Browse by All Cardiff Authors

Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Ghazaly, Essam and Pepper, Chris 2022. Synthesis and characterization of nuc-7738, an aryloxy phosphoramidate of 3?-deoxyadenosine, as a potential anticancer agent. Journal of Medicinal Chemistry 65 (23) , pp. 15789-15804. 10.1021/acs.jmedchem.2c01348

Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Ghazaly, Essam, Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Pepper, Chris 2021. Single diastereomers of the clinical anticancer ProTide agents NUC-1031 and NUC-3373 preferentially target cancer stem cells in vitro. Journal of Medicinal Chemistry 64 (12) , pp. 8179-8193. 10.1021/acs.jmedchem.0c02194

Kandil, Sahar B. ORCID: https://orcid.org/0000-0003-1806-9623, Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2021. Synthesis, biological evaluation and X-ray analysis of bicalutamide sulfoxide analogues for the potential treatment of prostate cancer. Bioorganic and Medicinal Chemistry Letters 36 , 127817. 10.1016/j.bmcl.2021.127817

Kandil, Sahar B. ORCID: https://orcid.org/0000-0003-1806-9623, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2021. Synthesis and biological evaluation of bicalutamide analogues for the potential treatment of prostate cancer. Molecules 26 (1) , 56. 10.3390/molecules26010056

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Pileggi, Elisa, Richards, Jennifer, Wootton, Mandy, Van Leemputte, Thijs, Persoons, Leentje, De Coster, David, Villanueva, Xabier, Daelemans, Dirk, Steenackers, Hans, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2020. Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials. Journal of Antimicrobial Chemotherapy 75 (10) , pp. 2864-2878. 10.1093/jac/dkaa268

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Pannecouque, Christophe, Chapman, Fiona M., Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2019. Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity. Bioorganic and Medicinal Chemistry Letters 29 (24) , 126721. 10.1016/j.bmcl.2019.126721

Derudas, Marco, Vanpouille, Christophe, Carta, Davide, Zicari, Sonia, Andrei, Graciela, Snoeck, Robert, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Margolis, Leonid, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2017. Virtual screening of acyclovir derivatives as potential antiviral agents: design, synthesis, and biological evaluation of new acyclic nucleoside protides. Journal of Medicinal Chemistry 60 (18) , pp. 7876-7896. 10.1021/acs.jmedchem.7b01009

James, Edward, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2017. Kinase-independent phosphoramidate S1P1 receptor agonist benzyl ether derivatives. Biorganic and Medicinal Chemistry Letters 27 (6) , pp. 1371-1378. 10.1016/j.bmcl.2017.02.011

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Balzarini, Jan, Rat, Stephanie, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites. Biorganic and Medicinal Chemistry Letters 26 (23) , pp. 5618-5623. 10.1016/j.bmcl.2016.10.077

Bassetto, Marcella, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118 , pp. 230-243. 10.1016/j.ejmech.2016.04.052

Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Bassetto, Marcella, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic and Medicinal Chemistry Letters 26 (15) , pp. 3636-3640. 10.1016/j.bmcl.2016.06.001

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Meneghesso, Silvia, Derudas, Marco, Farleigh, Laura, Zanetta, Paola and Bugert, Joachim ORCID: https://orcid.org/0000-0002-0556-3211 2016. Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues. ChemistryOpen 5 (3) , pp. 227-235. 10.1002/open.201500216

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Wymant, Jennifer, Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110 , pp. 311-325. 10.1016/j.ejmech.2015.12.037

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. 7-Substituted umbelliferone derivatives as androgen receptor antagonists for the potential treatment of prostate and breast cancer. Biorganic and Medicinal Chemistry Letters 26 (8) , pp. 2000-2004. 10.1016/j.bmcl.2016.02.088

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2015. Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction. Chemical Communications 51 (38) , pp. 8070-8073. 10.1039/C5CC00448A

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2015. Symmetrical diamidate prodrugs of nucleotide analogues for drug delivery. Current Protocols in Nucleic Acid Chemistry, Wiley-Blackwell, 60:15.6.1-15.6.10. (10.1002/0471142700.nc1506s60)

Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2015. Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by the Schwartz's reagent. Nucleosides, Nucleotides & Nucleic Acids 34 (11) , pp. 799-814. 10.1080/15257770.2015.1075552

Meyer, Jan-Philip, Probst, Katrin C., Trist, Iuni Margaret, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236 2014. A novel radiochemical approach to 1-(2 '-deoxy-2 '-[F-18] fluoro-beta-D-arabinofuranosyl)cytosine (F-18-FAC). Journal of Labelled Compounds and Radiopharmaceuticals 57 (11) , pp. 637-644. 10.1002/jlcr.3233

Toti, Kiran S., Derudas, Marco, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Sinnaeve, Davy, Van den Broeck, Freya, Margamuljana, Lia, Martins, José C., Herdewijn, Piet, Balzarini, Jan, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Van Calenbergh, Serge 2014. Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity. Journal of Organic Chemistry 79 (11) , pp. 5097-5112. 10.1021/jo500659e

Velanguparackel, Winnie, Hamon, Nadege, Balzarini, Jan, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2014. Synthesis, anti-HIV and cytostatic evaluation of 3′-deoxy-3′-fluorothymidine (FLT) pro-nucleotides. Bioorganic and Medicinal Chemistry Letters 24 (10) , pp. 2240-2243. 10.1016/j.bmcl.2014.03.092

