Enhancing the delivery of therapeutic cargo to cancer cells using cell penetrating peptides

Eissa, Noura Gamal 2015. Enhancing the delivery of therapeutic cargo to cancer cells using cell penetrating peptides. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

Cell penetrating peptides (CPPs) have received considerable attention as cellular delivery vectors for small-molecule and macromolecular therapeutics. Hundreds of CPP sequences have now been described including bioportides that serve as single entity modifiers of cell physiology. Translation of promising CPP pre-clinical studies have however been disappointing as few identified delivery-systems have progressed to clinical trials. This project aimed to extend on studies using CPPs for delivering peptides influencing NF-B signalling and to search for novel membrane active peptides that could be classed as CPPs or bioportides.

Item Type:	Thesis (PhD)
Date Type:	Completion
Status:	Unpublished
Schools:	Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Cancer, Cells, Therapeutic cargo, Peptides
Date of First Compliant Deposit:	30 March 2016
Last Modified:	21 Aug 2023 15:27
URI:	https://orca.cardiff.ac.uk/id/eprint/86622

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