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Number of items: 137.

Ordonez, Liliana D, Hay, Trevor, McEwen, Robert, Polanska, Urszula M, Hughes, Adina, Delpuech, Oona, Cadogan, Elaine, Powell, Steve, Dry, Jonathan, Tornillo, Giusy, Silcock, Lucy, Leo, Elisabetta, O'Connor, Mark J, Clarke, Alan R and Smalley, Matthew J. 2019. Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours. Oncotarget 10 (27) , pp. 2586-2606. 10.18632/oncotarget.26830
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Mohamed, Noha-Ehssan, Hay, Trevor, Reed, Karen R., Smalley, Matthew J. and Clarke, Alan R. 2019. APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression. BMC Cancer 19 , 677. 10.1186/s12885-019-5867-y
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Marshall, Alison, Bradford, Barry M., Clarke, Alan R., Manson, Jean C., Mabbott, Neil A. and Caughey, Byron 2018. Oral prion neuroinvasion occurs independently of PrPC expression in the gut epithelium. Journal of Virology 92 (19) , e01010-18. 10.1128/JVI.01010-18
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Bird, Thomas G., Müller, Miryam, Boulter, Luke, Vincent, David F., Ridgway, Rachel A., Lopez-Guadamillas, Elena, Lu, Wei-Yu, Jamieson, Thomas, Govaere, Olivier, Campbell, Andrew D., Ferreira-Gonzalez, Sofía, Cole, Alicia M., Hay, Trevor, Simpson, Kenneth J., Clark, William, Hedley, Ann, Clarke, Mairi, Gentaz, Pauline, Nixon, Colin, Bryce, Steven, Kiourtis, Christos, Sprangers, Joep, Nibbs, Robert J. B., Van Rooijen, Nico, Bartholin, Laurent, McGreal, Steven R., Apte, Udayan, Barry, Simon T., Iredale, John P., Clarke, Alan R., Serrano, Manuel, Roskams, Tania A., Sansom, Owen J. and Forbes, Stuart J. 2018. TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine 10 (454) , eaan1230. 10.1126/scitranslmed.aan1230

Reed, Karen Ruth, Song, Fei, Young, Madeleine, Hassan, N., Antoine, A. J., Gemici, Nesibe-Princess B, Clarke, Alan Richard and Jenkins, J. R. 2016. Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype. Oncotarget 7 (32) , pp. 51665-51673. 10.18632/oncotarget.10076
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Parry, Lee, Young, Madeleine, El Marjou, Fatima and Clarke, Alan Richard 2015. Protocols for analyzing the role of Paneth cells in regenerating the murine intestine using conditional cre-lox mouse models. Journal of Visualized Experiments (105) , e53429. 10.3791/53429
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Raja, Meera, Zverev, Matthew, Seipel, Katja, Williams, Geraint T., Burnett, Alan Kenneth, Clarke, Alan Richard and Shaw, Paul 2015. Assessment of the in vivo activity of PI3K and MEK inhibitors in genetically defined models of colorectal cancer. Molecular Cancer Therapeutics 14 (10) , pp. 2175-2186. 10.1158/1535-7163.MCT-15-0223

Huels, D. J., Ridgway, R. A., Radulescu, S., Leushacke, M., Campbell, A. D., Biswas, S., Leedham, S., Serra, S., Chetty, R., Moreaux, G., Parry, Lee, Matthews, James, Song, F., Hedley, A., Kalna, G., Ceteci, F., Reed, Karen Ruth, Meniel, Valerie, Maguire, A., Doyle, B., Soderberg, O., Barker, N., Watson, A., Larue, L., Clarke, Alan Richard and Sansom, O. J. 2015. E-cadherin can limit the transforming properties of activating  β‐catenin mutations. EMBO Journal 34 (16) 10.15252/embj.201591739
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Meniel, Valerie, Megges, M., Young, Madeleine, Cole, A., Sansom, O. J. and Clarke, Alan Richard 2015. Apc and p53 interaction in DNA damage and genomic instability in hepatocytes. Oncogene 34 , pp. 4118-4129. 10.1038/onc.2014.342

Lu, Wei-Yu, Bird, Thomas G., Boulter, Luke, Tsuchiya, Atsunori, Cole, Alicia M., Hay, Trevor, Guest, Rachel V., Wojtacha, Davina, Man, Tak Yung, Mackinnon, Alison, Ridgway, Rachel A., Kendall, Timothy, Williams, Michael J., Jamieson, Thomas, Raven, Alex, Hay, David C., Iredale, John P., Clarke, Alan Richard, Sansom, Owen J. and Forbes, Stuart J. 2015. Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nature Cell Biology 17 (8) , pp. 971-983. 10.1038/ncb3203

Tangudu, N. K., Verma, V. K., Clemons, T. D., Beevi, S. S., Hay, Trevor, Mahidhara, G., Raja, Meera, Nair, R. A., Alexander, L. E., Patel, A. B., Jose, J., Smith, N. M., Zdyrko, B., Bourdoncle, A., Luzinov, I., Iyer, K. S., Clarke, Alan Richard and Dinesh Kumar, L. 2015. RNA interference using c-Myc-conjugated nanoparticles suppresses breast and colorectal cancer models. Molecular Cancer Therapeutics 14 (5) , pp. 1259-1269. 10.1158/1535-7163.MCT-14-0970

Reed, Karen Ruth, Athineos, Dimitris, Meniel, Valerie, Wilkins, Julie A., Ridgway, Rachel A., Burke, Zoe D., Muncan, Vanessa, Clarke, Alan Richard and Sansom, Owen J. 2015. Correction for Reed et al., B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 112 (10) , E1168. 10.1073/pnas.1502294112