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Hinsinger, Karen, Flynn, Áine Sinéad, Powell, Ned George, Tristram, Amanda Jane, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2014. PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer. European Journal of Medicinal Chemistry 78 , pp. 259-268. 10.1016/j.ejmech.2014.03.051

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Derudas, Marco, Gonczy, Blanka, Hinsinger, Karen, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Snoeck, Robert, Andrei, Graciela, Balzarini, Jan, McHugh, Timothy D., Maitra, Arundhati, Akorli, Ernest, Evangelopoulos, Dimitrios and Bhakta, Sanjib 2014. ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents. Bioorganic and Medicinal Chemistry 22 (9) , pp. 2816-2824. 10.1016/j.bmc.2014.02.056

Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Huerta Lopez, Monica, Balzarini, Jan, Mason, Malcolm ORCID: https://orcid.org/0000-0003-1505-2869, Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111, Blagden, Sarah, Thompson, Emely, Ghazaly, Essam and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2014. Application of ProTide technology to Gemcitabine: A successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development. Journal of Medicinal Chemistry 57 (4) , pp. 1531-1542. 10.1021/jm401853a

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Bourdin, Claire, Derudas, Marco, Hamon, Nadege, Hinsinger, Karen, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid and Balzarini, Jan 2013. Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry 70 , pp. 326-340. 10.1016/j.ejmech.2013.09.047

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2013. Evoked potentials are of little use in the diagnosis or monitoring of MS: Yes. Multiple Sclerosis Journal 19 (14) , pp. 1820-1821. 10.1177/1352458513505695

Quintiliani, Maurizio, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2013. Design, synthesis, and biological evaluation of C1-phosphonamidate analogues of 2-deoxy-d-ribose-1-phosphate. Tetrahedron 69 (43) , pp. 9111-9119. 10.1016/j.tet.2013.08.038

Ghazaly, Essam Ahmed, Joel, Simon, Gribben, John G., Mohammad, Tariq, Emiloju, Oluwadunni, Stavraka, Chara, Hopkins, Tom, Gabra, Hani, Wasan, Harpreet, Habib, Nagy A., Leonard, Robert C. F., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190 and Blagden, Sarah Patricia 2013. ProGem1: Phase I first-in-human study of the novel nucleotide NUC-1031 in adult patients with advanced solid tumors [Abstract]. Journal of Clinical Oncology 31 (15) , abstr. 2576.

Bourdin, Claire, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff, Gorovits, Elena, Kolykhalov, Alexander, Muhammad, Jerry, Patti, Joseph, Henson, Geoffrey, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Hunley, Damound, Obikhod, Aleksandr, Walters, C. Robin, Wang, Jin, Ramamurty, Changalvala V. S., Battina, Srinivas K. and Rao, C. Srinivas 2013. Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2 '-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates. Biorganic and Medicinal Chemistry Letters 23 (7) , pp. 2260-2264.

Bourdin, Claire, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff, Gorovits, Elena, Kolykhalov, Alexander, Muhammad, Jerry, Patti, Joseph, Henson, Geoffrey, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Hunley, Damound, Obikhod, Aleksandr, Walters, C. Robin, Wang, Jin, Ramamurty, Changalvala V. S., Battina, Srinivas K. and Rao, C.Srivinas 2013. Synthesis and evaluation against Hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates. Biorganic & Medicinal Chemistry Letters 23 (7) , pp. 2260-2264. 10.1016/j.bmcl.2012.12.004

Meneghesso, Silvia, Vanderlinden, Evelien, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Balzarini, Jan, Naesens, Lieve and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2013. Synthesis and biological evaluation of purine 2'-Fluoro-2'-deoxyriboside ProTides as anti-influenza virus agents. ChemMedChem 8 (3) , pp. 415-425. 10.1002/cmdc.201200562

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Hinsinger, Karen, Farleigh, Laura, Pathirana, Ranjith and Bugert, Joachim J. ORCID: https://orcid.org/0000-0002-0556-3211 2013. Novel antiviral activity of l-dideoxy bicyclic nucleoside analogues versus vaccinia and measles viruses in vitro. Journal of Medicinal Chemistry 56 (3) , pp. 1311-1322. 10.1021/jm301778x

Hamon, Nadege, Quintiliani, Maurizio, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2013. Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate. Biorganic and Medicinal Chemistry Letters 23 (9) , pp. 2555-2559. 10.1016/j.bmcl.2013.02.117

Vanpouille, Christopher, Lisco, Andrea, Introini, Andrea, Grivel, Jean-Charles, Munawwar, Arshi, Merbah, Melanie, Schinazi, Raymond F., Derudas, Marco, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Balzarini, Jan and Margolis, Leonid 2012. Exploiting the Anti-HIV-1 activity of acyclovir: Suppression of primary and drug-resistant HIV isolates and potentiation of the activity by Ribavirin. Antimicrobial Agents and Chemotherapy 56 (5) , pp. 2604-2611. 10.1128/AAC.05986-11

Vande Voorde, Johan, Quintiliani, Maurizio, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Liekens, Sandra and Balzarini, Jan 2012. Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-d-ribose-1-phosphate derivative. Biochemical Pharmacology 83 (10) , pp. 1358-1363. 10.1016/j.bcp.2012.02.005

