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CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML

Lucas, Claire M., Scott, Laura J., Carmell, Natasha, Holcroft, Alison K., Hills, Robert K. ORCID: https://orcid.org/0000-0003-0166-0062, Burnett, Alan K. and Clark, Richard E. 2018. CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML. Blood Advances 2 (9) , p. 964. 10.1182/bloodadvances.2017013615

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Abstract

PP2A inhibition occurs in AML by 2 different pathways: CIP2A in normal karyotype patients and SETBP1 in adverse karyotype patients. AKTS473 phosphorylation is a predictor of survival, and diagnostic levels of AKTS473 could be a novel biomarker in AML.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: American Society of Hematology: Blood Advances
ISSN: 2473-9529
Date of First Compliant Deposit: 3 August 2018
Date of Acceptance: 16 March 2018
Last Modified: 05 May 2023 06:43
URI: https://orca.cardiff.ac.uk/id/eprint/113883

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Cited 11 times in Scopus. View in Scopus. Powered By Scopus® Data

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