Exploiting the nephrotoxic effects of venom from the sea anemone, phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat

Mizuno, Masashi, Ito, Yasuhiko and Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 2012. Exploiting the nephrotoxic effects of venom from the sea anemone, phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat. Marine Drugs 10 (7) , pp. 1582-1604. 10.3390/md10071582

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (5MB) | Preview

Abstract

In the natural world, there are many creatures with venoms that have interesting and varied activities. Although the sea anemone, a member of the phylum Coelenterata, has venom that it uses to capture and immobilise small fishes and shrimp and for protection from predators, most sea anemones are harmless to man. However, a few species are highly toxic; some have venoms containing neurotoxins, recently suggested as potential immune-modulators for therapeutic application in immune diseases. Phyllodiscus semoni is a highly toxic sea anemone; the venom has multiple effects, including lethality, hemolysis and renal injuries. We previously reported that venom extracted from Phyllodiscus semoni induced acute glomerular endothelial injuries in rats resembling hemolytic uremic syndrome (HUS), accompanied with complement dysregulation in glomeruli and suggested that the model might be useful for analyses of pathology and development of therapeutic approaches in HUS. In this mini-review, we describe in detail the venom-induced acute renal injuries in rat and summarize how the venom of Phyllodiscus semoni could have potential as a tool for analyses of complement activation and therapeutic interventions in HUS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	sea anemone; hemolytic uremic syndrome; complement; complement regulators; marine envenomation; renal failure
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1660-3397/ (accessed 20/02/2014).
Publisher:	MDPI AG
ISSN:	1660-3397
Date of First Compliant Deposit:	30 March 2016
Last Modified:	04 May 2023 20:10
URI:	https://orca.cardiff.ac.uk/id/eprint/43288

Citation Data

Cited 15 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item