Madela, Karolina and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2012. Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs. Future Medicinal Chemistry 4 (5) , pp. 625-650. 10.4155/fmc.12.10

Andrei, Graciela, Topalis, D., Fiten, P., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Balzarini, J., Opdenakker, G. and Snoeck, R. 2012. In Vitro-Selected drug-resistant Varicella-Zoster Virus mutants in the thymidine kinase and DNA polymerase genes yield novel Phenotype-Genotype associations and highlight differences between antiherpesvirus drugs. Journal of Virology 86 (5) , pp. 2641-2652. 10.1128/JVI.06620-11

Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Bibbo, Rita, Rat, Stephanie, Roberts, Helen Christina, Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877, Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661, Alcaraz, María José, Gibert, Anna Torrent, Verson, Carlos Raul Alaez and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2012. Novel phosphoramidate prodrugs of N-Acetyl-(d)-Glucosamine with antidegenerative activity on bovine and human cartilage explants. Journal of Medicinal Chemistry 55 (10) , pp. 4629-4639. 10.1021/jm300074y

Meneghesso, Silvia, Vanderlinden, Evelien, Stevaert, Annelies, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Balzarini, Jan and Naesens, Lieve 2012. Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus. Antiviral Research 94 (1) , pp. 35-43. 10.1016/j.antiviral.2012.01.007

Derudas, Marco and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2012. Serendipity and VZV drug discovery. Drug Discovery Today: Technologies 9 (3) , e177-e181. 10.1016/j.ddtec.2011.11.001

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Bourdin, Claire, Arrica, Maria, Barrett, Emma, Jones, Sarah Louise, Kolykhalov, Alexander, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Gorovits, Elena, Henson, Geoffrey, Hunley, Damound, Hutchins, Jeff, Muhammad, Jerry, Obikhod, Aleksandr, Patti, Joseph, Walters, C. Robin, Wang, Jin, Vernachio, John, Ramamurty, Changalvala V. S., Battina, Srinivas K. and Chamberlain, Stanley 2011. Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents. Journal of Medicinal Chemistry 54 (24) , pp. 8632-8645. 10.1021/jm2011673

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2011. Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy. Antiviral Chemistry and Chemotherapy 22 (5) , pp. 181-203. 10.3851/IMP2012

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Murziani, Paola, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Gonczy, Blanka, Vande Voorde, Johan, Liekens, Sandra and Balzarini, Jan 2011. Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside. Journal of Medicinal Chemistry 54 (20) , pp. 7247-7258. 10.1021/jm200815w

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Battina, S. K., Ramamurty, C. V. S., Rao, C. S., Vernachio, J., Hutchins, J., Hall, A., Kolykhalov, A., Henson, G. and Chamberlain, S. 2011. Dual pro-drugs of 2 '-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus. Biorganic and Medicinal Chemistry Letters 21 (19) , pp. 6007-6012. 10.1016/j.bmcl.2011.06.013

Voorde, J. V., Liekens, S., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Murziani, Paola G. S., Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190 and Balzarini, J. 2011. The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2 '-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes. Biochemical Pharmacology 82 (5) , pp. 441-452. 10.1016/j.bcp.2011.05.024

Quintiliani, Maurizio, Persoons, Leentje, Solaroli, Nicola, Karlsson, Anna, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2011. Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides. Bioorganic & Medicinal Chemistry 19 (14) , pp. 4338-4345. 10.1016/j.bmc.2011.05.037

Toti, K. S., Derudas, Marco, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Balzarini, J and Van Calenbergh, S 2011. Synthesis and antiviral evaluation of α-l-2'-deoxythreofuranosyl nucleosides. European Journal of Medicinal Chemistry

Hutchins, Jeff T., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Chamberlain, Stanley D., Madela, Karolina W., Aljarah, Mohamed, Vernachio, John, Patti, Joseph M. and Henson, Geoffrey 2011. DMPK and Metabolism Studies of Nucleoside Phosphoramidates Including INX-08189, A Novel Double Pro-drug and Clinical Candidate for Hepatitis C Virus Therapy. Antiviral Research 90 (2) , A22-A23. 10.1016/j.antiviral.2011.03.006

van Kuppeveld, Frank, Snijder, Eric, Gorbalenya, Alexander, Canard, Bruno, Bartenschlager, Ralf, Neyts, Johan, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2011. European Training Network on (+)RNA Virus Replication and Antiviral Drug Development [Abstract]. Antiviral Research 90 (2) , A64. 10.1016/j.antiviral.2011.03.129

Vernachio, John H., Bleiman, Blair, Bryant, K. Dawn, Chamberlain, Stanley, Hunley, Damound, Hutchins, Jeff, Ames, Brenda, Gorovits, Elena, Ganguly, Babita, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, C. Robin, Wang, Jin, Williams, Karen, Patti, Joseph M., Henson, Geoffrey, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2011. INX-08189, a phosphoramidate prodrug of 6-O-Methyl-2'-C-Methyl Guanosine, is a potent inhibitor of Hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties. Antimicrobial Agents and Chemotherapy 55 (5) , pp. 1843-1851. 10.1128/AAC.01335-10

University College Cardiff Consultants Limited, Katholieke Universiteit Leuven 2011. Anti-viral pyrimidine nucleoside derivatives. EP 2016081 B1. [Patent].

