Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Compulsive drug use linked to sensitized ventral striatal dopamine transmission

Evans, Andrew H., Pavese, Nicola, Lawrence, Andrew David ORCID: https://orcid.org/0000-0001-6705-2110, Tai, Yen F., Appel, Silke, Doder, Miroslava, Brooks, David J., Lees, Andrew J. and Piccini, Paola 2006. Compulsive drug use linked to sensitized ventral striatal dopamine transmission. Annals of Neurology 59 (5) , pp. 852-858. 10.1002/ana.20822

Full text not available from this repository.

Abstract

Objective A small group of Parkinson's disease (PD) patients compulsively use dopaminergic drugs despite causing harmful social, psychological, and physical effects and fulfil core Diagnostic and Statistical Manual (of Mental Disorders) Fourth Edition criteria for substance dependence (dopamine dysregulation syndrome [DDS]). We aimed to evaluate levodopa-induced dopamine neurotransmission in the striatum of patients with DDS compared with PD control patients. Methods We used a two-scan positron emission tomography protocol to calculate the percentage change in 11C-raclopride binding potential from a baseline withdrawal (off drug) state to the binding potential after an oral dose of levodopa. We related the subjective effects of levodopa to the effects on endogenous dopamine release of a pharmacological challenge with levodopa in eight control PD patients and eight patients with DDS. Results PD patients with DDS exhibited enhanced levodopa-induced ventral striatal dopamine release compared with levodopa-treated patients with PD not compulsively taking dopaminergic drugs. The sensitized ventral striatal dopamine neurotransmission produced by levodopa in these individuals correlated with self-reported compulsive drug “wanting” but not “liking” and was related to heightened psychomotor activation (punding). Interpretation This provides evidence that links sensitization of ventral striatal circuitry in humans to compulsive drug use. Ann Neurol 2006

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
Publisher: Wiley
ISSN: 0364-5134
Last Modified: 20 Oct 2022 09:43
URI: https://orca.cardiff.ac.uk/id/eprint/32927

Citation Data

Cited 347 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item