Reed, Karen Ruth, Korobko, Igor, Ninkina, Natalia, Korobko, Elena V., Hopkins, Ben R., Platt, James L., Buchman, Vladimir and Clarke, Alan Richard 2015. Hunk/Mak-v is a negative regulator of intestinal cell proliferation. BMC Cancer 15 , 110. 10.1186/s12885-015-1087-2
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Koh, D. -I., Han, D., Ryu, H., Choi, W.-I., Jeon, B. -N., Kim, M. -K., Kim, Y., Kim, J. Y., Parry, Lee, Clarke, Alan Richard, Reynolds, A. B. and Hur, M. -W. 2014. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proceedings of the National Academy of Sciences of the United States of America 111 (42) , pp. 15078-15083. 10.1073/pnas.1318780111

Holik, Aliaksei Z., Young, Madeleine, Krzystyniak, Joanna, Williams, Geraint Trefor, Metzger, Daniel, Shorning, Boris and Clarke, Alan Richard 2014. Brg1 loss attenuates aberrant Wnt-signalling and prevents Wnt-dependent tumourigenesis in the murine small intestine. PLoS Genetics 10 (7) , e1004453. 10.1371/journal.pgen.1004453
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Davies, Emma Jane, Marsh Durban, Victoria, Meniel, Valerie, Williams, Geraint Trfor and Clarke, Alan Richard 2014. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. The Journal of Pathology 233 (1) , pp. 27-38. 10.1002/path.4312

Phesse, Toby, Myant, K. B., Cole, A. M., Ridgway, R. A., Pearson, Helen B., Muncan, V., van den Brink, G. R., Vousden, K. H., Sears, R., Vassilev, L . T ., Clarke, Alan Richard and Sansom, Owen J. 2014. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell Death and Differentiation 21 , pp. 956-966. 10.1038/cdd.2014.15
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Khurana, Rimpi, Verma, Vinod, Rawoof, Abdul, Tiwari, Shrish, Nair, Rekha A., Mahidhara, Ganesh, Idris, Mohammed M., Clarke, Alan Richard and Kumar, Lekha 2014. OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer. BMC Bioinformatics 15 (1) , p. 15. 10.1186/1471-2105-15-15
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Marsh Durban, Victoria, Jansen, Marnix, Davies, Emma Jane, Morsink, Folkert H., Offerhaus, G. Johan A. and Clarke, Alan Richard 2014. Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer. American Journal of Pathology 184 (1) , pp. 86-91. 10.1016/j.ajpath.2013.10.003

Holik, Aliaksei, Krzystyniak, Joanna, Young, Madeleine, Richardson, Kirsty, Jarde, Thierry, Chambon, Pierre, Shorning, Boris and Clarke, Alan Richard 2013. Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. Stem Cells 31 (11) , pp. 2457-2466. 10.1002/stem.1498

Hammoudi, Abeer, Song, Fei, Reed, Karen Ruth, Jenkins, Rosalind E., Meniel, Valerie, Watson, Alastair J. M., Pritchard, D. Mark, Clarke, Alan Richard and Jenkins, John R. 2013. Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). Biochemical and Biophysical Research Communications 440 (3) , pp. 364-370. 10.1016/j.bbrc.2013.08.076

Greenow, Kirsty Rhian, Clarke, Alan Richard, Williams, Geraint Trefor and Jones, Robert H. 2013. Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. Oncogene 33 , pp. 4089-4096. 10.1038/onc.2013.371

Marsh Durban, Victoria, Davies, Emma Jane, Williams, Geraint Trefor and Clarke, Alan Richard 2013. PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. The Journal of Pathology 230 (2) , pp. 165-173. 10.1002/path.4189

Parry, Lee, Young, Madeleine, El Marjou, Fatima and Clarke, Alan Richard 2013. Evidence for a crucial role of Paneth Cells in mediating the intestinal response to injury. Stem Cells 31 (4) , pp. 776-785. 10.1002/stem.1326
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Young, Madeleine, Ordonez, Liliana and Clarke, Alan Richard 2013. What are the best routes to effectively model human colorectal cancer? Molecular Oncology 7 (2) , pp. 178-189. 10.1016/j.molonc.2013.02.006

Jarde, Thierry, Evans, Rebecca Jane, McQuillan, Karina, Parry, Lee, Feng, Gui Jie, Alvares, B., Clarke, Alan Richard and Dale, Trevor Clive 2013. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene 32 (7) , pp. 883-893. 10.1038/onc.2012.103

Meniel, Valerie, Song, Fei, Phesse, Toby, Young, Madeleine, Poetz, Oliver, Parry, Lee, Jenkins, John R., Williams, Geraint Trefor, Dunwoodie, Sally L., Watson, Alastair and Clarke, Alan Richard 2013. Cited1 deficiency suppresses intestinal tumorigenesis. PLoS Genetics 9 (8) , e1003638. 10.1371/journal.pgen.1003638
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Feng, Gui Jie, Cotta, Welwyn, Wei, Xiao-Qing, Poetz, Oliver, Evans, Rebecca Jane, Jardé, Thierry, Reed, Karen Ruth, Meniel, Valerie, Williams, Geraint Trefor, Clarke, Alan Richard and Dale, Trevor Clive 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143 (6) , pp. 1650-1659. 10.1053/j.gastro.2012.08.047

Reed, Karen Ruth, Tunster, Simon James, Young, Madeleine, Carrico, Adam Stephen, John, Rosalind Margaret and Clarke, Alan Richard 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61 (10) , pp. 1435-1438. 10.1136/gutjnl-2011-300842

