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Implications for room lighting and the duration of acclimation protocols on the dosimetry of inhaled drugs in rats

Paul, Graham, Somers, Graham and Taylor, Glyn 2016. Implications for room lighting and the duration of acclimation protocols on the dosimetry of inhaled drugs in rats. Respiratory Drug Delivery 2 , pp. 327-332.

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Abstract

Inhaled administration of test materials to animals has technical challenges for quantitative dosimetry. Inhaled “doses” reported in non-clinical studies are often calculated using an equation such as that of Alexander et al. [1] to estimate the respired minute volume (eRMV) from body weight data. This approach may overlook physiological effects on lung function associated with a formulation’s properties or habituation of animals to the “dosing” technique. Rats are insensitive to red light [2] and anecdotal data (unpublished) suggested red lighting may induce a calmer state in restrained rats. We hypothesized that the lighting color (red or white) and duration of restraint tube acclimation protocols may influence the breath frequency and minute volume of rats during inhalation exposure, representing a potential source of variability in achieved doses. Head-out plethysmography [3] was used to investigate this hypothesis concurrent with inhaled administration of an anti-inflammatory drug.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Date of First Compliant Deposit: 19 April 2017
Date of Acceptance: 1 April 2016
Last Modified: 01 Jul 2019 00:55
URI: http://orca-mwe.cf.ac.uk/id/eprint/99936

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