Relocation, realignment and standardisation: circuits of translation in Huntington’s disease

Lewis, Jamie ORCID: https://orcid.org/0000-0002-1065-6017, Hughes, Jacki and Atkinson, Paul ORCID: https://orcid.org/0000-0001-7367-8160 2014. Relocation, realignment and standardisation: circuits of translation in Huntington’s disease. Social Theory and Health 12 , pp. 396-415. 10.1057/sth.2014.13

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Abstract

Based on complementary ethnographies of a biomedical laboratory and a clinic – both working on Huntington Disease (HD) – we discuss the circuits of translation evident in biomedical and clinical research. By examining a recent epistemological shift from understanding the disease as genetic to understanding the disease as a problem for neuroscience, as well as documenting the multiple framings of the disease that migrate between the laboratory and the clinic, we emphasise the complexity involved in the movement of biomedical science into clinical work. We stress that this is not a one-way flow from the colloquially known bench to bedside, but is dependent on a cluster of contextual activities and local actors. We also stress the extent to which global collaborations, standardisation and regulatory frameworks can facilitate such framing and migration by aligning local practices and different disciplinary outlooks. We take a sociological perspective on translational processes – or rather to an expanded understanding of translation – to capture the material flows and conceptual transformations that are involved in the complex relationships between fundamental and clinical research.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences Social Sciences (Includes Criminology and Education)
Subjects:	H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General)
Publisher:	Palgrave Macmillan
ISSN:	1477-8211
Funders:	ESRC
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 Nov 2023 01:37
URI:	https://orca.cardiff.ac.uk/id/eprint/70543

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