Mental chronometry of working memory retrieval: a combined functional magnetic resonance imaging and event-related potentials approach

Bledowski, Christoph, Kadoshi, Kathrin Cohen, Wibral, Michael, Rahm, Benny, Bittner, Robert A., Hoechstetter, Karsten, Scherg, Michael, Maurer, Konrad, Goebel, Rainer and Linden, David Edmund Johannes ORCID: https://orcid.org/0000-0002-5638-9292 2006. Mental chronometry of working memory retrieval: a combined functional magnetic resonance imaging and event-related potentials approach. Journal of Neuroscience 26 (3) , pp. 821-829. 10.1523/JNEUROSCI.3542-05.2006

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Abstract

We used the combination of functional magnetic resonance imaging and event-related potentials to decompose the processing stages (mental chronometry) of working memory retrieval. Our results reveal an early transient activation of inferotemporal cortex, which was accompanied by the onset of a sustained activation of posterior parietal cortex. We furthermore observed late transient responses in ventrolateral prefrontal cortex and late sustained activity in medial frontal and premotor areas. We propose that these neural signatures reflect the cognitive stages of task processing, perceptual evaluation (inferotemporal cortex), storage buffer operations (posterior parietal cortex), active retrieval (ventrolateral prefrontal cortex), and action selection (medial frontal and premotor cortex). This is also supported by their differential temporal contribution to specific subcomponents of the P300 cognitive potential.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	working memory; retrieval; EEG; fMRI; source analysis; P300
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.jneurosci.org/site/misc/ifa_policies.xhtml#copyright (accessed 27/02/2014).
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Date of First Compliant Deposit:	30 March 2016
Last Modified:	02 May 2023 21:49
URI:	https://orca.cardiff.ac.uk/id/eprint/32885

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