Smartt, Helena J. M., Greenhough, Alexander, Ordonez-Moran, Paloma, Talero, Elena, Cherry, Catherine A., Wallam, Catherine A., Parry, Lee, Al Kharusi, Manal Al, Roberts, Heather R., Mariadason, John M., Clarke, Alan Richard, Huelsken, Joerg, Williams, Ann C. and Paraskeva, Chris 2012. β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut 61 (9) , pp. 1306-1314. 10.1136/gutjnl-2011-300817

Williams, Rebecca, Shorning, Boris, Datta, S., Kynaston, Howard and Clarke, Alan Richard 2012. Development and characterisation of a bladder cancer model [Poster]. BJU International 109 (S7) , p. 25. 10.1111/j.1464-410X.2012.11177.x

Shorning, Boris, Jarde, Thierry, McCarthy, Afshan, Ashworth, Alan, de Leng, Wendy W. J., Offerhaus, George Johan A., Resta, Nicoletta, Dale, Trevor Clive and Clarke, Alan Richard 2012. Intestinal renin-angiotensin system is stimulated after deletion of Lkb1. Gut 61 (2) , pp. 202-213. 10.1136/gutjnl-2011-300046

Greenow, Kirsty Rhian and Clarke, Alan Richard 2012. Controlling the stem cell compartment and regeneration in vivo: the role of pluripotency pathways. Physiological Reviews 92 (1) , pp. 75-99. 10.1152/physrev.00040.2010.

Matthews, James, Sansom, O. J. and Clarke, Alan Richard 2011. Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell Death and Differentiation 18 (12) , pp. 1934-1943. 10.1038/cdd.2011.77

Young, Madeleine and Clarke, Alan Richard 2011. Expanding the p53 toolkit: A new platform for rapid engineering of the p53 locus in vivo [Note]. Cell Cycle 10 (14) , p. 2249. 10.4161/cc.10.14.16205

Parry, Lee and Clarke, Alan Richard 2011. The roles of the methyl-CpG binding proteins in cancer. Genes & Cancer 2 (6) , pp. 618-630. 10.1177/1947601911418499

Shorning, Boris and Clarke, Alan Richard 2011. LKB1 loss of function studied in vivo. FEBS Letters 585 (7) , pp. 958-966. 10.1016/j.febslet.2011.01.019

Davies, Emma Jane, Marsh Durban, Victoria and Clarke, Alan Richard 2011. Origin and maintenance of the intestinal cancer stem cell. Molecular Carcinogenesis 50 (4) , pp. 254-263. 10.1002/mc.20631

Shorning, Boris, Griffiths, David Francis Rees and Clarke, Alan Richard 2011. Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS ONE 6 (1) , e16209. 10.1371/journal.pone.0016209
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Kant, P., Sainsbury, A., Reed, Karen Ruth, Pollard, S. G., Scott, N., Clarke, Alan Richard, Coletta, P. L. and Hull, M. A. 2011. Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB. Gut 60 (7) , pp. 893-901. 10.1136/gut.2010.230755

Thomas, Rhian Sara, Clarke, Alan Richard, Duance, Victor Colin and Blain, Emma Jane 2011. Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Research and Therapy 13 (6) , R203. 10.1186/ar3536
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Shaw, Paul, Maughan, Timothy Stanley and Clarke, Alan Richard 2011. Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apcmin/+ mouse. British Journal of Cancer 105 (5) , pp. 649-657. 10.1038/bjc.2011.291
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Cole, Alicia, Ridgway, Rachel, Derkits, Sahra, Parry, Lee, Barker, Nick, Clevers, Hans, Clarke, Alan Richard and Sansom, Owen 2010. p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Molecular Medicine 2 (11) , pp. 472-486. 10.1002/emmm.201000101

van Dop, Willemijn, Heijmans, Jarom, Büller, Nikè, Snoek, Susanne, Rosekrans, Sanne, Wassenberg, Elisabeth, van den Bergh Weerman, Marius, Lanske, Beate, Clarke, Alan Richard, Winton, Douglas, Wijgerde, Mark, Offerhaus, G. Johan, Hommes, Daan, Hardwick, James, de Jonge, Wouter, Biemond, Izak and van den Brink, Gijs 2010. Loss of Indian hedgehog activates multiple aspects of a wound healing response in the mouse intestine. Gastroenterology 139 (5) , pp. 1665-1676. 10.1053/j.gastro.2010.07.045

Cole, Alicia M., Myant, Kevin, Reed, Karen Ruth, Ridgway, Rachel A., Athineos, Dimitris, Van den Brink, Gijs, Muncan, Vanesa, Clevers, Hans, Clarke, Alan Richard, Sicinski, Peter and Sansom, Owen J. 2010. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Research 70 (20) , pp. 8149-8158. 10.1158/0008-5472.CAN-10-0315

Ashton, Gabrielle H., Morton, Jennifer P., Myant, Kevin, Phesse, Toby, Ridgway, Rachel A., Marsh Durban, Victoria, Wilkins, Julie A., Athineos, Dimitris, Muncan, Vanesa, Kemp, Richard, Neufeld, Kristi, Clevers, Hans, Brunton, Valerie, Winton, Douglas J., Wang, Xiaoyan, Sears, Rosalie C., Clarke, Alan Richard, Frame, Margaret C. and Sansom, Owen J. 2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell 19 (2) , pp. 259-269. 10.1016/j.devcel.2010.07.015

