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Aspects of carbon monoxide in form of CO-releasing molecules used in cancer treatment: More light on the way

Kourti, Malamati, Jiang, Wen and Cai, Jun 2017. Aspects of carbon monoxide in form of CO-releasing molecules used in cancer treatment: More light on the way. Oxidative Medicine and Cellular Longevity 2017 , 9326454. 10.1155/2017/9326454

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Abstract

Carbon monoxide (CO) has always been recognised as a toxic gas, due to its higher affinity for haemoglobin than oxygen. However, biological studies have revealed an intriguing role for CO as an endogenous signalling molecule, a gasotransmitter. CO is demonstrated to exertmany cellular activities including anti-inflammatory, antiapoptotic, and antiproliferative activities. In animal studies, CO gas administration can prevent tissues from hypoxia or ischemic-reperfusion injury. As a result, there are a plethora of reports dealing with the biological applications of CO and CO-releasing molecules (CORMs) in inflammatory and vascular diseases. CORMs have already been tested as a therapeutic agent in clinical trials. More recently, an increased interest has been drawn to CO’s potential use as an anticancer agent. In this review, we will aim to give an overview of the research focused on the role of COand CORMs in different types of cancer and expand to the recent development of the next generation CORMs for clinical application in cancer treatment.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Hindawi Publishing Corporation
ISSN: 1942-0900
Funders: NRN
Date of First Compliant Deposit: 14 February 2017
Date of Acceptance: 15 January 2017
Last Modified: 26 May 2019 21:40
URI: http://orca-mwe.cf.ac.uk/id/eprint/98315

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