Trippier, Paul C., Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: bisphenylboronic acids. Antiviral Chemistry and Chemotherapy 21 (3) , pp. 129-142. 10.3851/IMP1707

Vernachio, J., Bryant, D., Chamberlain, S. D., Gorovits, E., Ganguly, B. S., Hall, A., Henson, G. W., Hunley, D. S., Hutchins, J. T., Muhammad, J., Patti, J., Walters, C. R., Wang, J., Madela, Karolina, Aljarah, Mohamed, Jones, Sarah Louise and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. In vitro and in vivo metabolism of INX-189, a potent HCV inhibitor, in rat and cynomolgus monkey hepatocytes [Abstract]. Hepatology 52 (S1) , 1218A-1219A. 10.1002/hep.23997

Kolykhalov, A., Liu, Y., Bleiman, B., Patti, J., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Vernachio, J. 2010. Characterization of in vitro selected hepatitis C virus replicon mutants resistant to the phosphoramidate analog of 2 '-C-Methylguanosine, INX-189 [Abstract]. Hepatology 52 (S1) , 1218A-1218A. 10.1002/hep.23997

Hall, A., Raja, N., Chamberlain, S. D., Gorovits, E., Henson, G. W., Hutchins, J. T., Muhammad, J., Patti, J., Vernachio, J., Wang, J., Madela, Karolina, Aljarah, Mohamed, Jones, Sarah Louise and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. Metabolite characterization of INX-189, a potent HCV inhibitor, in fresh human primary hepatocytes and human liver and kidney cell lines [abstract 1874]. Hepatology 52 (S1) , 1211A-1211A. 10.1002/hep.23996

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Zonta, Nicola, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff and Hall, Andrea 2010. Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus. Biorganic and Medicinal Chemistry Letters 20 (16) , pp. 4850-4854. 10.1016/j.bmcl.2010.06.094

Trippier, Paul C. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications. MedChemComm 1 (3) , pp. 183-198. 10.1039/c0md00119h

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Gilles, Arnaud, Madela, Karolina, Aljarah, Mohamed, Holl, Sabrina, Jones, Sarah Louise, Vernachio, John, Hutchins, Jeff, Ames, Brenda, Bryant, K. Dawn, Gorovits, Elena, Ganguly, Babita, Hunley, Damound, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, Robin, Wang, Jin, Chamberlain, Stanley and Henson, Geoffrey 2010. Phosphoramidate ProTides of 2'-C-Methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties. Journal of Medicinal Chemistry 53 (13) , pp. 4949-4957. 10.1021/jm1003792

Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513, Valente, Rocco, Mottram, Huw James, Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Mills, Kenneth Ian, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism. Bioorganic & Medicinal Chemistry 18 (7) , pp. 2439-2446. 10.1016/j.bmc.2010.02.059

Trippier, Paul Charles, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Balzarini, Jan 2010. Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: monophenylboronic acids. Antiviral Chemistry & Chemotherapy 20 , pp. 249-257. 10.3851/IMP1632

Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-β-D-(arabinofuranosyl)uracil phosphoramidate ProTides. Antiviral Chemistry & Chemotherapy 20 (4) , pp. 153-160. 10.3851/IMP1476

Derudas, Marco, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Naesens, L., Neyts, J., Balzarini, J. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin. Bioorganic & Medicinal Chemistry 18 (7) , pp. 2748-2755. 10.1016/j.bmc.2010.02.015

Vanpouille, C., Lisco, A., Derudas, Marco, Saba, E., Grivel, J. C., Brichacek, B., Scrimieri, F., Schinazi, R., Schols, D., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Balzarini, J. and Margolis, L. 2010. A New Class of Dual-Targeted Antivirals: Monophosphorylated Acyclovir Prodrug Derivatives Suppress Both Human Immunodeficiency Virus Type 1 and Herpes Simplex Virus Type 2. International Journal of Infectious Diseases 201 (4) , pp. 635-643. 10.1086/650343

Morgan, Alwena Haf, Hammond, Victoria Jayne, Morgan, Lloyd, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Tallman, Keri A., Garcia-Diaz, Yoel Ruslan, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Porter, Ned A., Murphy, Robert C. and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5 (12) , pp. 1919-1931. 10.1038/nprot.2010.162

Lane, Jane ORCID: https://orcid.org/0000-0002-1926-4909, Martin, Tracey ORCID: https://orcid.org/0000-0003-2690-4908, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Mason, Malcolm ORCID: https://orcid.org/0000-0003-1505-2869 and Jiang, Wen ORCID: https://orcid.org/0000-0002-3283-1111 2010. The differential expression of hCNT1 and hENT1 i n breast cancer and the possible impact on breast cancer therapy. Journal of Experimental Therapeutics and Oncology 8 (3) , pp. 203-210.