Buchert, Michael, Athineos, Dimitris, Abud, Helen E., Burke, Zoe D., Faux, Maree C., Samuel, Michael S., Jarnicki, Andrew G., Winbanks, Catherine E., Newton, Ian P, Meniel, Valerie, Suzuki, Hiromu, Stacker, Steven A., Näthke, Inke S., Tosh, David, Huelsken, Joerg, Clarke, Alan Richard, Heath, Joan K., Sansom, Owen J. and Ernst, Matthias 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-Catenin pathway in vivo. PLOS Genetics 6 (1) , e1000816. 10.1371/journal.pgen.1000816
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Burke, Zoé D., Reed, Karen Ruth, Phesse, Toby, Sansom, Owen J., Clarke, Alan Richard and Tosh, David 2009. Liver zonation occurs through a β-catenin–dependent, c-Myc–independent mechanism. Gastroenterology 136 (7) , pp. 2316-2324. 10.1053/j.gastro.2009.02.063

Shorning, Boris, Zabkiewicz, Joanna, McCarthy, Afshan, Pearson, Helen B., Winton, Douglas J., Sansom, Owen J., Ashworth, Alam and Clarke, Alan Richard 2009. Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE 4 (1) , e4264. 10.1371/journal.pone.0004264
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Pearson, Helen B., Phesse, Toby and Clarke, Alan Richard 2009. K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Research 69 (1) , pp. 94-101. 10.1158/0008-5472.CAN-08-2895

Barker, Nick, Ridgway, Rachel A., Van Es, Johan H., Van De Wetering, Marc, Begthel, Harry, Van Den Born, Maaike, Danenberg, Esther, Clarke, Alan Richard, Sansom, Owen J. and Clevers, Hans 2009. Crypt stem cells as the cells-of-origin of intestinal cancer [Letter]. Nature 457 (7229) , pp. 608-611. 10.1038/nature07602

Phesse, Toby and Clarke, Alan Richard 2009. Normal stem cells in cancer prone epithelial tissues. British Journal of Cancer 100 (2) , pp. 221-227. 10.1038/sj.bjc.6604850

Greenow, Kirsty Rhian, Clarke, Alan Richard and Jones, Robert H. 2009. Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. Oncogene 28 (11) , pp. 1443-1453. 10.1038/onc.2008.482

Song, F., Phesse, Toby J., Jenkins, J., Clarke, Alan Richard and Watson, A. J. M. 2009. Cited 1 is a novel colorectal cancer gene whose deficiency inhibits the growth of colorectal cancer [Abstract]. Gut 58 (S1) , A3.

Bird, T., Cole, A., Hay, Trevor James, Iredale, J. P., Clarke, Alan Richard, Sansom, O. J. and Forbes, S. J. 2009. A novel inducible genetic murine model of hepatocyte senescence causes a massive hepatic oval cell response and complete hepatocyte replacement from endogenous progenitor cells [Abstract]. Journal of Hepatology 50 (S1) , S3.

Hay, Trevor James, Matthews, J. R., Pietzka, Lucie Charlotte, Lau, A., Cranston, A., Nygren, A. O. H., Douglas-Jones, A., Smith, G. C. M., Martin, N. M. B., O'Connor, M. and Clarke, Alan Richard 2009. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Research 69 (9) , pp. 3850-3855. 10.1158/0008-5472.CAN-08-2388

Reed, Karen Ruth, Athineos, Dimitris, Meniel, Valerie, Wilkins, Julie Ann, Ridgeway, Rachel A., Burke, Zoe D., Muncan, Vanesa, Clarke, Alan Richard and Sansom, Owen J. 2008. B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 105 (48) , pp. 18919-18923. 10.1073/pnas.0805778105

Marsh Durban, Victoria, Winton, Douglas J., Williams, Geraint Trefor, Dubois, Nicole, Trumpp, Andreas, Sansom, Owen J. and Clarke, Alan Richard 2008. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics 40 (12) , pp. 1436-1444. 10.1038/ng.256

Reed, Karen Ruth, Meniel, Valerie, Marsh Durban, Victoria, Cole, Alicia, Sansom, Owen J. and Clarke, Alan Richard 2008. A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 8 , 162. 10.1186/1471-2407-8-162
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Petrova, T. V., Nykanen, A., Norrmen, C., Ivanov, K. I., Andersson, L. C., Haglund, C., Puolakkainen, P., Wempe, F., Melchner, H. von, Gradwohl, G., Vanharanta, S., Aaltonen, L. A., Saharinen, J., Gentile, M., Clarke, Alan Richard, Taipale, J., Oliver, G. and Alitalo, K. 2008. Transcription Factor PROX1 Induces Colon Cancer Progression by Promoting the Transition from Benign to Highly Dysplastic Phenotype. Cancer Cell 13 (5) , pp. 407-419. 10.1016/j.ccr.2008.02.020

Pearson, Helen B., McCarthy, A., Collins, C. M., Ashworth, A. and Clarke, Alan Richard 2008. Lkb1 defiency causes prostate neoplasia in the mouse. Cancer Research 68 (7) , pp. 2223-2232. 10.1158/0008-5472.CAN-07-5169

Phesse, Toby, Parry, Lee, Reed, Karen Ruth, Ewan, Kenneth Burnside Ramsay, Dale, Trevor Clive, Sansom, Owen J. and Clarke, Alan Richard 2008. Deficiency of Mbd2 attenuates Wnt induced tumourigenesis via deregulation of a novel Wnt inhibitor, Lect.2. Molecular and Cellular Biology 28 (19) , pp. 6094-6103. 10.1128/MCB.00539-08

Clarke, Alan Richard 2008. Puma: Mauling the intestinal crypt. Cell Stem Cell 2 (6) , pp. 517-518. 10.1016/j.stem.2008.05.014

