Knighton, Richard Charles, Hallett, Andrew Jon, Kariuki, Benson and Pope, Simon J. A. 2010. A one-step synthesis towards new ligands based on aryl-functionalised thiazolo[5,4-d]thiazole chromophores. Tetrahedron Letters 51 (41) , pp. 5419-5422. 10.1016/j.tetlet.2010.07.172 |
Abstract
A general synthesis of disubstituted thiazolo[5,4-d]thiazoles was achieved by condensing two equivalents of an aryl aldehyde with dithiooxamide in nitrobenzene at 130 °C for 24 h. The method is tolerant to a range of aromatic aldehydes including derivatives of pyridine, quinoline, mono- and dihydroxybenzene. An X-ray crystal structure of 2,5-bis(2-hydroxy-3,5-di-tert-butylphenyl)thiazolo[5,4-d]thiazole was obtained confirming the proposed formulation, together with supporting spectroscopic data that suggests that for the 2-hydroxyphenyl derivatives intramolecular hydrogen bonding exists in both solution and solid states.
Item Type: | Article |
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Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | Elsevier |
ISSN: | 0040-4039 |
Last Modified: | 03 Apr 2018 20:35 |
URI: | http://orca-mwe.cf.ac.uk/id/eprint/9701 |
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