Correlation between baseline blood pressure and the brainstem FMRI response to isometric forearm contraction in human volunteers: a pilot study

Coulson, James Michael, Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X, Harris, A. D., Fjodorova, Marija, Cockcroft, John Ronald and Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144 2015. Correlation between baseline blood pressure and the brainstem FMRI response to isometric forearm contraction in human volunteers: a pilot study. Journal of Human Hypertension 29 (7) , pp. 449-455. 10.1038/jhh.2014.103

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Abstract

It has been shown previously that changes in brainstem neural activity correlate with changes in both mean arterial pressure (MAP) and muscle sympathetic nerve activity (MSNA) during static handgrip (SHG). However, the relationship between baseline MAP and brainstem neural activity is unclear. We investigated changes in blood oxygen level-dependent (BOLD) signal induced by SHG in 12 young adults using BOLD functional magnetic resonance imaging (FMRI). An estimation of the blood pressure response to SHG was obtained in seven subjects during a session outside the MRI scanner and was used to model the blood pressure response to SHG inside the scanner. SHG at 40% of maximum grip increased MAP (mean±s.d.) at the end of the 180-s squeeze from 85±6 mm Hg to 108 ±15 mm Hg, P=0.0001. The brainstem BOLD signal change associated with SHG was localised to the ventrolateral medulla. This regional BOLD signal change negatively correlated with baseline MAP, r=−0.61, P=0.01. This relationship between baseline MAP and brainstem FMRI responses to forearm contraction is suggestive of a possible role for brainstem activity in the control of MAP and may provide mechanistic insights into neurogenic hypertension.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI) Physics and Astronomy Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information:	Published online 13 November 2014
Publisher:	Nature Publishing Group
ISSN:	0950-9240
Date of Acceptance:	8 October 2014
Last Modified:	15 Nov 2022 11:53
URI:	https://orca.cardiff.ac.uk/id/eprint/72770

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