Sansom, Owen J., Meniel, Valerie, Muncan, Vanesa, Phesse, Toby, Wilkins, Julie Ann, Reed, Karen Ruth, Vass, Keith, Athineos, Dimitris, Clevers, Hans and Clarke, Alan Richard 2007. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 (7136) , pp. 676-679. 10.1038/nature05674

Marsh Durban, Victoria and Clarke, Alan Richard 2007. Intestinal homeostasis and neoplasia studied using conditional transgenesis. Expert Review of Anticancer Therapy 7 (4) , pp. 519-531. 10.1586/14737140.7.4.519

Kumar, Lekha Dinesh and Clarke, Alan Richard 2007. Gene manipulation through the use of small interfering RNA (siRNA): From in vitro to in vivo applications. Advanced Drug Delivery Reviews 59 (2-3) , pp. 87-100. 10.1016/j.addr.2007.03.009

Sansom, Owen J., Mansergh, Fiona Catherine, Evans, Martin John, Wilkins, Julie and Clarke, Alan Richard 2007. Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Gut 56 , pp. 1410-1414. 10.1136/gut.2006.116921

Dikovskaya, Dina, Schiffmann, David, Newton, Ian P., Oakley, Abigail, Kroboth, Karin, Sansom, Owen J., Jamieson, Thomas J., Meniel, Valerie, Clarke, Alan Richard and Nathke, Inke S. 2007. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. Journal of cell biology 176 (2) , pp. 183-195. 10.1083/jcb.200610099

Dikovskaya, Dina, Schiffmann, David, Newton, Ian P., Oakley, Abigail, Kroboth, Karin, Sansom, Owen J., Jamieson, Thomas J., Meniel, Valerie, Clarke, Alan Richard and Nathke, Inke S. 2007. Correction 176, p. 183. Journal of cell biology 176 (3) , p. 369. 10.1083/jcb.20061009920070116c

Matthews, James, Watson, Susan M. R., Tevendale, Maxine C. L., Watson, Christine J. and Clarke, Alan Richard 2007. Caspase-dependent proteolytic cleavage of STAT3a in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines. BMC Cancer 7 (29) , pp. 1-12. 10.1186/1471-2407-7-29
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Clarke, Alan Richard and Meniel, Valerie 2007. The intestinal stem cell niche studied through conditional transgenesis. Presented at: The Cancer Stem Cell Workshop, Berlin, Germany, November 15- 17 2006. Published in: Wiestler, O. D., Haendler, B. and Mumberg, D. eds. Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy. Ernst Schering Foundation Symposium Proceedings Berlin: Springer, pp. 99-108. 10.1007/2789_2007_046

Clarke, Alan Richard 2007. Cancer genetics: mouse models of intestinal cancer. Biochemical Society Transactions 35 (5) , pp. 1338-1341. 10.1042/BST0351338

Clarke, Alan Richard, Jones, N., Pryde, F., Adachi, Y. and Sansom, O. J. 2007. 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene 26 (43) , pp. 6349-6355. 10.1038/sj.onc.1210457

Berger, J., Sansom, Owen, Clarke, Alan Richard and Bird, A. 2007. MBD2 is required for correct spatial gene expression in the gut. Molecular and Cellular Biology 27 (11) , pp. 4049-4057. 10.1128/MCB.02023-06

Sansom, Owen J., Maddison, Kathryn and Clarke, Alan Richard 2007. Mechanisms of Disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nature Clinical Practice Oncology 4 (5) , pp. 305-315. 10.1038/ncponc0812

Shaw, Paul and Clarke, Alan Richard 2007. Murine models of intestinal cancer: Recent advances. DNA Repair 6 (10) , pp. 1403-1412. 10.1016/j.dnarep.2007.02.022

Clarke, Alan Richard 2006. Wnt signalling in the mouse intestine. Oncogene 25 (57) , pp. 7512-7521. 10.1038/sj.onc.1210065

Sansom, Owen J., Meniel, Valerie, Wilkins, Julie Ann, Cole, Alicia M., Oien, Karin A., Marsh Durban, Victoria, Jamieson, Thomas J., Guerra, Carmen, Ashton, Gabrielle H., Barbacid, Mariano and Clarke, Alan Richard 2006. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences 103 (38) , pp. 14122-14127. 10.1073/pnas.0604130103

Prokhortchouk, Anna, Sansom, Owen J., Selfridge, Jim, Caballero, Isabel M., Salozhin, Sergey, Aithozhina, Dana, Cerchietti, Leandro, Meng, Fan Guo, Augenlicht, Leonard H., Mariadason, John M., Hendrich, Brian, Melnick, Ari, Prokhortchouk, Egor, Clarke, Alan Richard and Bird, Adrian 2006. Kaiso-deficient mice show resistance to intestinal cancer. Molecular and Cellular Biology 26 (1) , pp. 199-208. 10.1128/MCB.26.1.199-208.2006

Muncan, Vanesa, Sansom, Owen J., Tertoolen, Leon, Phesse, Toby, Begthel, Harry, Sancho, Elena, Cole, Alicia M., Gregorieff, Alex, de Alboran, Ignacio Moreno, Clevers, Hans and Clarke, Alan Richard 2006. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Molecular and Cellular Biology 26 (22) , pp. 8418-8426. 10.1128/MCB.00821-06
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Hay, T., Jenkins, H., Sansom, O. J., Martin, N. M. B., Smith, G. C. M. and Clarke, Alan Richard 2006. Brca2 deficiency sensitizes cells to PARP inhibition [Correction to Hay et al. 65 (22): 10145]. Cancer Research 66 (1) , p. 599. 10.1158/0008-5472.CAN-66-1-COR

