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Assessing the potential of mesenchymal stem cells in craniofacial bone repair and regeneration

Waddington, Rachel J., Jones, Quentin and Moseley, Ryan 2016. Assessing the potential of mesenchymal stem cells in craniofacial bone repair and regeneration. In: Waddington, Rachel J. and Sloan, Alastair eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies, Wiley Blackwell, pp. 69-95. (10.1002/9781119282181.ch4)

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Abstract

Bone tissue regeneration is required in clinical procedures such as maxillary sinus floor lift, lateral alveolar augmentation to increase the width of the mandible, and vertical alveolar augmentation to increase the height of the mandible. Bone grafts contain a reservoir of cells involved in the repair process, including mesenchymal stem cells (MSCs), but also a “cocktail” of growth factors embedded within an extracellular matrix (ECM). Rapid bone healing is often the goal for bone healing in craniofacial tissues, and this is ideally achieved by primary bone healing involving predominantly intramembranous ossification where revascularised and bone synthesis facilitate the repair process. When considering the natural healing process, the haematoma, granulation tissue, and the osteoid all support the cells within a 3D ECM structure. These natural matrix scaffolds provide a spatial arrangement for facilitating cell focal contacts and the delivery of growth factors to cell surface receptors.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > RK Dentistry
Publisher: Wiley Blackwell
ISBN: 978-1118741108
Last Modified: 31 Mar 2020 12:52
URI: http://orca-mwe.cf.ac.uk/id/eprint/97137

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