Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Asymmetric Michael Addition-Lactonization of Carboxylic Acids

Belmessieri, D., Morrill, Louis ORCID: https://orcid.org/0000-0002-6453-7531, Simal, C., Slawin, A. M. Z. and Smith, A. D. 2011. Asymmetric Michael Addition-Lactonization of Carboxylic Acids. Synfacts 2011 (04) , 0436. 10.1055/s-0030-1259622

Full text not available from this repository.

Abstract

A highly efficient asymmetric intra- and intermolecular Michael addition-lactonization of a variety of enone acids, arylacetic acids, and α-keto-β,γ-unsaturated esters using chiral isothioureas as catalysts was reported. The combination of an activating agent and the catalyst was crucial to generate an efficient catalytic cycle. To further demonstrate the utility of this process, the authors performed a simple derivatization of the products to obtain indene carboxylates in good yields and high enantioselectivities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Thieme Publishing
ISSN: 1861-1958
Last Modified: 28 Oct 2022 09:22
URI: https://orca.cardiff.ac.uk/id/eprint/74310

Actions (repository staff only)

Edit Item Edit Item