Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542, Temperini, Claudia, Gabbiani, Chiara, Supuran, Claudiu T. and Messori, Luigi 2010. The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins. ChemMedChem 5 (12) , pp. 1989-1994. 10.1002/cmdc.201000331 |
Official URL: http://dx.doi.org/10.1002/cmdc.201000331
Abstract
Heavy metals rock! The reactivity of the antimetastatic metallodrug NAMI-A with human carbonic anhydrase II (hCAII) has been investigated using a number of techniques, including X-ray crystallography. The characterization of the interactions between NAMI-A and hCAII provides valuable information on the molecular mechanisms responsible for the activity of this promising anticancer agent.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | Wiley-Blackwell |
ISSN: | 1860-7179 |
Last Modified: | 31 Oct 2022 08:57 |
URI: | https://orca.cardiff.ac.uk/id/eprint/79336 |
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