Dopamine markers and general cognitive ability

Ball, D., Hill, L., Eley, T. C., Chorney, M. J., Chorney, K., Thompson, L. A., Detterman, D. K., Benbow, C., Lubinski, D., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, McGuffin, P. and Plomin, R. 1998. Dopamine markers and general cognitive ability. NeuroReport 9 (2) , pp. 347-349. 10.1097/00001756-199801260-00031

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Abstract

Because general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0959-4965
Last Modified:	31 Oct 2022 09:37
URI:	https://orca.cardiff.ac.uk/id/eprint/81753

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