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Number of items: 59.

Stanczyk, Paulina J., Seidel, Monika, White, Judith, Viero, Cedric, George, Christopher H., Zissimopoulos, Spyros and Lai, F. Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2018. Association of cardiac myosin-binding protein-C with the ryanodine receptor channel - putative retrograde regulation? Journal of Cell Science 131 (15) , -. 10.1242/jcs.210443
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Williams, Alan J., Thomas, N. Lowri and George, Christopher H. 2018. The ryanodine receptor: advances in structure and organization. Current Opinion in Physiology 1 , pp. 1-6. 10.1016/j.cophys.2017.10.003
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Benson, Matthew A., Tinsley, Caroline L., Waite, Adrian, Carlisle, Francesca ORCID: https://orcid.org/0000-0002-9734-113X, Sweet, Steve M. M., Ehler, Elisabeth, George, Christopher, Lai, Francis ORCID: https://orcid.org/0000-0003-2852-8547, Martin-Rendon, Enca and Blake, Derek ORCID: https://orcid.org/0000-0002-5005-4731 2017. Ryanodine receptors are part of the myospryn complex in cardiac muscle. Scientific Reports 7 (1) , 6312. 10.1038/s41598-017-06395-6
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Dhanjal, Tarvinder S., Lellouche, Nicolas, Von Ruhland, Christopher, Abehsira, Guillaume, Edwards, David H., Dubois-Randé, Jean-Luc, Moschonas, Konstantinos, Teiger, Emmanuel, Williams, Alan J. and George, Christopher H. 2017. Massive accumulation of myofibroblasts in the critical isthmus is associated with ventricular tachycardia inducibility in post-infarct swine heart. Journal of the American College of Cardiology: Clinical Electrophysiology 3 (7) , pp. 703-714. 10.1016/j.jacep.2016.11.010
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Bannister, Mark, Thomas, N. Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Markus, Sikkel, Mukherjee, Saptarshi, Chloe, Maxwell, Kenneth, MacLeod and George, Christopher H. 2016. Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia [Letter]. The Journal of Physiology 594 (21) , pp. 6431-6432. 10.1113/JP272497
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George, Christopher, Mitchell, Alice N., Preece, Ryan, Bannister, Mark and Yousef, Zaheer 2016. Pleiotropic mechanisms of action of perhexiline in heart failure. Expert Opinion on Therapeutic Patents 26 (9) , pp. 1049-1059. 10.1080/13543776.2016.1211111
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Bannister, Mark L., Alvarez-Laviada, Anita, Thomas, N. Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Mason, Sammy A., Coleman, Sharon, du Plessis, Christo L., Moran, Abbygail T., Neill-Hall, David, Osman, Hasnah, Bagley, Mark C., MacLeod, Kenneth T., George, Christopher H. and Williams, Alan J. 2016. Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. British Journal of Pharmacology 173 (15) , pp. 2446-2459. 10.1111/bph.13521
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Dhanjal, Tarvinder, Lellouche, Nicolas, Von Ruhland, Christopher John, Edwards, David Hughes, George, Christopher and Williams, Alan 2016. LAVA sites are histologically closely related to critical isthmus sites in post-infarct ventricular tachycardia. Presented at: Heart Rhythm 2016 - 37th Annual Scientific Sessions, San Francisco, CA, USA, 4 May 2016.
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Jones, Aled R., Edwards, David Hughes, Cummins, Michael J., Williams, Alan John and George, Christopher H. 2016. A systematized approach to investigate Ca2+ synchronization in iPSC-derived cardiomyocyte networks. Biophysical Journal 110 (3) , 435a. 10.1016/j.bpj.2015.11.2346

Jones, Aled, Edwards, David Hughes, Cummins, Michael J., Williams, Alan John and George, Christopher H. 2016. A systemized approach to investigate Ca2+ synchronization in clusters of human induced pluripotent stem-cell derived cardiomyocytes. Frontiers in Cell and Developmental Biology 3 , 89. 10.3389/fcell.2015.00089
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Dhanjal, Tarvinder, Lellouche, Nicolas, Von Ruhland, Christopher, Edwards, David, George, Christopher and Williams, Alan 2016. Increased myofibroblast densities are specific to critical isthmus sites in post-infarct re-entrant ventricular tachycardia. Presented at: Heart Rhythm Society, San Francisco, May 2016.
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George, Christopher H. and Edwards, David H. 2016. Decoding Ca2+ signals as a non-electrophysiological method for assessing drug toxicity in stem cell-derived cardiomyocytes. Clements, Michael and Roquemore, Elizabeth P., eds. Stem Cell-derived models in Toxicology, Springer,
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Boileau, Etienne, George, Christopher H., Parthimos, Dimitris ORCID: https://orcid.org/0000-0003-3852-323X, Mitchell, Alice N., Aziz, Sabina and Nithiarasu, Perumal 2015. Synergy between intercellular communication and intracellular Ca2+ handling in arrhythmogenesis. Annals of Biomedical Engineering 43 , pp. 1614-1625. 10.1007/s10439-014-1243-x
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Bannister, Mark L., Thomas, N. Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Sikkel, Markus B., Mukherjee, Saptarshi, Maxwell, Chloe, MacLeod, Kenneth T., George, Christopher H. and Williams, Alan J. 2015. The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2. Circulation Research 116 (8) , pp. 1324-1335. 10.1161/CIRCRESAHA.116.305347

