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Travel- and community-based transmission of multidrug-resistant Shigella sonnei lineage among international Orthodox Jewish communities

Baker, Kate S., Dallman, Timothy J., Behar, Adi, Weill, François-Xavier, Gouali, Malika, Sobel, Jeremy, Fookes, Maria, Valinsky, Lea, Gal-Mor, Ohad, Connor, Thomas Richard, Nissan, Israel, Bertrand, Sophie, Parkhill, Julian, Jenkins, Claire, Cohen, Dani and Thomson, Nicholas R. 2016. Travel- and community-based transmission of multidrug-resistant Shigella sonnei lineage among international Orthodox Jewish communities. Emerging Infectious Diseases 22 (9) , p. 1545. 10.3201/eid2209.151953

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Abstract

Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug–resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: H Social Sciences > HT Communities. Classes. Races
Q Science > QR Microbiology > QR355 Virology
R Medicine > RM Therapeutics. Pharmacology
Publisher: National Center for Infectious Diseases
ISSN: 1080-6040
Last Modified: 10 Jul 2019 09:10
URI: http://orca-mwe.cf.ac.uk/id/eprint/99419

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