Derudas, Marco, Quintiliani, Maurizio, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. Evaluation of novel phosphoramidate ProTides of the 2′-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue. Antiviral Chemistry and Chemotherapy 21 (1) , pp. 15-31. 10.3851/IMP1661

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Derudas, Marco, Quintiliani, Maurizio, Andrei, Graciela, Snoeck, Robert, Henson, Geoffrey and Balzarini, Jan 2009. 2 '-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743. Biorganic and Medicinal Chemistry Letters 19 (22) , pp. 6264-6267. 10.1016/j.bmcl.2009.09.116

Derudas, Marco, Carta, Davide, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Vanpouille, Christophe, Lisco, Andrea, Margolis, Leonid, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2009. The application of phosphoramidate ProTide technology to acyclovir confers anti-HIV inhibition. Journal of Medicinal Chemistry 52 (17) , pp. 5520-5530. 10.1021/jm9007856

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Perrone, Plinio, Madela, Karolina and Neyts, Johan 2009. The phosphoramidate ProTide approach greatly enhances the activity of beta-2 '-C-methylguanosine against hepatitis C virus. Biorganic and Medicinal Chemistry Letters 19 (15) , pp. 4316-4320. 10.1016/j.bmcl.2009.05.122

Carta, Davide, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Margolis, L. and Balzarini, J. 2009. Synthesis and Evaluation of Novel Acyclovir Phosphoramidates as Anti-HIV Agents. Antiviral Research 82 (2) , A56. 10.1016/j.antiviral.2009.02.132

Derudas, Marco, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Margolis, L. and Balzarini, J. 2009. The Application of Phosphoramidate Protide Technology to Acyclovir confers Novel Anti-HIV Inhibition. Antiviral Research 82 (2) , A57. 10.1016/j.antiviral.2009.02.134

Derudas, Marco, Quintiliani, Maurizio, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Henson, G. and Balzarini, J. 2009. Design, Synthesis, and Biological Evaluation of Novel Fluoro Derivatives of BCNA. Antiviral Research 82 (2) , A57. 10.1016/j.antiviral.2009.02.135

Hutchins, J., Chanberlain, S., Chang, C., Ganguly, B., Gorovits, E., Hall, A., Henson, G., Kolykhalov, A., Liu, Y., Muhammad, J., Perrone, P., Gilles, A., Holl, Sabrina, Madela, Karolina, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Patti, J. 2009. In Vitro Activity and In Vivo Pharmacokinetics of Highly Potent Phosphoramidate Nucleoside Analogue Inhibitors of Hepatitis C NS5B. Antiviral Research 82 (2) , A28. 10.1016/j.antiviral.2009.02.047

Madela, Karolina, Perrone, P., Gilles, A., Neyts, J. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2009. Phosphoramidate Protides Greatly Enhance the Anti-HCV Activity of 2 '-Methylguanosine. Antiviral Research 82 (2) , A29-A30. 10.1016/j.antiviral.2009.02.051

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Balzarini, J. 2009. FV100 as a new approach for the possible treatment of varicella-zoster virus infection. Journal of Antimicrobial Chemotherapy 64 (4) , pp. 671-673. 10.1093/jac/dkp294

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Bidet, O., Derudas, Marco, Andrei, G., Snoeck, R. and Balzarini, J. 2009. Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus. Biorganic and Medicinal Chemistry 17 (8) , pp. 3025-3027. 10.1016/j.bmc.2009.03.022

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Daverio, F., Najera, I., Martin, J. A., Klumpp, K. and Smith, D. B. 2009. The application of the phosphoramidate ProTide approach confers micromolar potency against Hepatitis C virus on inactive agent 4 '-azidoinosine: Kinase bypass on a dual base/sugar modified nucleoside. Biorganic and Medicinal Chemistry Letters 19 (11) , pp. 3122-3124. 10.1016/j.bmcl.2009.03.138

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Kelleher, M. R., Perrone, P., Mulready, S., Luoni, G., Daverio, F., Rajyaguru, S., Le Pogam, S., Najera, I., Martin, J. A., Klumpp, K. and Smith, D. B. 2009. The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4 '-azidocytidine (R1479). Biorganic and Medicinal Chemistry Letters 19 (15) , pp. 4250-4254. 10.1016/j.bmcl.2009.05.099

Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513, Balzarini, J. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2009. An investigation into the anti-HIV activity of 2 ',3 '-didehydro-2 ',3 '-dideoxyuridine (d4U) and 2 ',3 '-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives. Organic and Biomolecular Chemistry 7 (12) , pp. 2548-2553. 10.1039/b904276h

Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513, Balzarini, J. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2009. Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells. Chemmedchem 4 (11) , pp. 1779-1791. 10.1002/cmdc.200900289

Roberts, Helen Christina, Serpi, M., Bibbo, R., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Gilbert, A. T., Verson, C. R. A., Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661 and Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877 2009. Chemically modified glucosamine inhibits the release of proteoglycan in a model system of articular cartilage degradation. International Journal of Experimental Pathology 90 (1) , A78-A79.

