Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score

Yilmaz, Z. ORCID: https://orcid.org/0000-0003-1967-5270, Renton, T., Yiangou, Y., Zakrzewska, J., Chessell, I.P., Bountra, C. and Anand, P. 2007. Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. Journal of Clinical Neuroscience 14 (9) , pp. 864-871. 10.1016/j.jocn.2006.09.002

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Abstract

Burning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5–5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n = 10) and controls (n = 10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immunostained for TRPV1, NGF, and structural nerve markers neurofilament and peripherin. Nerve fibres penetrating the epithelium were less abundant in BMS (p < 0.0001), indicating a small fibre neuropathy. TRPV1-positive fibres were overall significantly increased in BMS (p = 0.0011), as were NGF fibres (p < 0.0001) and basal epithelial cell NGF staining (p < 0.0147). There was a significant correlation between the baseline pain score and TRPV1 (p = 0.0143) and NGF fibres (p = 0.0252). A significant correlation was observed between baseline and post-capsaicin pain (p = 0.0006). Selective TRPV1 and NGF blockers may provide a new therapy for BMS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0967-5868
Date of Acceptance:	22 September 2006
Last Modified:	24 Oct 2022 07:38
URI:	https://orca.cardiff.ac.uk/id/eprint/115487

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