Stark, Lesley A., Reid, Kirsten, Sansom, Owen J., Din, Farhat V., Guichard, Sylvie, Mayer, Iain, Jodrell, Duncan I., Clarke, Alan Richard and Dunlop, Malcolm G. 2006. Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 28 (5) , pp. 968-976. 10.1093/carcin/bgl220

Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Peters, Jefferey M. and Clarke, Alan Richard 2006. PPARδ status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer 6 (113) 10.1186/1471-2407-6-113
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Sansom, Owen J., Griffiths, David Francis Rees, Reed, Karen Ruth, Winton, Douglas J. and Clarke, Alan Richard 2005. Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene 24 , pp. 8205-8210. 10.1038/sj.onc.1208956

Naylor, Matthew J., Li, Na, Cheung, Julia, Lowe, Emma T., Lambert, Elise, Marlow, Rebecca, Wang, Pengbo, Schatzmann, Franziska, Wintermantel, Timothy, Schüetz, Günther, Clarke, Alan Richard, Mueller, Ulrich, Hynes, Nancy E. and Streuli, Charles H. 2005. Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. Journal of cell biology 171 (4) , pp. 717-728. 10.1083/jcb.200503144

Naylor, M. J., Li, N., Cheung, J., Lowe, E. T., Lambert, E., Wang, P., Marlow, R., Schatzmann, F., Wintermantel, T., Schueetz, G., Clarke, Alan Richard, Dedhar, S., Grant, S. G. N., Mueller, U., Hynes, N. E. and Streuli, C. H. 2005. Ablation of beta 1 integrin, focal adhesion kinase and integrin linked kinase in mammary epithelium reveals a critical role for integrin in glandular morphogenesis and differentiation [Abstract]. Mechanisms of Development 122 (Sup.1) , S96. 10.1016/j.mod.2005.06.010

Meniel, Valerie, Hay, Trevor, Douglas-Jones, Anthony Gordon, Sansom, Owen J. and Clarke, Alan R. 2005. Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Research 65 (24) , pp. 410-6.

Maddison, Kathryn and Clarke, Alan Richard 2005. New approaches for modelling cancer mechanisms in the mouse. The Journal of Pathology 205 (2) , pp. 181-193. 10.1002/path.1698

Matthews, James and Clarke, Alan Richard 2005. p53 mediates a default programme of mammary gland involution in the absence of STAT3. Oncogene 24 (19) , pp. 3083-3090. 10.1038/sj.onc.1208512

Hay, Trevor, Jenkins, Helen, Sansom, Owen J, Martin, Niall M. B., Smith, Graeme C. M. and Clarke, Alan Richard 2005. Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Research 65 (22) , p. 10145. 10.1158/0008-5472.CAN-05-1186

Sansom, Owen J., Reed, Karen Ruth, van de Wetering, M., Muncan, V., Winton, D. J., Clevers, H. and Clarke, Alan Richard 2005. Cyclin D1 is not an immediate target of β-Catenin following Apc loss in the intestine. Journal of Biological Chemistry 280 (31) , pp. 28463-28467. 10.1074/jbc.M500191200

Clarke, Alan Richard and Hay, Trevor 2005. DNA damage hypersensitivity in cells lacking BRCA2: a review of in vitro and in vivo data. Biochemical Society Transactions 33 (4) , pp. 715-717. 10.1042/BST0330715

Clarke, Alan Richard 2005. Studying the consequences of immediate loss of gene function in the intestine: APC. Biochemical Society Transactions 33 (4) , pp. 665-666. 10.1042/BST0330665

Hay, Trevor, Patrick, Teresa, Winton, Douglas, Sansom, Owen J. and Clarke, Alan Richard 2005. Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene 24 (23) , pp. 3842-3846. 10.1038/sj.onc.1208533

Sansom, Owen J., Bishop, Stefan Mark, Bird, Adrian and Clarke, Alan Richard 2005. MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene 24 (14) , pp. 2430-2432. 10.1038/sj.onc.1208166

Zabkiewicz, Joanna and Clarke, Alan Richard 2004. DNA damage-induced apoptosis: insights from the mouse. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1705 (1) , pp. 17-25. 10.1016/j.bbcan.2004.09.002

Tuzi, Nadia L., Clarke, Alan Richard, Bradford, Barry, Aitchison, Lorraine, Thomson, Val and Manson, Jean C. 2004. Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases. genesis 40 (1) , pp. 1-6. 10.1002/gene.20046

Sansom, Owen J., Reed, Karen, Hayes, Anthony Joseph, Ireland, Heather, Brinkmann, Hannah, Newton, Ian P., Batlle, Edouard, Simon-Assmann, Patricia, Clevers, Hans, Nathke, Inke S, Clarke, Alan Richard and Winton, Douglas J. 2004. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes and Development 18 (12) , pp. 1385-1390. 10.1101/gad.287404
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Ireland, Heather, Kemp, Richard, Houghton, Carol, Howard, Louise, Clarke, Alan Richard, Sansom, Owen J. and Winton, Douglas J. 2004. Inducible cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin. Gastroenterology 126 (5) , pp. 1236-1246. 10.1053/j.gastro.2004.03.020

Marquez, Nuria, Chappell, Sally Claire, Sansom, Owen J., Clarke, Alan Richard, Teesdale-Spittle, Paul, Errington, Rachel Jane and Smith, Paul James 2004. Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts. Cell Cycle 3 , pp. 662-671.

