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Hey factors at the crossroad of tumorigenesis and clinical therapeutic modulation of Hey for anticancer treatment

Liu, Zihao, Sanders, Andrew J, Liang, Gehao, Song, Erwei, Jiang, Wen G and Gong, Chang 2017. Hey factors at the crossroad of tumorigenesis and clinical therapeutic modulation of Hey for anticancer treatment. Molecular Cancer Therapeutics 16 (5) , pp. 775-786. 10.1158/1535-7163.MCT-16-0576

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Abstract

Hairy and Enhancer-of-split related with YRPW motif (Hey) transcription factors are important regulators of stem cell embryogenesis. Clinical relevance shows that they are also highly expressed in malignant carcinoma. Recent studies have highlighted functions for the Hey factors in tumor metastasis, the maintenance of cancer cell self-renewal, as well as proliferation and the promotion of tumor angiogenesis. Pathways that regulate Hey gene expression, such as Notch and TGFβ signaling, are frequently aberrant in numerous cancers. In addition, Hey factors control downstream targets via recruitment of histone deacetylases (HDAC). Targeting these signaling pathways or HDACs may reverse tumor progression and provide clinical benefit for cancer patients. Thus, some small molecular inhibitors or monoclonal antibodies of each of these signaling pathways have been studied in clinical trials. This review focuses on the involvement of Hey proteins in malignant carcinoma progression and provides valuable therapeutic information for anticancer treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: American Association for Cancer Research
ISSN: 1535-7163
Funders: Cardiff
Date of Acceptance: 29 December 2016
Last Modified: 02 Aug 2017 10:22
URI: http://orca-mwe.cf.ac.uk/id/eprint/99775

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