Wenzel, Margot ORCID: https://orcid.org/0000-0001-6411-1816, Meier-Menches, Samuel, Williams, Thomas, Rämisch, Eberhard, Barone, Giampaolo and Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 2017. Selective targeting of PARP-1 zinc finger recognition domains with Au(III) organometallics. Chemical Communications 54 (6) , pp. 611-614. 10.1039/C7CC08406D |
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Official URL: http://dx.doi.org/10.1039/C7CC08406D
Abstract
The binding of Au(III) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.
Item Type: | Article |
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Date Type: | Published Online |
Status: | Published |
Schools: | Chemistry |
Publisher: | Royal Society of Chemistry |
ISSN: | 1359-7345 |
Date of First Compliant Deposit: | 19 December 2017 |
Date of Acceptance: | 19 December 2017 |
Last Modified: | 06 Nov 2023 20:05 |
URI: | https://orca.cardiff.ac.uk/id/eprint/107680 |
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