Matthew S., Spiller, Owen, Noé, Andres, Watts, Rory, Carter, Sean, Ireland, Demelza J., Jobe, Alan H., Newnham, John P. and Kemp, Matthew W. 2017. Intrauterine Candida albicans infection causes systemic fetal candidiasis with progressive cardiac dysfunction in a sheep model of early pregnancy. Reproductive Sciences 24 (1) , pp. 77-84. 10.1177/1933719116649697

Jironkin, Aleksey, Brown, Rebecca J, Underwood, Anthony, Chalker, Victoria J and Spiller, Owen 2016. Genomic determination of minimum multi-locus sequence typing schemas to represent the genomic phylogeny of Mycoplasma hominis. BMC Genomics 17 10.1186/s12864-016-3284-z

Aboklaish, Ali, Ahmed, S., McAllister, D., Cassell, G., Zheng, X. and Spiller, Owen Bradley 2016. Differential recognition of the Multiple Banded Antigen isoforms across Ureaplasma parvum and Ureaplasma urealyticum species by monoclonal antibodies. Journal of Microbiological Methods 127 , pp. 13-19. 10.1016/j.mimet.2016.05.015

Beeton, Michael, Maxwell, N. C., Chalker, V. J., Brown, Rebecca, Aboklaish, Ali F. and Spiller, Owen Bradley 2016. Isolation of separate Ureaplasma species from endotracheal secretions of twin patients. Pediatrics 138 (2) 10.1542/peds.2016-0565

Brown, Rebecca, Nguipdop-Djomo, Patrick, Zhao, Hongxin, Stanford, Elaine, Spiller, Owen Bradley and Chalker, Victoria J. 2016. Mycoplasma pneumoniae epidemiology in England and Wales: a national perspective. Frontiers in Microbiology 7 , 157. 10.3389/fmicb.2016.00157

Kemp, Matthew W., Molloy, Timothy J., Usuda, Haruo, Woodward, Eleanor, Miura, Yuichiro, Payne, Matthew S., Ireland, Demelza J., Jobe, Alan H., Kallapur, Suhas G., Stock, Sarah J., Spiller, Owen Bradley, Newnham, John P. and Saito, Masatoshi 2016. Outside-in? Acute fetal systemic inflammation in very preterm chronically catheterized sheep fetuses is not driven by cells in the fetal blood. American Journal of Obstetrics and Gynecology 214 (2) , 281.e1-281.e10. 10.1016/j.ajog.2015.09.076

Beeton, Michael L., Chalker, Victoria J., Jones, Lucy C., Maxwell, Nicola C. and Spiller, Owen Bradley 2016. Antibiotic resistance among clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013. Antimicrobial Agents and Chemotherapy 60 (1) , pp. 52-56. 10.1128/AAC.00889-15

Nesargikar, Prabhu, Pino-Chavez, Gilda, Spiller, Owen Bradley, Fraser, Donald James, Jenkins, Robert Hywel and Chavez, Rafael 2015. Single dose sCR1 attenuates renal ischemia reperfusion injury in rats despite early reconstitution of the complement system [Abstract]. Transplant International 28 (S4) , p. 62. 10.1111/tri.12700

Brown, Rebecca, Spiller, Owen Bradley and Chalker, Victoria J 2015. Molecular typing of mycoplasma pneumoniae: where do we stand? Future Microbiology 10 (11) , pp. 1793-1795. 10.2217/fmb.15.96

Brown, Rebecca, Holden, Matthew T. G., Spiller, Owen Bradley, Chalker, Victoria J. and Ledeboer, N. A. 2015. Development of a multilocus sequence typing scheme for molecular typing of mycoplasma pneumoniae. Journal of Clinical Microbiology 53 (10) , pp. 3195-3203. 10.1128/JCM.01301-15

Furfaro, Lucy L., Spiller, Owen Bradley, Keelan, Jeffrey A. and Payne, Matthew S. 2015. In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin. International Journal of Antimicrobial Agents 46 (3) , pp. 319-324. 10.1016/j.ijantimicag.2015.04.015

Ahmed, Shatha, Kemp, Matthew W., Payne, Matthew S., Kallapur, Suhas G., Stock, Sarah J., Marsh, Henry C., Jobe, Alan H., Newnham, John P. and Spiller, Owen Bradley 2015. Comparison of complement activity in adult and preterm sheep serum. American Journal of Reproductive Immunology 73 (3) , pp. 232-241. 10.1111/aji.12299

Aboklaish, Ali, Dordet-Frisoni, Emilie, Citti, Christine, Toleman, Mark A, Glass, John I. and Spiller, Owen Bradley 2014. Random insertion and gene disruption via transposon mutagenesis of Ureaplasma parvum using a mini-transposon plasmid. International Journal of Medical Microbiology 304 (8) , pp. 1218-1225. 10.1016/j.ijmm.2014.09.003

