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Ageing of the B-cell repertoire

Martin, Victoria, (Bryan) Wu, Yu-Chang, Kipling, David and Dunn-Walters, Deborah 2015. Ageing of the B-cell repertoire. Philosophical Transactions of the Royal Society B: Biological Sciences 370 (1676) , 20140237. 10.1098/rstb.2014.0237

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Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challenge, and that this loss of B-cell diversity correlates with poor health. Studies on response to vaccination, using both spectratyping and high-throughput sequencing of the repertoire, indicate that older responses to challenge are lacking in magnitude and/or delayed significantly. Also that some of the biologically significant differences may be in different classes of antibody. We have also previously shown that normal young B-cell repertoires can vary between different phenotypic subsets of B cells. In this paper, we present an analysis of immunoglobulin repertoire in different subclasses of antibody in five different populations of B cell, and show how the repertoire in these different groups changes with age. Although some age-related repertoire differences occur in naive cells, before exogenous antigen exposure, we see indications that there is a general dysregulation of the selective forces that shape memory B-cell populations in older people.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: B-cell memory; ageing; immunoglobulin repertoire; subclass of antibody
Publisher: The Royal Society
ISSN: 0962-8436
Date of Acceptance: 6 February 2015
Last Modified: 14 Jun 2019 09:35

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