Lewis, Kimberley, Silvester, Nicole C., Barberini-Jammaers, Steven, Mason, Sammy, Marsh, Sarah A., Lipka, Magdalena and George, Christopher 2015. A new system for profiling drug-induced calcium signal perturbation in human embryonic stem cell-derived cardiomyocytes. Journal of Biomolecular Screening 20 (3) , pp. 330-340. 10.1177/1087057114557232
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George, Christopher, Parthimos, Dimitris ORCID: https://orcid.org/0000-0003-3852-323X and Silvester, Nicole C. 2012. A network-oriented perspective on cardiac calcium signaling. American Journal of Physiology - Cell Physiology 303 (9) , C897-C910. 10.1152/ajpcell.00388.2011

Viero, Cedric, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Euden, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Mason, Sammy A., George, Christopher H. and Williams, Alan J. 2012. Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level. Calcium Signaling, Advances in Experimental and Medical Biology, Dordrecht: Springer, pp. 183-215. (10.1007/978-94-007-2888-2_8)

Viero, Cedric, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Euden, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Mason, Sammy, George, Christopher H. and Williams, Alan John 2012. Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level. Islam, Md. Shahidul, ed. Calcium Signaling, Advances in Experimental Medicine and Biology, vol. 740. Dordrecht: Springer, pp. 183-215. (10.1007/978-94-007-2888-2_8)

Silvester, Nicole C. and George, Christopher H. 2011. Searching for new cardiovascular drugs: towards improved systems for drug screening? Expert Opinion on Drug Discovery 6 (11) , pp. 1155-1170. 10.1517/17460441.2011.625652
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Phillips, Sally Victoria, Yu, Yuansong, Rossbach, Andreas Michael ORCID: https://orcid.org/0000-0002-6041-7348, Nomikos, Michail ORCID: https://orcid.org/0000-0001-9761-6327, Vassilakopoulou, Vyronia, Livaniou, Evangelia, Cumbes, Bevan ORCID: https://orcid.org/0000-0001-8529-0040, Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547, George, Christopher H. and Swann, Karl ORCID: https://orcid.org/0000-0002-4355-1449 2011. Divergent effect of mammalian PLC-zeta in generating Ca2+ oscillations in somatic cells versus eggs. Biochemical Journal 438 , pp. 545-533. 10.1042/BJ20101581

Eisner, D. A., George, Christopher H., Smith, G. L., Trafford, A. W. and Venetucci, L. A. 2010. How does CaMKII phosphorylation of the cardiac ryanodine receptor contribute to inotropy? [Letter]. Proceedings of the National Academy of Sciences of the United States of America 107 (31) , E123. 10.1073/pnas.1008809107

Raby, Anne-Catherine ORCID: https://orcid.org/0000-0002-5354-5835, Le Bouder, Emmanuel, Colmont, Chantal Sophie, Davies, James Anthony ORCID: https://orcid.org/0000-0003-3569-4500, Richards, Peter, Coles, Barbara, George, Christopher H., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Topley, Nicholas and Labeta, Mario Oscar ORCID: https://orcid.org/0000-0001-5750-6983 2009. Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering. The Journal of Immunology 183 (1) , pp. 506-517. 10.4049/jimmunol.0802909

Burley, Dwaine, George, Christopher, Wann, Kenneth Taylor and Baxter, Gary ORCID: https://orcid.org/0000-0002-7887-6841 2008. Evidence for serca and BKCa activation in BNP protection of reperfused myocardium [Abstract]. Journal of Molecular and Cellular Cardiology 44 (4) , p. 717. 10.1016/j.yjmcc.2008.02.015

