Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy

Havrylov, Serhiy, Redowicz, Maria Jolanta and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2010. Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy. Traffic 11 (6) , pp. 721-731. 10.1111/j.1600-0854.2010.01061.x

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Abstract

Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle-mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti-cancer therapies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords:	cancer cell invasion; cell adhesion; cell migration; invadopodia; malignancy; Ruk/CIN85; vesicle-mediated transport
Publisher:	Wiley
ISSN:	1398-9219
Last Modified:	19 Oct 2022 10:06
URI:	https://orca.cardiff.ac.uk/id/eprint/23247

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