Sansom, Owen J., Bishop, Stefan Mark, Bird, Adrian and Clarke, Alan Richard 2004. MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene 23 (33) , pp. 5693-5696. 10.1038/sj.onc.1207767

Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Winton, Douglas J., Peters, Jeffrey M. and Clarke, Alan Richard 2004. PPARδ status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene 23 (55) , pp. 8992-8996. 10.1038/sj.onc.1208143

Marquez, Nuria, Chappell, Sally Claire, Sansom, Owen J., Clarke, Alan Richard, Errington, Rachel Jane, Smith, Paul James and Court, Jonathan 2003. Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint. Oncogene 22 (48) , pp. 7642-7648. 10.1038/sj.onc.1206876

Meniel, Valerie and Clarke, Alan Richard 2003. Wnt-Cadherin connections in normal and neoplastic mammary epithelium. Journal of Mammary Gland Biology and Neoplasia 8 (4) , pp. 435-447. 10.1023/B:JOMG.0000017430.12210.37

Sansom, Owen J., Bishop, Stefan Mark, Court, Helen, Dudley, Sandra, Liskay, R. Michael and Clarke, Alan Richard 2003. Apoptosis and mutation in the murine small intestine: loss of MIh1- and Pms2-dependent apoptosis leads to increased mutation in vivo. DNA Repair 2 (9) , pp. 1029-1039. 10.1016/S1568-7864(03)00111-3

Menke, Aswin L., IJpenberg, Annemieke, Fleming, Stewart, Ross, Allyson, Medine, Claire N., Patek, Charles E., Spraggon, Lee, Hughes, Jeremy, Clarke, Alan Richard and Hastie, Nicholas D. 2003. Thewt1-heterozygous mouse; a model to study the development of glomerular sclerosis. The Journal of Pathology 200 (5) , pp. 667-674. 10.1002/path.1390

Screaton, Robert A., Kiessling, Stephan, Sansom, Owen J., Millar, Catherine B., Maddison, Kathryn, Bird, Adrian, Clarke, Alan Richard and Frisch, Steven M. 2003. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis. Proceedings of the National Academy of Sciences of the United States of America 100 (9) , pp. 5211-5216. 10.1073/pnas.0431215100

Sansom, Owen J., Berger, Jennifer, Bishop, Stefan Mark, Hendrich, Brian, Bird, Adrian and Clarke, Alan Richard 2003. Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nature Genetics 34 (2) , pp. 145-147. 10.1038/ng1155

Domínguez-Bendala, Juan, Priddle, Helen, Clarke, Alan Richard and McWhir, Jim 2003. Elevated expression of exogenous Rad51 leads to identical increases in gene-targeting frequency in murine embryonic stem (ES) cells with both functional and dysfunctional p53 genes. Experimental Cell Research 286 (2) , pp. 298-307. 10.1016/S0014-4827(03)00111-3

Perkins, S., Clarke, Alan Richard, Steward, W. and Gescher, A. 2003. Age-related difference in susceptibility of ApcMin/+ mice towards the chemopreventive efficacy of dietary aspirin and curcumin. British Journal of Cancer 88 (9) , pp. 1480-1483. 10.1038/sj.bjc.6600900

Clarke, Alan Richard and Hollstein, M. 2003. Mouse models with modified p53 sequences to study cancer and ageing [Review]. Cell Death and Differentiation 10 (4) , pp. 443-450. 10.1038/sj.cdd.4401188

Sansom, Owen J., Zabkiewicz, Joanna, Bishop, Stefan Mark, Guy, Jackie, Bird, Adrian and Clarke, Alan Richard 2003. MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene 22 (46) , pp. 7130-7136. 10.1038/sj.onc.1206850

Armit, Christopher, O'Dea, Shirley, Clarke, Alan Richard and Harrison, David John 2002. Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest. BMC Cell Biology 3 (27) 10.1186/1471-2121-3-27
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Menke, Aswin, Clarke, Alan Richard, Leitch, Andrea, Ijpenberg, Annemieke, Williamson, Kathy, Spraggon, Lee, Harrison, David James and Hastie, Nicholas 2002. Genetic interactions between the Wilms’ Tumor 1 Gene and the p53 Gene. Cancer Research 62 (22) , pp. 6615-6620.

Menke, Aswin L., Clarke, Alan Richard, Leitch, Andrea, Ijpenberg, Annemeike, Williamson, Kathy A., Spraggon, Lee, Harrison, David J. and Hastie, Nicholas D. 2002. Genetic interactions between the Wilms' tumor 1 gene and the p53 gene. Cancer Research 62 (22) , pp. 6615-6620.

Gallagher, Ronald C. J., Hay, Trevor, Meniel, Valerie, Naughton, Catherine, Anderson, Thomas J., Shibata, Hiroyuki, Ito, Masaki, Clevers, Hans, Noda, Tetsuo, Sansom, Owen J., Mason, John O. and Clarke, Alan Richard 2002. Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene 21 (42) , pp. 6446-6457. 10.1038/sj.onc.1205892

Toft, Neil J., Curtis, Lucy J., Sansom, Owen J., Leitch, Andrea L., Wyllie, Andrew H., te Riele, Hein, Arends, Mark J. and Clarke, Alan Richard 2002. Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background. Oncogene 21 (41) , pp. 6299-6306. 10.1038/sj.onc.1205727

Sansom, Owen J. and Clarke, Alan Richard 2002. The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice. Oncogene 21 (38) , pp. 5934-5939. 10.1038/sj.onc.1205760

Millar, Catherine B., Guy, Jacky, Sansom, Owen J., Selfridge, Jim, MacDougall, Eilidh, Hendrich, Brian, Keightley,, Peter D., Bishop, Stefan Mark, Clarke, Alan Richard and Bird, Adrian 2002. Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice. Science , pp. 403-405. 10.1126/science.1073354

Cullingworth, Jan, Hooper, Martin L., Harrison, David J., Mason, John O., Sirard, Christian, Patek, Charles E. and Clarke, Alan Richard 2002. Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes. Oncogene 21 (30) , pp. 4696-4701. 10.1038/sj.onc.1205673