George, Christopher H., Barberini-Jammaers, Steven Roger and Müller, Carsten Theodor ORCID: https://orcid.org/0000-0003-0455-7132 2008. Refocussing therapeutic strategies for cardiac arrhythmias: defining viable molecular targets to restore cardiac ion flux drug. Expert Opinion on Therapeutic Patents 18 (1) , pp. 1-19. 10.1517/13543776.18.1.1

George, Christopher H. 2008. Genetic polymorphisms in β1 and β2 adrenergic receptors: variations without a theme? Heart Rhythm 5 (6) , pp. 822-825. 10.1016/j.hrthm.2008.03.034

George, Christopher H., Rogers, Sarah Ann, Bertrand, Benedicte M.A., Tunwell, Richard E.A., Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Steele, Derek S., Cox, Eryl Vanessa, Pepper, Christopher John, Hazeel, Carolyn Jean, Claycomb, William C. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2007. Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signalling and susceptibility to apoptosis. Circulation Research 100 (6) , pp. 874-883. 10.1161/01.RES.0000260804.77807.cf

George, Christopher H., Jundi, Hala, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Fry, Debra L. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2007. Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies. Journal of Molecular and Cellular Cardiology 42 (1) , pp. 34-50. 10.1016/j.yjmcc.2006.08.115

Jundi, Hala, Lai, F. A. and George, Christopher H. 2007. Targeting the RyR2 I-domain as a novel strategy to correct mutationlinked Ca2+ release channel dysfunction. Biophysical Journal , 262A-262A.

Fry, Debra, Jundi, Hala, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 and George, Christopher H. 2007. Modulating intracellular Ca2+ signaling using recombinant fragments of the human cardiac ryanodine receptor (RyR2). Biophysical Journal , 260A-260A.

George, Christopher H 2007. Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance? Cardiovascular Research 77 (2) , pp. 302-314. 10.1093/cvr/cvm006

George, Christopher H., Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Williams, A. J. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2007. Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction. Biochemical Society Transactions 35 (5) , pp. 946-951. 10.1042/BST0350946

George, Christopher and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2007. Developing new anti-arrhythmics: clues from the molecular basis of cardiac ryanodine receptor (RyR2) Ca2+-release channel dysfunction. Current Pharmaceutical Design 13 (31) , pp. 3195-3211. 10.2174/138161207782341259

George, Christopher H. 2006. Ryanodine receptor mutations and ventricular arrhythmias: channel instability at the heart of Ca2+ release dysfunction. Journal of Molecular and Cellular Cardiology 40 (6) , p. 985. 10.1016/j.yjmcc.2006.03.191

George, Christopher H., Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576 and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2006. Role of ryanodine receptor mutations in cardiac pathology: more questions than answers? Biochemical Society Transactions 34 (5) , pp. 913-918. 10.1042/BST0340913

George, Christopher, Jundi, Hala, Walters, Nicola, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, West, Robert Raynard and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2005. Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction. Circulation Research 98 (12) , pp. 88-97. 10.1161/01.RES.0000199296.70534.7c

George, Christopher H., Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576 and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2005. Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death. Future Cardiology 1 (4) , pp. 531-541. 10.2217/14796678.1.4.531

Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 and George, Christopher H. 2005. Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. Biochemical and Biophysical Research Communications 331 (1) , pp. 231-238. 10.1016/j.bbrc.2005.02.194

George, Christopher, Walters, N., Thomas, N. L., Yeung, W. Y., Reynolds, D. F. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2005. Visualisation of intra-RyR2 interactions in HL-1 cardiomyocytes: novel FRET probes reveal a structural basis for Ca2+ channel dysfunction in arrhythmogenesis. Biophysical Journal 88 (1) , 92A-92A.

Thomas, L., George, Christopher H. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2005. In situ characterisation of the Ca2+ sensitivity of cardiac RyR mutations reveals multiple mechanisms of channel dysfunction in sudden death. Biophysical Journal 88 (1) , 308A-309A.

George, Christopher, Yin, Chang Cheng and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2005. Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels. Cell Biochemistry and Biophysics 42 (2) , pp. 197-222. 10.1385/CBB:42:2:197

Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, George, Christopher and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2004. Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death. Cardiovascular Research 64 (1) , pp. 52-60. 10.1016/j.cardiores.2004.06.009

George, Christopher, Jundi, Hala, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Scoote, Mark, Walters, Nicola, Williams, Alan John and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2004. Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. Molecular biology of the cell 15 (6) , pp. 2627-2638. 10.1091/mbc.E03-09-0688
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George, Christopher, Jundi, Hala, Thomas, N. L. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2004. Altered intra-RyR interaction associated with stress-induced ventricular tachycardia. Biophysical Journal 86 (1) , 49A-50A.

Thomas, L., George, Christopher H. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2004. Molecular mechanisms underlying RyR2 (Ca2+ release channel) dysfunction in stress-induced VT. Biophysical Journal 86 (1) , 49A-49A.

George, Christopher H., Higgs, Gemma and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2003. Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circulation Research 93 (6) , pp. 531-540. 10.1161/01.RES.0000091335.07574.86

George, Christopher, Higgs, Gemma, Mackrill, John J. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2003. Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6. Journal of biological chemistry 278 (31) , pp. 28856-28864. 10.1074/jbc.M212440200

George, Christopher, Sorathia, Rina, Bertrand, Benedicte M. A. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2003. In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. Biochemical Journal 370 (2) , pp. 579-589. 10.1042/BJ20021433

George, Christopher and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2003. Transcriptional alterations mediated via dysregulated human cardiac ryanodine receptor (hRyR2). Biophysical Journal 84 (2) , 390A-390A.

Rogers, S. A., George, Christopher, Cox, E. V., Hazeel, C. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2003. Expression of human RyR2 splice variants. Biophysical Journal 84 (2) , 64A-64A.

George, Christopher and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2002. In situ regulation of the human cardiac ryanodine receptor (hRyR2) by intramolecular interaction. Biophysical Journal 82 (1) , 624A-624A.

George, Christopher and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2002. Cytoplasmic Ca2+ spiking via human RyR2 mediates cell death. Biophysical Journal 82 (1) , 61A-61A.

Martin, Patricia E. M., Mambetisaeva, Elvira T., Archer, Deborah A., George, Christopher H. and Evans, William Howard 2000. Analysis of gap junction assembly using mutated connexins detected in Charcot-Marie-Tooth X-linked disease. Journal of Neurochemistry 74 (2) , pp. 711-720. 10.1046/j.1471-4159.2000.740711.x

George, Christopher H., Kendall, J. M. and Evans, William Howard 1999. Intracellular trafficking pathways in the assembly of connexins into gap junctions. Journal of Biological Chemistry 274 (13) , pp. 8678-8685. 10.1074/jbc.274.13.8678

Ahmad, Shoeb, Diez, Juan A., George, Christopher and Evans, William Howard 1999. Synthesis and assembly of connexins in vitro into homomeric and heteromeric functional gap junction hemichannels. Biochemical Journal 339 (2) , pp. 247-2535. 10.1042/0264-6021:3390247

George, Christopher H., Kendall, Jonathan M., Campbell, Anthony Keith and Evans, William Howard 1998. Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cells. Journal of Biological Chemistry 273 (45) , pp. 29822-29829. 10.1074/jbc.273.45.29822

Martin, Patricia E. M., George, Christopher H., Castro, C., Kendall, Jonathan M., Capel, J., Campbell, Anthony Keith, Revilla, A., Barrio, L. C. and Evans, William Howard 1998. Assembly of chimeric connexin-aequorin proteins into functional gap junction channels - Reporting intracellular and plasma membrane calcium environments. Journal of Biological Chemistry 273 (3) , pp. 1719-1726. 10.1074/jbc.273.3.1719

Martin, Patricia E. M., Castro, C., George, Christopher H., Capel, J., Campbell, Anthony Keith, Revilla, A., Barrio, L. C. and Evans, William Howard 1998. Targeting connexin-aequorin chimerae to the gap junction. Presented at: 8th International Gap Junction Conference, Key Largo, FL, USA, 12- 17 July 1997. Published in: Werner, R. ed. Gap Junctions: Proceedings of the 8th International Gap Junction Conference, Key Largo, Florida. Amsterdam: IOS Press, pp. 107-111.

George, Christopher H., Kendall, Jonathan M., Campbell, Anthony Keith, Martin, Patricia E. M. and Evans, William Howard 1998. Reporting the calcium environment in trafficking pathways leading to gap junction biogenesis using connexin-aequorin chimerae. Presented at: 8th International Gap Junction Conference, Key Largo, FL, USA, 12- 17 July 1997. Published in: Werner, R. ed. Gap Junctions: Proceedings of the 8th International Gap Junction Conference, Key Largo, Florida. Amsterdam: IOS Press, pp. 140-144.

George, Christopher H., Martin, P. E. M. and Evans, William Howard 1998. Rapid determination of gap junction formation Using HeLa cells microinjected with cDNAs encoding Wild-Type and chimeric connexins. Biochemical and Biophysical Research Communications 247 (3) , pp. 785-789. 10.1006/bbrc.1998.8835

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