Kemp, M. W., Miura, Y., Payne, M. S., Jobe, A. H., Kallapur, S. G., Saito, M., Stock, S. J., Spiller, Owen Bradley, Ireland, D. J., Yaegashi, N., Clarke, M., Hahne, D., Rodger, J., Keelan, J. A. and Newnham, J. P. 2014. Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy. Antimicrobial Agents and Chemotherapy 58 (11) , pp. 6581-6591. 10.1128/AAC.03721-14

Kemp, Matthew W., Miura, Yuichiro, Payne, Matthew S., Watts, Rory, Megharaj, Smruthi, Jobe, Alan H., Kallapur, Suhas G., Saito, Masatoshi, Spiller, Owen Bradley, Keelan, Jeffrey A. and Newnham, John P. 2014. Repeated maternal intramuscular or intraamniotic erythromycin incompletely resolves intrauterine Ureaplasma parvum infection in a sheep model of pregnancy. American Journal of Obstetrics and Gynecology 211 (2) , 134.e1-134.e9. 10.1016/j.ajog.2014.02.025

Lowe, John, Watkins, William, Edwards, Martin, Spiller, Owen, Jacqz-Aigrain, Evelyne, Kotecha, Sarah and Kotecha, Sailesh 2014. Association between pulmonary Ureaplasma colonization and bronchopulmonary dysplasia in preterm infants: updated systematic review and meta-analysis. The Pediatric Infectious Disease Journal 33 (7) , pp. 697-702. 10.1097/INF.0000000000000239

Miura, Y., Payne, M. S., Keelan, J. A., Noe, A., Carter, S., Watts, R., Spiller, Owen Bradley, Jobe, A. H., Kallapur, S. G., Saito, M., Stock, S. J., Newnham, J. P. and Kemp, M. W. 2014. Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection. Antimicrobial Agents and Chemotherapy 58 (9) , pp. 5413-5420. 10.1128/AAC.03187-14

Van Den Berg, Carmen, Tambourgi, Denise V., Clark, Howard W., Hoong, S. Julie, Spiller, Owen and McGreal, Eamon 2014. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. The Journal of Immunology 192 (4) , pp. 1787-1795. 10.4049/jimmunol.1301920

Brown, Rebecca, Chalker, Victoria J. and Spiller, Owen Bradley 2014. Mycoplasma hominis variable adherence-associated antigen: A major adhesin and highly variable surface membrane protein. Advances in Microbiology 04 (11) , pp. 736-746. 10.4236/aim.2014.411080

Payne, M. S., Tabone, T., Kemp, M. W., Keelan, J. A., Spiller, Owen Bradley, Newnham, J. P. and Carroll, K. C. 2013. High-resolution melt PCR analysis for genotyping of Ureaplasma parvum isolates directly from clinical samples. Journal of Clinical Microbiology 52 (2) , pp. 599-606. 10.1128/JCM.03036-13

Triantafilou, Martha, De Glanville, Benjamin, Aboklaish, Ali F., Spiller, Owen Bradley, Kotecha, Sailesh and Triantafilou, Kathy 2013. Synergic activation of Toll-Like Receptor (TLR) 2/6 and 9 in response to ureaplasma parvum & urealyticum in human amniotic epithelial cells. PLoS ONE 8 (4) , e61199. 10.1371/journal.pone.0061199

Beeton, Michael L., Daha, Mohamed R., El-Shanawany, Tariq, Jolles, Stephen, Kotecha, Sailesh and Spiller, Owen Bradley 2012. Serum killing of 'ureaplasma parvum' shows serovar-determined susceptibility for normal individuals and common variable immuno-deficiency patients. Immunobiology 217 (2) , pp. 187-194. 10.1016/j.imbio.2011.07.009

McGreal, Eamon Patrick, Hearne, Keziah and Spiller, Owen Bradley 2012. Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth. Immunobiology 217 (2) , pp. 176-186. 10.1016/j.imbio.2011.07.027

Pinkert, Sandra, Klingel, Karin, Lindig, Vanessa, Dorner, Andrea, Zeichhardt, Heinz, Spiller, Owen Bradley and Fechner, Henry 2011. Virus-host coevolution in a persistently coxsackievirus B3-infected cardiomyocyte cell line. Journal of Virology 85 (24) , pp. 13409-13419. 10.1128/JVI.00621-11

Beeton, Michael L., Maxwell, Nicola C., Davies, Philip Lloyd, Nuttall, Diane, McGreal, Eamon Patrick, Chakraborty, Mallinath, Spiller, Owen Bradley and Kotecha, Sailesh 2011. Role of pulmonary infection in the development of chronic lung disease of prematurity. European Respiratory Journal 37 (6) , pp. 1424-1430. 10.1183/09031936.00037810

