Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Bicatalytic multistep reactions en route to the one-pot total synthesis of complex molecules: easy access to chromene and 1,2-dihydroquinoline derivatives from simple substrates

Giorgi, Pascal D., Miedziak, Peter John, Edwards, Jennifer Kelly, Hutchings, Graham John and Antoniotti, Sylvain 2017. Bicatalytic multistep reactions en route to the one-pot total synthesis of complex molecules: easy access to chromene and 1,2-dihydroquinoline derivatives from simple substrates. ChemCatChem 9 (1) , pp. 70-75. 10.1002/cctc.201600925

[img]
Preview
PDF - Accepted Post-Print Version
Download (1MB) | Preview
[img]
Preview
PDF - Supplemental Material
Download (1MB) | Preview

Abstract

By combining nanocatalysis and base-catalysis, a novel one-pot multistep process was found for the synthesis of substituted heterocycles of biological relevance from simple substrates. It is based on an initial Au/O2 oxidation of allylic alcohols followed by a base-catalysed tandem hetero-Michael/aldolisation/crotonisation with ortho-hydroxy or ortho-amino benzaldehydes. The flexibility of the reaction even allowed the benzaldehyde partner to be prepared in situ in an example of one-pot/5-steps process.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff Catalysis Institute (CCI)
Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Wiley
ISSN: 1867-3880
Funders: EPSRC
Date of First Compliant Deposit: 8 September 2016
Date of Acceptance: 7 September 2016
Last Modified: 03 Jul 2019 09:31
URI: http://orca-mwe.cf.ac.uk/id/eprint/94373

Citation Data

Cited 3 times in Google Scholar. View in Google Scholar

Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics