Neutrophils are important in early control of lung infection by Yersinia pestis

Laws, Thomas R., Davey, Martin S., Titball, Richard W. and Lukaszewski, Roman 2010. Neutrophils are important in early control of lung infection by Yersinia pestis. Microbes And Infection 12 (4) , pp. 331-335. 10.1016/j.micinf.2010.01.007

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Abstract

In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils from naïve BALB/c mice were found to reduce numbers of culturable Yersiniapestis strain GB in suspension. A murine, BALB/c, intranasal model of pneumonic plague was used in conjunction with in vivoneutrophil ablation, using the GR-1 antibody. This treatment reduced neutrophil numbers without affecting other leukocyte numbers. Neutrophil ablated mice exhibited increased bacterial colonisation of the lung 24 h post infection. Furthermore, exposure of Y. pestis to human neutrophils resulted in a 5-fold reduction in the number of viable bacterial cells, whereas, PBMCs had no effect.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Uncontrolled Keywords:	Neutrophil; Yersiniapestis; Innate immunity; Ablation; Intranasal; ex vivo
Publisher:	Elsevier Masson SAS
ISSN:	1286-4579
Last Modified:	19 Mar 2016 22:39
URI:	https://orca.cardiff.ac.uk/id/eprint/23002

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