Tchesnokov, E. P., Obikhod, A., Massud, I., Lisco, A., Vanpouille, C., Brichacek, B., Balzarini, J., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Derudas, Marco, Margolis, L., Schinazi, R. F. and Gotte, M. 2009. Mechanisms Associated with HIV-1 Resistance to Acyclovir by the V75I Mutation in Reverse Transcriptase. Journal of Biological Chemistry 284 (32) , pp. 21496-21504. 10.1074/jbc.M109.024026

Roberts, Helen Christina, Serpi, M., Bibbo, R., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Gilbert, A., Verson, C. R. A., Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661 and Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877 2009. Chemically modified glucosamine inhibits the release of proteoglycan in a model system of articular cartilage degradation [Abstract]. International Journal of Experimental Pathology 90 (1) , A78-A79. 10.1111/j.1365-2613.2008.00612.x

Lisco, Andrea, Vanpouille, Christophe, Tchesnokov, Egor P., Grivel, Jean Charles, Biancotto, Angélique, Brichacek, Beda, Elliott, Julie, Fromentin, Emilie, Shattock, Robert, Anton, Peter, Gorelick, Robert, Balzarini, Jan, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Derudas, Marco, Gotte, Matthias, Schinazi, Raymond F. and Margolis, Leonid. 2008. Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Cell Host & Microbe 4 (3) , pp. 260-270. 10.1016/j.chom.2008.07.008

Adak, Rina, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Snoeck, R., Andrei, G., Balzarini, J., Gorovits, E., Chang, C., Ames, B., Liu, Y. and Vernachio, J. 2008. Design and synthesis of novel non-nucleoside anti-HCMV agents [Abstract]. Antiviral Research 78 (2) , A52. 10.1016/j.antiviral.2008.01.107

Derudas, Marco, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Neyts, J. and Balzarini, J. 2008. Application of the phosphoramidate protide approach to the antiviral drug ribavirin. Antiviral Research 78 (2) , 55. 10.1016/j.antiviral.2008.01.115

Derudas, Marco, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Bugert, Joachim Jakob ORCID: https://orcid.org/0000-0002-0556-3211, Andrei, G., Snoeck, R. and Balzarini, J. 2008. Design, synthesis and biological evaluation of novel acyclovir ProTides. Antiviral Research 78 (2) , A55-A56. 10.1016/j.antiviral.2008.01.116

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Derudas, Marco, Bugert, Joachim Jakob ORCID: https://orcid.org/0000-0002-0556-3211, Andrei, G., Snoeck, R. and Balzarini, J. 2008. Successful kinase bypass with new acyclovir phosphoramidate prodrugs. Biorganic and Medicinal Chemistry Letters 18 (15) , pp. 4364-4367. 10.1016/j.bmcl.2008.06.069

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Migliore, Marco, Henson, G., Patti, J., Andrei, G., Snoeck, R. and Balzarini, J. 2008. Design, synthesis and evaluation of novel Anti-VZV BCNAs. Antiviral Research 78 (2) , 29. 10.1016/j.antiviral.2008.01.047

Yoo, C. B., Valente, R., Congiatu, C., Gavazza, F., Angell, A., Siddiqui, M. A., Jones, P. A., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Marquez, V. E. 2008. Activation of p16 Gene Silenced by DNA Methylation in Cancer Cells by Phosphoramidate Derivatives of 2 '-Deoxyzebularine. Journal of Medicinal Chemistry 51 (23) , pp. 7593-7601. 10.1021/jm8005965

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Bibbo, Rita, Roberts, Helen Christina, Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877, Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661, Gibert, Ana Torrent and Verson, Carlos Raul Alaez 2008. Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery. Journal of Medicinal Chemistry 51 (18) , pp. 5807-5812. 10.1021/jm800594c

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Pathirana, Ranjith N., Migliore, Marco, Adak, Rina, Luoni, Giovanna maria, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905, Díez-Torrubia, Alberto, Camarasa, Maria-Jose, Velázquez, Sonsoles, Henson, Geoffrey, Verbeken, Erik, Sienaer, Rebecca, Naesens, Lieve, Snoeck, Robert, Andrei, Graciela and Balzarini, Jan 2007. Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus. Journal of Antimicrobial Chemotherapy 60 (6) , pp. 1316-1330. 10.1093/jac/dkm376

Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Balzarini, J. 2007. Design, synthesis, and anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U), 2',3'-dideoxyuridine (ddU) phosphoramidate "ProTide' derivatives. Biorganic and Medicinal Chemistry Letters 17 (13) , pp. 3666-3669. 10.1016/j.bmcl.2007.04.043

Adak, Rina, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Snoeck, R., Andrei, G., De Clercq, E. and Balzarini, J. 2007. Design and synthesis of novel anti-HCMV agents: Modifications to the bicyclic pyrimidine base. Antiviral Research 74 (3) , A71. 10.1016/j.antiviral.2007.01.114

Congiatu, C., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 2007. HINT as putative phosphoramidase responsible of pro-tides activation: Molecular modelling studies [Abstract]. Antiviral Research 74 (3) , A71. 10.1016/j.antiviral.2007.01.115

Derudas, Marco, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Snoeck, R., Andrei, G., De Clercq, E. and Balzarini, J. 2007. Design, synthesis, and biological evaluation of novel anti-VZV agents. Antiviral Research 74 (3) , A72. 10.1016/j.antiviral.2007.01.116

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Perrone, P., Luoni, G., Kelleher, M. R., Daverio, F., Angell, A., Mulready, S., Congiatu, C., Rajyaguru, S., Martin, J., Leveque, V., Le Pogam, S., Najera, I., Klumpp, K. and Smith, D. 2007. Sub micromolar inhibitors of HCV generated from inactive nucleosides by application of ProTide technology [Abstract]. Antiviral Research 74 (3) , A36-A37. 10.1016/j.antiviral.2007.01.032

Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Balzarini, J. 2007. The design, synthesis and Anti-HIV activity of a selected group of 2 ',3 '-didehydro-2 ',3 '-dideoxyguanosine (d4G) and 2 ',3 '-dideoxyguanosine (ddG) 'ProTide' derivatives. Antiviral Research 74 (3) , 50. 10.1016/j.antiviral.2007.01.063

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Kelleher, MR, Luoni, G and Perrone, P 2007. Application of the phosphoramidate proTide approach to 4‘-Azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside. Journal of Medicinal Chemistry 50 (8) , pp. 1840-1849. 10.1021/jm0613370

Congiatu, C., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2007. Molecular modelling studies on the binding of some protides to the putative human phosphoramidase Hint1. Nucleosides, Nucleotides & Nucleic Acids 26 (8 & 9) , pp. 1121-1124. 10.1080/15257770701521656

Migliore, Marco, Zonta, Nicola, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Henson, G., Andrei, G., Snoeck, R. and Balzarini, J. 2007. Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines. Journal of Medicinal Chemistry 50 (26) , pp. 6485-6492. 10.1021/jm070357e

Perrone, P., Daverio, F., Valente, R., Rajyaguru, S., Martin, J. A., Leveque, V., Le Pogam, S., Najera, I., Klumpp, K., Smith, D. B. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2007. First example of phosphoramidate approach applied to a 4 '-substituted purine nucleoside (4 '-azidoadenosine): Conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus. Journal of Medicinal Chemistry 50 (22) , pp. 5463-5470. 10.1021/jm070362i

Perrone, P., Luoni, G. M., Kelleher, M. R., Daverio, F., Angell, A., Mulready, S., Congiatu, C., Rajyaguru, S., Martin, J. A., Leveque, V., Le Pogam, S., Najera, I., Klumpp, K., Smith, D. B. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2007. Application of the phosphoramidate ProTide approach to 4 '-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside. Journal of Medicinal Chemistry 50 (8) , pp. 1840-1849. 10.1021/jm0613370

Congiatu, Costantino, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2006. Novel potential anticancer naphthyl phosphoramidates of BVdU: Separation of diastereoisomers and assignment of the absolute cConfiguration of the phosphorus center. Journal of Medicinal Chemistry 49 (2) , pp. 452-455. 10.1021/jm0509896

Abdulmajed, Kasem, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2006. Topical delivery of retinyl ascorbate co-drug. 5. in vitro degradation studies. Skin Pharmacology and Physiology 19 (5) , pp. 248-258. 10.1159/000093980

Abdulmajed, Karim, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2005. Topical delivery of retinyl ascorbate co-drug: 6. determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 60 (10) , pp. 794-795.

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Gallagher, Simon John, Congiatu, Costantino, Harwood, John L. ORCID: https://orcid.org/0000-0003-2377-2612, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Nemcova, Marta and Nouskova, Tereza 2005. Preferential π–π complexation between tamoxifen and borage oil/γ linolenic acid: transcutaneous delivery and NMR spectral modulation. International Journal of Pharmaceutics 302 (1-2) , pp. 47-55. 10.1016/j.ijpharm.2005.06.013

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Harris, Sarah Ann, Daluge, Susan M., Gudmundsson, Kristjan S., McLean, Ed W., Burnette, Thimysta C., Marr, Harry, Hazen, Richard, Condreay, Lynn D., Johnson, Lance, De Clercq, Erik and Balzarini, Jan 2005. Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency. Journal of Medicinal Chemistry 48 (10) , pp. 3504-3515. 10.1021/jm0491400

Abdulmajed, Kasem, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2005. Topical delivery of retinyl ascorbate: 4. comparative anti-oxidant activity towards DPPH. Free Radical Research 39 (5) , pp. 491-498. 10.1080/10715760500072263

Abdulmajed, K., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Pugh, William John 2004. Topical delivery of retinyl ascorbate co-drug - 2. Comparative skin tissue and keratin binding studies. Skin Pharmacology and Physiology 17 (6) , pp. 274-282. 10.1159/000081112

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Jarvis, Chris A and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2004. In vitro delivery of novel, highly potent anti-varicella zoster virus nucleoside analogues to their target site in the skin. Pharmaceutical Research 21 (6) , pp. 914-919. 10.1023/B:PHAM.0000029277.60760.43

Griffith, Tudor M., Chaytor, Andrew T., Edwards, David Hughes, Daverio, Felice and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2004. Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine. British Journal of Pharmacology 142 (1) , pp. 27-30. 10.1038/sj.bjp.0705782

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Andrei, E, Pathirana, RN and Snoeck, R 2004. Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: Action via a novel non-nucleosidic mechanism. Journal of Medicinal Chemistry 47 (7) , pp. 1847-1851. 10.1021/jm030857h

Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Kandalaft, L, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Siccardi, D 2003. Stereoselective and concentration-dependent polarised epithelial permeability of a series of phosphoramidate triester prodrugs of d4T: An in-vitro study in Caco-2 and MDCK cell monolayers. Journal of Pharmacology and Experimental Therapeutics 307 (3) , pp. 1112-1119. 10.1124/jpet.103.056135

Jarvis, C. A., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2003. Targeted dermal delivery of highly potent anti-varicella zoster virus nucleoside analogues from saturated solutions and ethanolic oil-in-water creams. Journal of drug targeting 11 (7) , pp. 433-441. 10.1080/1061186042000201990

Jarvis, Chris, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2003. Penetration of highly active anti-VZV nucleoside analogues into and through full-thickness skin. Antiviral Research 57 (3) , A68-A68.

