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Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer

Fiore, E., Giustarini, E., Mammoli, C., Fragomeni, F., Campani, D., Muller, Ilaria, Pinchera, A. and Giani, C. 2007. Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer. Journal of Endocrinological Investigation 30 (9) , pp. 734-738. 10.1007/BF03350810

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Abstract

A high incidence of anti-thyroid antibodies (TAb) has been found in patients with breast cancer (BC). The aim of this study was to evaluate the prognostic value of TAb in a group of 47 women submitted to mastectomy for high malignancy degree BC. All patients were evaluated for thyroid disorders after breast surgery and before any anti-tumoral adjuvant therapy. Five yr after BC diagnosis 31/47 (65.9%) patients were alive (survivors group: SG) and 16/47 (34.1%) were dead (deaths group: DG). The overall prevalence of TAb was 15/47 (31.9%): 14/31 (45.1%) in SG and 1/16 (6.2%) in DG (p=0.008). Five-yr mortality was 15/32 (46.9%) in TAb- and 1/15 (6.7%) in TAb+ patients (p=0.01). Eight out of 47 (17.0%) patients had Hashimoto’s thyroiditis and 7 of them (87.5%) were in SG. Estrogen receptor (ER) was measured in 43/47 (91.5%) BC specimens. ER was detected in 19/30 (63.0%) patients in SG and 3/13 (23.1%) in DG (p=0.01). Five-yr mortality was 10/21 (47.6%) in ER- and 3/22 (13.6%) in ER+ patients (p=0.008). Absence of ER expression [odds ratio (OR) 6.54; p=0.006] and absence of TAb (OR 9.37; p=0.03) were related to a higher mortality rate. TAb were detected in 8/21 (38.1%) ER- and in 7/22 (31.8%) ER+ patients; no relation was found between ER expression and TAb positivity (p=ns). Patients with ER+ and TAb+ have a better prognosis and the absence of a significant relationship between these two parameters suggests an independent prognostic role in high malignancy degree BC women.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Editrice Kurtis
ISSN: 0391-4097
Last Modified: 04 Jun 2017 09:21
URI: http://orca-mwe.cf.ac.uk/id/eprint/93820

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