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Association of inflammation with specific symptoms of depression in a general population of older people: The English Longitudinal Study of Ageing

White, Jamie, Kivimäki, Mika, Jokela, Markus and Batty, G. David 2017. Association of inflammation with specific symptoms of depression in a general population of older people: The English Longitudinal Study of Ageing. Brain, Behavior, and Immunity 61 , pp. 27-30. 10.1016/j.bbi.2016.08.012

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Abstract

Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in people with depression. Few studies have examined whether the association between inflammation and depression is symptom specific, and differs according to antidepressant treatment. Using data from the English Longitudinal Study of Ageing (N = 5 909), cross-sectional analyses revealed a significant dose-response association between C-reactive protein and the symptoms of fatigue (P < 0.001), restless sleep (P = 0.03), low energy (P = 0.02) and feeling depressed (P = 0.04), but not other symptoms. These associations were absent in users of anti-depressant medication. Our findings suggest the C-reactive protein-depression association is symptom-specific and modified by antidepressant treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Development and Evaluation of Complex Interventions for Public Health Improvement (DECIPHer)
Medicine
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Uncontrolled Keywords: C-reactive protein; Depression; Antidepressants
Publisher: Elsevier
ISSN: 0889-1591
Date of First Compliant Deposit: 31 August 2016
Date of Acceptance: 21 August 2016
Last Modified: 17 Jun 2017 11:40
URI: http://orca-mwe.cf.ac.uk/id/eprint/94083

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