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How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission

Lehmann, Martin, Nikolic, Damjan S. and Piguet, Vincent 2011. How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission. Viruses 3 (12) , pp. 1757-1776. 10.3390/v3091757

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Human immunodeficiency virus 1 (HIV-1) infects T cells, macrophages and dendritic cells and can manipulate their cytoskeleton structures at multiple steps during its replication cycle. Based on pharmacological and genetic targeting of cytoskeleton modulators, new imaging approaches and primary cell culture models, important roles for actin and microtubules during entry and cell-to-cell transfer have been established. Virological synapses and actin-containing membrane extensions can mediate HIV-1 transfer from dendritic cells or macrophage cells to T cells and between T cells. We will review the role of the cytoskeleton in HIV-1 entry, cellular trafficking and cell-to-cell transfer between primary cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: HIV-1; actin; microtubules; virological synapse; dendritic cells; cell-to-cell transfer
Publisher: MDPI Publishing
ISSN: 1999-4915
Date of First Compliant Deposit: 19 April 2017
Date of Acceptance: 30 August 2011
Last Modified: 04 Jun 2017 09:48

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