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Jukes, Alison, Blewett, Sally Ann, Barucki, H., Erichsen, Jonathan Thor ORCID: https://orcid.org/0000-0003-1545-9853, Andrei, G., Snoeck, R., De Clercq, E. and Balzarini, J. 2003. Halophenyl furanopyrimidines as potent and selective anti-VZV agents. Antiviral Chemistry & Chemotherapy 14 (3) , pp. 165-170.

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Jukes, Alison, Blewett, Sally, Barucki, Hubert, Erichsen, Jonathan T., Andrei, Graciella, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 2003. Halophenyl furanopyrimidines as potent and selective anti-VZV agents. Antiviral Chemistry and Chemotherapy 14 (3) , pp. 165-170.

Sienaert, R., Naesens, L., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Carangio, A., Andrei, G., Snoeck, R., Van Kuilenburg, A., De Clercq, E., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Balzarini, J. 2003. Metabolic and Pharmacological Characteristics of the Bicyclic Nucleoside Analogues (BCNAs) as Highly Selective Inhibitors of Varicella-Zoster Virus (VZV). Nucleosides, Nucleotides & Nucleic Acids 22 (5-8) , pp. 995-997. 10.1081/NCN-120022721

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 2003. Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity. Bioorganic & Medicinal Chemistry Letters 13 (24) , pp. 4511-4513. 10.1016/j.bmcl.2003.08.028

Sienaert, R., Naesens, L., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, De Clercq, E., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Balzarini, J. 2002. Specific Recognition of the Bicyclic Pyrimidine Nucleoside Analogs, a New Class of Highly Potent and Selective Inhibitors of Varicella-Zoster Virus (VZV), by the VZV-Encoded Thymidine Kinase. Molecular Pharmacology 61 (2) , pp. 249-254. 10.1124/mol.61.2.249

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Blewett, Sally Ann, Siccardi, Dario, Erichsen, Jonathan Thor ORCID: https://orcid.org/0000-0003-1545-9853, Andrei, G., Snoek, R., De Clercq, E. and Blazarini, J. 2002. Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility. Antiviral Chemistry & Chemotherapy 13 (2) , pp. 91-99.

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Blewett, Sally, Siccardi, Dario, Erichsen, Jonathan T., Andrei, Graciella, Snoe, Robert, De Clercq, Erik and Balzarini, Jan 2002. Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility. Antiviral Chemistry and Chemotherapy 13 (2) , pp. 91-99.

Balzarini, J. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2002. Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication. Journal of Antimicrobial Chemotherapy 50 (1) , pp. 5-9. 10.1093/jac/dkf037

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Barucki, H., Srinivasan, S, Jones, G., Pathirana, Ranjith N., Carangio, A., Blewett, S., Luoni, G., Bidet, O., Jukes, A., Jarvis, C., Andrei, G., Snoeck, R., De Clercq, E. and Balzarini, J. 2001. Furano pyrimidines as novel potent and selective anti-VZV agents. Antiviral chemistry & chemotherapy 12 (2) , pp. 77-89.

Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Algain, Berthe, Savy, Pascal, Benhida, Rachid, Fourrey, Jean-Louis, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 2001. Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity. Biorganic and Medicinal Chemistry Letters 11 (18) , pp. 2507-2510. 10.1016/S0960-894X(01)00471-1

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Barucki, H., Blewett, Sally Ann, Carangio, Antonella, Erichsen, Jonathan Thor ORCID: https://orcid.org/0000-0003-1545-9853, Andrei, G., Snoeck, R., De Clercq, E. and Balzarini, J. 2000. Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain. Journal of Medicinal Chemistry 43 (26) , pp. 4993-4997. 10.1021/jm000210m

Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Andrei, G., Snoeck, R., De Clercq, E. and Balzarini, J. 2000. Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain. Bioorganic & Medicinal Chemistry Letters 10 (11) , pp. 1215-1217. 10.1016/S0960-894X(00)00193-1

Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Srinivasan, Subashini, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 2000. Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility. Antiviral Chemistry & Chemotherapy 11 (6) , pp. 383-393.

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Barucki, Hubert, Srinivasan, Subashini, Jones, Garry, Pathirana, Ranjith, Blewett, Sally, Alvarez, Raquel, Yarnold, Christopher J., Carangio, Antonella, Velazquez, Sonsoles, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 2000. Fluorescent bicyclic furo pyrimidine deoxynucleoside analogs as potent and selective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles. Drugs of the Future 25 (11) , pp. 1151-1161.

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Yarnold, Christopher J., Jones, Garry, Velázquez, Sonsoles, Barucki, Hubert, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 1999. Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base. Journal of Medicinal Chemistry 42 (22) , pp. 4479-4484. 10.1021/jm990346o

Balzarini, J., Karlsson, A., Aquaro, S., Perno, C. F., Cahard, D., Naesens, L., De Clercq, E. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 1996. Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives. Proceedings of the National Academy of Sciences 93 (14) , pp. 7295-7299.

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Cahard, Dominique, Sheeka, Hendrika M., De Clercq, Erik and Balzarini, Jan 1996. Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite. Journal of Medicinal Chemistry 39 (8) , pp. 1748-1753. 10.1021/jm950605j