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Probing the molecular recognition of a DNA-RNA hybrid duplex

Wheelhouse, Richard T., Garbett, Nichola C., Buurma, Niklaas Jan and Chaires, Jonathan B. 2010. Probing the molecular recognition of a DNA-RNA hybrid duplex. Angewandte Chemie International Edition 49 (18) , pp. 3207-3210. 10.1002/anie.200907235

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Abstract

Curiouser and curiouser! A biarylpyrimidine ligand shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords: DNA–RNA hybrids; drug discovery; molecular recognition; pyrimidine; RNaseH
Publisher: Wiley
ISSN: 1433-7851
Last Modified: 04 Jun 2017 02:08
URI: http://orca-mwe.cf.ac.uk/id/eprint/9831

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