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Structural biology in antiviral drug discovery

Bassetto, Marcella, Massarotti, Alberto, Coluccia, Antonio and Brancale, Andrea 2016. Structural biology in antiviral drug discovery. Current Opinion in Pharmacology 30 , pp. 116-130. 10.1016/j.coph.2016.08.014

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Abstract

Structural biology has emerged during the last thirty years as a powerful tool for rational drug discovery. Crystal structures of biological targets alone and in complex with ligands and inhibitors provide essential insights into the mechanisms of actions of enzymes, their conformational changes upon ligand binding, the architectures and interactions of binding pockets. Structure-based methods such as crystallographic fragment screening represent nowadays invaluable instruments for the identification of new biologically active compounds. In this context, three-dimensional protein structures have played essential roles for the understanding of the activity and for the design of novel antiviral agents against several different viruses. In this review, the evolution in the resolution of viral structures is analysed, along with the role of crystal structures in the discovery and optimisation of new antivirals.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: Elsevier
ISSN: 1471-4892
Date of First Compliant Deposit: 19 September 2016
Date of Acceptance: 29 August 2016
Last Modified: 12 Jan 2018 00:15
URI: http://orca-mwe.cf.ac.uk/id/eprint/94639

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