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Transglutaminase 2 in cartilage homeostasis: novel links with inflammatory osteoarthritis

Adamczyk, Magdalena 2017. Transglutaminase 2 in cartilage homeostasis: novel links with inflammatory osteoarthritis. Amino Acids 49 (3) , pp. 625-633. 10.1007/s00726-016-2305-1

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Abstract

Transglutaminase 2 (TG2) is highly expressed during chondrocyte maturation and contributes to the formation of a mineralised scaffold by introducing crosslinks between extracellular matrix (ECM) proteins. In healthy cartilage, TG2 stabilises integrity of ECM and likely influences cartilage stiffness and mechanistic properties. At the same time, the abnormal accumulation of TG2 in the ECM promotes chondrocyte hypertrophy and cartilage calcification, which might be an important aspect of osteoarthritis (OA) initiation. Although excessive joint loading and injuries are one of the main causes leading to OA development, it is now being recognised that the presence of inflammatory mediators accelerates OA progression. Inflammatory signalling is known to stimulate the extracellular TG2 activity in cartilage and promote TG2-catalysed crosslinking of molecules that promote chondrocyte osteoarthritic differentiation. It is, however, unclear whether TG2 activity aims to resolve or aggravate damages within the arthritic joint. Better understanding of the complex signalling pathways linking inflammation with TG2 activities is needed to identify the role of TG2 in OA and to define possible avenues for therapeutic interventions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Transglutaminase Osteoarthritis Cartilage Inflammation Chondrocyte hypertrophy
Publisher: Springer Verlag
ISSN: 0939-4451
Funders: Arthritis Research UK
Date of First Compliant Deposit: 8 August 2016
Date of Acceptance: 28 July 2016
Last Modified: 04 Jun 2017 09:20
URI: http://orca-mwe.cf.ac.uk/id/eprint/93409

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