McGreal, Eamon Patrick, Davies, Philip Lloyd, Powell, Wendy, Rose-John, Stefan, Spiller, Owen Bradley, Doull, Iolo John Manley, Jones, Simon Arnett and Kotecha, Sailesh 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802 (7-8) , pp. 649-658. 10.1016/j.bbadis.2010.04.005

Davies, Philip Lloyd, Spiller, Owen Bradley, Beeton, Michael L., Maxwell, Nicola Claire, Remold-O'Donnell, Eileen and Kotecha, Sailesh 2010. Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity. Thorax 65 (3) , pp. 246-251. 10.1136/thx.2009.116061

Beeton, Michael L., Chalker, Victoria J., Maxwell, Nicola C., Kotecha, Sailesh and Spiller, Owen Bradley 2009. Concurrent titration and determination of antibiotic resistance in 'ureaplasma' species with identification of novel point mutations in genes associated with resistance. Antimicrobial Agents and Chemotherapy 53 (5) , pp. 2020-2027. 10.1128/AAC.01349-08

Wall, Sion R., Wat, Dennis, Spiller, Owen Bradley, Gelder, Colin M., Kotecha, Sailesh and Doull, Iolo John Manley 2009. The viral aetiology of croup and recurrent croup. Archives of Disease in Childhood 94 (5) , pp. 359-360. 10.1136/adc.2008.142984

Okroj, Marcin, Mark, Linda, Stokowska, Anna, Wong, Scott W., Rose, Nicola, Blackbourn, David J., Villoutreix, Bruno O., Spiller, Owen Bradley and Blom, Anna M. 2009. Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP). Journal of Biological Chemistry 284 (1) , pp. 505-514. 10.1074/jbc.M806669200

Beeton, Michael L., Chalker, Victoria J., Kotecha, Sailesh and Spiller, Owen Bradley 2009. Comparison of full gyrA, gyrB, parC and parE gene sequences between all Ureaplasma parvum and Ureaplasma urealyticum serovars to separate true fluoroquinolone antibiotic resistance mutations from non-resistance polymorphism. Journal of Antimicrobial Chemotherapy 64 (3) , pp. 529-538. 10.1093/jac/dkp218

Pinkert, Sandra, Westermann, Dirk, Wang, Xiaomin, Klingel, Karin, Dorner, Andrea, Savvatis, Konstantinos, Grossl, Tobias, Krohn, Stefanie, Tschope, Carsten, Zeichhardt, Heinz, Kotsch, Katja, Weitmann, Kerstin, Hoffmann, Wolfgang, Schultheiss, Heinz-Peter, Spiller, Owen Bradley, Poller, Wolfgang and Fechner, Henry 2009. Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor. Circulation 120 (23) , pp. 2358-2366. 10.1161/CIRCULATIONAHA.108.845339

Griesche, Nadine, Zikos, Dimitrios, Witkowski, Peter, Nitsche, Andreas, Ellerbrok, Heinz, Spiller, Owen Bradley, Pauli, Georg and Biere, Barbara 2008. Growth characteristics of human adenoviruses on porcine cell lines. Virology 373 (2) , pp. 400-410. 10.1016/j.virol.2007.12.015

Mark, L., Proctor, D. G., Blackbourn, D. J., Blom, A. M. and Spiller, Owen Bradley 2008. Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies. Immunology 123 (2) , pp. 228-238. 10.1111/j.1365-2567.2007.02692.x

Davies, Philip Lloyd, Maxwell, Nicola C., Kotecha, Sailesh and Spiller, Owen Bradley 2008. Monoclonal anti-neutrophil elastase antibody characterisation: ability to block function, detect free versus serpin-complexed enzyme and stain intracellular granules. Journal of Immunological Methods 336 (2) , pp. 175-182. 10.1016/j.jim.2008.04.010

Spiller, Owen Bradley, Mark, Linda, Blue, C. E., Proctor, David Gwyn, Aitken, J. A., Blom, Anna M. and Blackbourn, David J. 2006. Dissecting the regions of virion-associated Kaposi's sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding. Journal of Virology 80 (8) , pp. 4068-4078. 10.1128/JVI.80.8.4068-4078.2006

Spiller, Owen Bradley, Goodfellow, I. G., Evans, Darrell and Blom, A. M. 2005. Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered particle formation, and competition with cellular receptors. Journal of Virology 79 (18) , pp. 12016-12024. 10.1128/JVI.79.18.12016-12024.2005

Spiller, Owen Bradley, Blackbourn, David J., Mark, Linda, Proctor, David Gwyn and Blom, Anna M. 2003. Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. Journal of Biological Chemistry 278 (11) , pp. 9283-9289. 10.1074/jbc.M211579200

Spiller, Owen Bradley, Robinson, Mairi, O'Donnell, Elizabeth, Milligan, Steven, Morgan, Bryan Paul, Davison, Andrew J. and Blackbourn, David J. 2003. Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. Journal of Virology 77 (1) , pp. 592-599. 10.1128/JVI.77.1.592-599.2003

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