Harper, M. J. and Clarke, Alan Richard 2002. Low frequency ultrasonic propagation through fibre reinforced, polymer composites. Ultrasonics 40 (1-8) , pp. 555-560. 10.1016/S0041-624X(02)00169-5

Coe, Jonathan P, Rahman, Irfan, Sphyris, Nathalie, Clarke, Alan Richard and Harrison, David J. 2002. Glutathione and p53 independently mediate responses against oxidative stress in ES cells. Free Radical Biology and Medicine 32 (2) , pp. 187-196. 10.1016/S0891-5849(01)00792-4

Guo, Jian-Kan, Menke, Aswin, Gubler, Marie-Claire, Clarke, Alan Richard, Harrison, David John, Hammes, Annette, Hastie, Nicholas and Schedl, Andreas 2002. WT1 is a key regulator of podocyte function: Reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Human Molecular Genetics 11 (6) , pp. 651-659. 10.1093/hmg/11.6.651

Sansom, Owen J., Stark, Lesley, Dunlop, Malcolm and Clarke, Alan Richard 2001. Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in ApcMin/+ and ApcMin/+, Msh2−/− mice. Cancer Research 61 , pp. 7060-7064.

Sansom, Owen J., Stark, Lesley A., Dunlop, Malcolm G. and Clarke, Alan Richard 2001. Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in ApcMin/+ and ApcMin/+, Msh2-/- mice. Cancer Research 61 , pp. 7060-7064.

Sansom, Owen J., Toft, Neil J., Winton, Douglas J. and Clarke, Alan Richard 2001. Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. Oncogene 20 (27) , pp. 3580-3584. 10.1038/sj.onc.1204449

Strathdee, Gordon, Sansom, Owen J., Sim, Alyson, Clarke, Alan Richard and Brown, Robert 2001. A role for mismatch repair in control of DNA ploidy following DNA damage. Oncogene 20 (15) , pp. 1923-1927. 10.1038/sj.onc.1204276

Clarke, Alan Richard and Sansom, Owen J. 2001. Analyzing tumor suppressor activities in the murine small intestine. Oncology Research 13 (6-10) , pp. 333-337. 10.3727/096504003108748537

Chapman, Rachel S., Duff, Eleanor K., Lourenco, Paula C., Tonner, Elizabeth, Flint, David J., Clarke, Alan Richard and Watson, Christine J. 2000. A novel role for IRF-1 as a suppressor of apoptosis. Oncogene 19 (54) , pp. 6386-6391. 10.1038/sj.onc.1204016

MacKenzie, Alasdair, Payne, Catherine, Boyle, Shelagh, Clarke, Alan Richard and Quinn, John P. 2000. The human preprotachykinin-A gene promoter has been highly conserved and can drive human-like marker gene expression in the adult mouse CNS. Molecular and Cellular Neuroscience 16 (5) , pp. 620-630. 10.1006/mcne.2000.0902

Sansom, Owen J. and Clarke, Alan Richard 2000. P53 null mice: damaging the hypothesis? Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 452 (2) , pp. 149-162. 10.1016/S0027-5107(00)00089-0

Brain, Katherine Emma, Gray, Jonathon, Norman, Paul, France, Elizabeth, Anglim, Cathy, Barton, Garry, Parsons, Evelyn Patricia, Clarke, Alan Richard, Sweetland, Helen Margaret, Tischkowitz, Marc, Myring, Jenny, Stansfield, Kate, Webster, David, Gower-Thomas, Kate, Daoud, Raouf, Gateley, Chris, Montpenny, Ian, Singhal, Hemant, Branston, Lucy, Sampson, Julian Roy, Roberts, Elizabeth, Newcombe, Robert Gordon, Cohen, David, Rogers, Cerilan, Mansel, Robert Edward and Harper, Peter Stanley 2000. Randomized trial of a specialist genetic assessment service for familial breast cancer. Journal of the National Cancer Institute 92 (16) , pp. 1345-1351. 10.1093/jnci/92.16.1345

Nunez, Fatima, Chipchase, Michael D., Clarke, Alan Richard and Melton, David W. 2000. Nucleotide excision repair gene (ERCC1) deficiency causes G2 arrest in hepatocytes and a reduction in liver binucleation: The role of p53 and p21. Faseb Journal 14 (9) , pp. 1073-1082.

Toft, Neil J., Sansom, Owen J., Brookes, Roger A., Arends, Mark J., Wood, Michelle, Margison, Geoffrey P., Winton, Douglas J. and Clarke, Alan Richard 2000. In vivo administration of O6-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine. Carcinogenesis 21 (4) , pp. 593-598.

Clarke, Alan Richard 2000. Manipulating the germline: Its impact on the study of carcinogenesis. Carcinogenesis 21 (3) , pp. 435-441. 10.1093/carcin/21.3.435

Chapman, Rachel S., Lourenco, Paula, Tonner, Elizabeth, Flint, David, Selbert, Stefan, Takeda, Kyoshi, Akira, Shizuo, Clarke, Alan Richard and Watson, Christine J. 2000. The role of Stat3 in apoptosis and mammary gland involution. In: Mol, Jan A. and Clegg, Roger A. eds. Biology of the Mammary Gland, Advances in Experimental Medicine and Biology, Kluwer, pp. 129-138. (10.1007/0-306-46832-8_16)

Clarke, Alan Richard 2000. Controlling apoptosis: implications for carcinogenesis? [Abstract]. Symposia of the Society for Experimental Biology 52 , pp. 265-275.

This list was generated on Fri Dec 13 08:32:26 2019 GMT.