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The structure of linkers affects the DNA binding properties of tethered dinuclear ruthenium (II) metallo-intercalators

Saeed, Hiwa, Saeed, Ibrahim, Buurma, Niklaas and Thomas, Jim Antony 2017. The structure of linkers affects the DNA binding properties of tethered dinuclear ruthenium (II) metallo-intercalators. Chemistry - A European Journal 23 (23) , 5467 -5477. 10.1002/chem.201605750

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Abstract

With the long-term aim of enhancing the binding properties of dinuclear RuII-based DNA light-switch complexes, a series of eight structurally related mono- and dinuclear systems are reported in which the linker of the bridging ligand has been modulated. These tethered systems have been designed to explore issues of steric demand at the binding site and the thermodynamic cost of entropy loss upon binding. An analysis of detailed spectroscopic and isothermal titration calorimetry (ITC) studies on the new complexes reveal that one of the linkers produces a dinuclear systems that binds to duplex DNA with an affinity (Kb > 107 M-1) that is higher than its corresponding monometallic complex and is the highest affinity for a non-threading bis-intercalating metal complex. These studies confirm that the tether has a major effect on the binding properties of dinuclear complexes containing nintercalating units and establishes key design rules for the construction of dinuclear complexes with enhanced

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: Ruthenium DNA luminescence ITC intercalation
Publisher: WileyBlackwell
ISSN: 0947-6539
Date of First Compliant Deposit: 20 January 2017
Date of Acceptance: 9 January 2017
Last Modified: 03 Jul 2019 02:23
URI: http://orca-mwe.cf.ac.uk/id/eprint/97603

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